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IPR013698 is a Squalene epoxidase.
<p>This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae (Baker's yeast) where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [[cite:PUB00020824]]. Putative transmembrane regions are found to the protein's C terminus.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Squalene monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: squalene monooxygenase-like [Cicer arietinum] gi|502142293|ref|XP_004504886.1| | 7 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356569981|ref|XP_003553171.1| | 17 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356521261|ref|XP_003529275.1| | 10 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356521261|ref|XP_003529275.1| | 13 | ||
| – | PREDICTED: squalene monooxygenase-like isoform X1 [Cicer arietinum] gi|502132708|ref|XP_004501491.1| | 14 | ||
| – | PREDICTED: squalene monooxygenase-like isoform X5 [Cicer arietinum] gi|502132716|ref|XP_004501495.1| | 10 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356521261|ref|XP_003529275.1| | 13 | ||
| – | PREDICTED: squalene monooxygenase-like [Cicer arietinum] gi|502142293|ref|XP_004504886.1| | 10 | ||
| – | PREDICTED: squalene monooxygenase-like [Cicer arietinum] gi|502142293|ref|XP_004504886.1| | 7 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356577688|ref|XP_003556956.1| | 14 | ||
| – | Squalene monooxygenase [Theobroma cacao] gi|508705377|gb|EOX97273.1| | 6 | ||
| – | PREDICTED: squalene monooxygenase-like [Glycine max] gi|356521261|ref|XP_003529275.1| | 14 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1K897|I1K897_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0363700 | 16 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A151TTQ0|A0A151TTQ0_CAJCA Squalene monooxygenase; Found in the gene: LotjaGi1g1v0363700 | 12 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043300 | 12 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2SMP9|A0A0B2SMP9_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi4g1v0043300 | 12 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2SMP9|A0A0B2SMP9_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi4g1v0043300 | 12 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi4g1v0043300 | 11 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1KL88|I1KL88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0043600 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2RV99|A0A0B2RV99_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi5g1v0037500 | 16 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A0B2QBL8|A0A0B2QBL8_GLYSO Squalene monooxygenase; Found in the gene: LotjaGi5g1v0037500 | 12 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|K7MRG5|K7MRG5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0181200 | 17 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345600 | 16 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345600 | 15 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1M2I5|I1M2I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0345600 | 13 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|I1M2I5|I1M2I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0345600 | 13 | ||
| – | Squalene monooxygenase; TAIR: AT1G58440.1 FAD/NAD(P)-binding oxidoreductase family protein; Swiss-Prot: sp|O48651|ERG1_PANGI Squalene monooxygenase; TrEMBL-Plants: tr|A0A075DZG2|A0A075DZG2_ASTME Squalene epoxidase; Found in the gene: LotjaGi6g1v0345900 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 3.23 |