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IPR040125

Source: InterPro

Description

IPR040125 is a Squalene monooxygenase.

<p>Squalene is a precursor for the synthesis of sterols in eukaryotes. Squalene monooxygenase, also called squalene epoxidase, catalyzes the first oxygenation step in sterol biosynthesis and is a rate-limiting enzyme in this pathway. In Saccharomyces cerevisiae, squalene is the first precursor dedicated to ergosterol biosynthesis [[cite:PUB00090557]]. Squalene monooxygenase is regulated both transcriptionally and post-translationally [[cite:PUB00090555], [cite:PUB00090559]]. It is involved in tumorigenesis [[cite:PUB00090556], [cite:PUB00090558]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004506
Molecular function Squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
Subterm of
GO:0016126
Biological process Sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Subterm of

Associated Lotus transcripts 19

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0363700.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1K897|I1K897_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0363700
Domains
16
LotjaGi1g1v0363700.2
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A151TTQ0|A0A151TTQ0_CAJCA Squalene monooxygenase; Found in the gene: LotjaGi1g1v0363700
Domains
12
LotjaGi4g1v0043300.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300
Domains
15
LotjaGi4g1v0043300.2
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300
Domains
15
LotjaGi4g1v0043300.3
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300
Domains
15
LotjaGi4g1v0043300.4
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300
Domains
15
LotjaGi4g1v0043300.5
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300
Domains
12
LotjaGi4g1v0043300.6
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2SMP9|A0A0B2SMP9_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi4g1v0043300
Domains
12
LotjaGi4g1v0043300.7
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2SMP9|A0A0B2SMP9_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi4g1v0043300
Domains
12
LotjaGi4g1v0043300.8
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi4g1v0043300
Domains
11
LotjaGi4g1v0043600.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043600
Domains
15
LotjaGi5g1v0037500.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2RV99|A0A0B2RV99_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi5g1v0037500
Domains
16
LotjaGi5g1v0037500.2
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2QBL8|A0A0B2QBL8_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi5g1v0037500
Domains
12
LotjaGi6g1v0181200.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|K7MRG5|K7MRG5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0181200
Domains
17
LotjaGi6g1v0345600.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345600
Domains
16
LotjaGi6g1v0345600.2
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345600
Domains
15
LotjaGi6g1v0345600.3
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1M2I5|I1M2I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0345600
Domains
13
LotjaGi6g1v0345600.4
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1M2I5|I1M2I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0345600
Domains
13
LotjaGi6g1v0345900.1
– Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345900
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 5.26