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IPR039780 is a CCR4-NOT transcription complex subunit 4.
<p>NOT4, also known as CNOT4 or MOT2, is a component of the CCR4-NOT complex, a global negative regulator of RNA polymerase II transcription [[cite:PUB00044101]]. It associates with polysomes and contributes to the negative regulation of protein synthesis [[cite:PUB00044101], [cite:PUB00024425], [cite:PUB00089742], [cite:PUB00089743], [cite:PUB00089744], [cite:PUB00089745], [cite:PUB00089747], [cite:PUB00089748]]. NOT4 functions as an E3 ubiquitin-protein ligase that interacts with a specific E2, Ubc4/5 in yeast, and the orthologue UbcH5B in humans, and ubiquitinates a wide range of substrates, including ribosome-associated factors [[cite:PUB00089746]]. Thus, it plays a role in cotranslational quality control (QC) through ribosome-associated ubiquitination and degradation of aberrant peptides. NOT4 contains a C4C4-type RING finger motif, whose overall folding is similar to that of the C3HC4-type RING-HC finger, a central RNA recognition motif (RRM), and a C-terminal domain predicted to be unstructured [[cite:PUB00031865]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. | ||
| Cellular component | CCR4-NOT complex | The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | General negative regulator of transcription subunit 4; TAIR: AT3G48070.1 RING/U-box superfamily protein; Swiss-Prot: sp|P34909|NOT4_YEAST General negative regulator of transcription subunit 4; TrEMBL-Plants: tr|I3S4I8|I3S4I8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0252700 | 12 | ||
| – | General negative regulator of transcription subunit 4; TAIR: AT3G48070.1 RING/U-box superfamily protein; Swiss-Prot: sp|P34909|NOT4_YEAST General negative regulator of transcription subunit 4; TrEMBL-Plants: tr|I3S4I8|I3S4I8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0252700 | 12 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A151TN31|A0A151TN31_CAJCA CCR4-NOT transcription complex subunit 4; Found in the gene: LotjaGi2g1v0365000 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT5G60170.2 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A0R0FWC0|A0A0R0FWC0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0270600 | 25 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7M9K7|K7M9K7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0270600 | 24 | ||
| – | RING/U-box superfamily protein; TAIR: AT5G62910.1 RING/U-box superfamily protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|A0A151R8X5|A0A151R8X5_CAJCA CCR4-NOT transcription complex subunit 4; Found in the gene: LotjaGi4g1v0241400 | 12 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 | ||
| – | CCR4-NOT transcription complex subunit 4; TAIR: AT3G45630.1 RNA binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|O95628|CNOT4_HUMAN CCR4-NOT transcription complex subunit 4; TrEMBL-Plants: tr|K7LHH2|K7LHH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0073600 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |