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IPR036598 is a GOLD domain superfamily.
<p>The GOLD (for Golgi dynamics) domain is a protein module found in several eukaryotic Golgi and lipid-traffic proteins. It is typically between 90 and 150 amino acids long. Most of the size difference observed in the GOLD-domain superfamily is traceable to a single large low-complexity insert that is seen in some versions of the domain. With the exception of the p24 proteins, which have a simple architecture with the GOLD domain as their only globular domain, all other GOLD-domain proteins contain additional conserved globular domains. In these proteins, the GOLD domain co-occurs with lipid-, sterol-or fatty acid-binding domains such as PH, CRAL-TRIO, FYVE oxysterol binding-and acyl CoA-binding domains, suggesting that these proteins may interact with membranes. The GOLD domain can also be found associated with a RUN domain, which may have a role in the interaction of various proteins with cytoskeletal filaments. The GOLD domain is predicted to mediate diverse protein-protein interactions [[cite:PUB00011844]]. A secondary structure prediction for the GOLD domain reveals that it is likely to adopt a compact all-β-fold structure with six to seven strands. Most of the sequence conservation is centred on the hydrophobic cores that support these predicted strands. The predicted secondary-structure elements and the size of the conserved core of the domain suggests that it may form a β-sandwich fold with the strands arranged in two β-sheets stacked on each other [[cite:PUB00011844]].</p> <p>Some proteins known to contain a GOLD domain are listed below:</p> <ul> <li>Eukaryotic proteins of the p24 family.</li> <li>Animal Sec14-like proteins. They are involved in secretion.</li> <li>Human Golgi resident protein GCP60. It interacts with the Golgi integral membrane protein Giantin.</li> <li>Yeast oxysterol-binding protein homologue 3 (OSH3).</li> </ul>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phosphatidylinositol transfer protein; TAIR: AT4G09160.1 SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein; Swiss-Prot: sp|Q9M0R2|PATL5_ARATH Patellin-5; TrEMBL-Plants: tr|A0A072V1D5|A0A072V1D5_MEDTR Patellin-3 protein; Found in the gene: LotjaGi1g1v0328300 | 21 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT3G51670.1 SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein; Swiss-Prot: sp|Q9SCU1|PATL6_ARATH Patellin-6; TrEMBL-Plants: tr|A0A151RRX9|A0A151RRX9_CAJCA Patellin-6; Found in the gene: LotjaGi1g1v0447900 | 20 | ||
| – | Transmembrane emp24 domain-containing protein; TAIR: AT3G22845.1 emp24/gp25L/p24 family/GOLD family protein; Swiss-Prot: sp|Q9LIL4|P24B3_ARATH Transmembrane emp24 domain-containing protein p24beta3; TrEMBL-Plants: tr|A0A072U3W0|A0A072U3W0_MEDTR Emp24/gp25L/p24 family/GOLD protein; Found in the gene: LotjaGi1g1v0715500 | 17 | ||
| – | Retinal-binding; TAIR: AT5G01010.1 retinal-binding protein; Swiss-Prot: sp|P49193|RALB_TODPA Retinal-binding protein; TrEMBL-Plants: tr|I1MQR1|I1MQR1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0053600 | 10 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT3G51670.1 SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein; Swiss-Prot: sp|Q9SCU1|PATL6_ARATH Patellin-6; TrEMBL-Plants: tr|A0A151RRX9|A0A151RRX9_CAJCA Patellin-6; Found in the gene: LotjaGi3g1v0201200 | 20 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT3G51670.1 SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein; Swiss-Prot: sp|Q9SCU1|PATL6_ARATH Patellin-6; TrEMBL-Plants: tr|A0A151RRX9|A0A151RRX9_CAJCA Patellin-6; Found in the gene: LotjaGi3g1v0201200 | 19 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT4G09160.1 SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein; Swiss-Prot: sp|Q9M0R2|PATL5_ARATH Patellin-5; TrEMBL-Plants: tr|I1KWA0|I1KWA0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0556200 | 22 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT1G72160.1 Sec14p-like phosphatidylinositol transfer family protein; Swiss-Prot: sp|Q56Z59|PATL3_ARATH Patellin-3; TrEMBL-Plants: tr|A0A1J7HZ98|A0A1J7HZ98_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0416000 | 22 | ||
| – | Phosphatidylinositol transfer protein; TAIR: AT1G72160.1 Sec14p-like phosphatidylinositol transfer family protein; Swiss-Prot: sp|Q56Z59|PATL3_ARATH Patellin-3; TrEMBL-Plants: tr|A0A151S2I8|A0A151S2I8_CAJCA Patellin-3; Found in the gene: LotjaGi5g1v0091300 | 21 | ||
| – | Transmembrane emp24 domain-containing protein; TAIR: AT3G22845.1 emp24/gp25L/p24 family/GOLD family protein; Swiss-Prot: sp|Q9LIL4|P24B3_ARATH Transmembrane emp24 domain-containing protein p24beta3; TrEMBL-Plants: tr|I3S9R4|I3S9R4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0309900 | 19 | ||
| – | Transmembrane emp24 domain-containing protein; TAIR: AT3G22845.1 emp24/gp25L/p24 family/GOLD family protein; Swiss-Prot: sp|Q9LIL4|P24B3_ARATH Transmembrane emp24 domain-containing protein p24beta3; TrEMBL-Plants: tr|I3S9R4|I3S9R4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0309900 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 9.09 |