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IPR039515 is a NOT4, modified RING finger, HC subclass (C4C4-type).
<p>NOT4, also known as CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, or potential transcriptional repressor NOT4, is a component of the multifunctional CCR4-NOT complex, a global regulator of RNA polymerase II transcription. It associates with polysomes and contributes to the negative regulation of protein synthesis [[cite:PUB00024425], [cite:PUB00044101], [cite:PUB00089742], [cite:PUB00089743], [cite:PUB00089744], [cite:PUB00089745], [cite:PUB00089747], [cite:PUB00089748]]. NOT4 functions as an E3 ubiquitin-protein ligase that interacts with a specific E2, Ubc4/5 in yeast, and the orthologue UbcH5B in humans, and ubiquitylates a wide range of substrates, including ribosome-associated factors [[cite:PUB00089746]]. Thus, it plays a role in cotranslational quality control (QC) through ribosome-associated ubiquitination and degradation of aberrant peptides. NOT4 contains a C4C4-type RING finger motif, whose overall folding is similar to that of the C3HC4-type RING-HC finger, a central RNA recognition motif (RRM), and a C-terminal domain predicted to be unstructured [[cite:PUB00031865]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | General negative regulator of transcription subunit 4; TAIR: AT3G48070.1 RING/U-box superfamily protein; Swiss-Prot: sp|P34909|NOT4_YEAST General negative regulator of transcription subunit 4; TrEMBL-Plants: tr|I3S4I8|I3S4I8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0252700 | 12 | ||
| – | General negative regulator of transcription subunit 4; TAIR: AT3G48070.1 RING/U-box superfamily protein; Swiss-Prot: sp|P34909|NOT4_YEAST General negative regulator of transcription subunit 4; TrEMBL-Plants: tr|I3S4I8|I3S4I8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0252700 | 12 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A151TN31|A0A151TN31_CAJCA CCR4-NOT transcription complex subunit 4; Found in the gene: LotjaGi2g1v0365000 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT5G60170.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A0R0FWC0|A0A0R0FWC0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0270600 | 25 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7M9K7|K7M9K7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0270600 | 24 | ||
| – | RING/U-box superfamily protein; TAIR: AT5G62910.1 RING/U-box superfamily protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A151R8X5|A0A151R8X5_CAJCA CCR4-NOT transcription complex subunit 4; Found in the gene: LotjaGi4g1v0241400 | 12 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |