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IPR043198 is a Cyclin/Cyclin-like subunit Ssn8.
<p>Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [[cite:PUB00014103]].</p> <p>This entry represents several Cyclin families (C, L, Q, T1, T2, and H/Ccl1) and yeast RNA polymerase II holoenzyme cyclin-like subunit (also known as Ssn8/Srb11).</p> <ul><li>Cyclin C can regulate both cell cycle progression and gene transcription. The Cdk8-cyclin C complex is a component of the RNA polymerase II holoenzyme [[cite:PUB00055077]].</li> <li>Cyclin L is a transcriptional regulator involved in the regulation of RNA polymerase II transcription and participating in regulating the pre-mRNA splicing process [[cite:PUB00034807], [cite:PUB00068054]].</li> <li>Cyclin Q (also known as Cyclin M) consists of cyclin-related protein FAM58A [[cite:PUB00087326]].</li> <li>Cyclin-T2 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex [[cite:PUB00016032]].</li> <li>Cyclin-H from vertebrates, mcs2 from fission yeast and Ccl1 from budding yeasts are cyclins that play a role in cell cycle [[cite:PUB00069500]].</li> <li>Cyclin-T associates with CDK9 which are subunits of the positive-transcription elongation factor (P-TEFb) [[cite:PUB00069674]].</li></ul> <p>Ssn8/Srb11 is a component of the SRB8-11 complex (consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11), which is a regulatory module of the mediator complex that is involved in regulation of basal and activated RNA polymerase II-dependent transcription [[cite:PUB00062858], [cite:PUB00062859]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. | ||
| Molecular function | Cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. | ||
| Cellular component | Host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cyclin family protein; TAIR: AT5G48630.1 Cyclin family protein; Swiss-Prot: sp|Q9FJK7|CCC12_ARATH Cyclin-C1-2; TrEMBL-Plants: tr|I1N1Z8|I1N1Z8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0591800 | 13 | ||
| – | Cyclin family protein; TAIR: AT5G45190.1 Cyclin family protein; Swiss-Prot: sp|Q9FKE6|CCT15_ARATH Cyclin-T1-5; TrEMBL-Plants: tr|V7BT73|V7BT73_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0036100 | 14 | ||
| – | Cyclin family protein; TAIR: AT5G45190.1 Cyclin family protein; Swiss-Prot: sp|Q9FKE6|CCT15_ARATH Cyclin-T1-5; TrEMBL-Plants: tr|V7BT73|V7BT73_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0036100 | 14 | ||
| – | Cyclin family protein; TAIR: AT5G45190.1 Cyclin family protein; Swiss-Prot: sp|Q2RAC5|CCT13_ORYSJ Cyclin-T1-3; TrEMBL-Plants: tr|A0A1J7FWL8|A0A1J7FWL8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0036200 | 16 | ||
| – | Cyclin-L1-1; TAIR: AT2G26430.1 arginine-rich cyclin 1; Swiss-Prot: sp|Q8RWV3|CCL11_ARATH Cyclin-L1-1; TrEMBL-Plants: tr|A0A151U588|A0A151U588_CAJCA Cyclin-L1-1; Found in the gene: LotjaGi3g1v0053000 | 13 | ||
| – | Cyclin-like protein; TAIR: AT2G26430.1 arginine-rich cyclin 1; Swiss-Prot: sp|Q8RWV3|CCL11_ARATH Cyclin-L1-1; TrEMBL-Plants: tr|A0A151U588|A0A151U588_CAJCA Cyclin-L1-1; Found in the gene: LotjaGi3g1v0053000 | 12 | ||
| – | Cyclin family protein; TAIR: AT5G45190.1 Cyclin family protein; Swiss-Prot: sp|Q9FKE6|CCT15_ARATH Cyclin-T1-5; TrEMBL-Plants: tr|V7C928|V7C928_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0086100 | 10 | ||
| – | Cyclin family protein; TAIR: AT5G45190.1 Cyclin family protein; Swiss-Prot: sp|Q9FKE6|CCT15_ARATH Cyclin-T1-5; TrEMBL-Plants: tr|V7C928|V7C928_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0086100 | 13 | ||
| – | Cyclin-like protein; TAIR: AT5G27620.1 cyclin H;1; Swiss-Prot: sp|Q8W5S1|CCH11_ARATH Cyclin-H1-1; TrEMBL-Plants: tr|I1KBX6|I1KBX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0221600 | 14 | ||
| – | Cyclin-like protein; TAIR: AT5G27620.1 cyclin H;1; Swiss-Prot: sp|Q8W5S1|CCH11_ARATH Cyclin-H1-1; TrEMBL-Plants: tr|I1KBX6|I1KBX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0221600 | 14 | ||
| – | Cyclin-H1-1; TAIR: AT5G27620.1 cyclin H;1; Swiss-Prot: sp|Q8W5S1|CCH11_ARATH Cyclin-H1-1; TrEMBL-Plants: tr|I3SRL2|I3SRL2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0221600 | 9 | ||
| – | Cyclin-H1-1; TAIR: AT5G27620.1 cyclin H;1; Swiss-Prot: sp|Q8W5S1|CCH11_ARATH Cyclin-H1-1; TrEMBL-Plants: tr|I3SRL2|I3SRL2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0221600 | 9 | ||
| – | Cyclin family protein; TAIR: AT4G19600.1 Cyclin family protein; Swiss-Prot: sp|Q2QQS5|CCT14_ORYSJ Cyclin-T1-4; TrEMBL-Plants: tr|K7N3F6|K7N3F6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315900 | 12 | ||
| – | Cyclin family protein; TAIR: AT4G19600.1 Cyclin family protein; Swiss-Prot: sp|Q2QQS5|CCT14_ORYSJ Cyclin-T1-4; TrEMBL-Plants: tr|K7N3F6|K7N3F6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315900 | 12 | ||
| – | Cyclin family protein; TAIR: AT4G19600.1 Cyclin family protein; Swiss-Prot: sp|Q2QQS5|CCT14_ORYSJ Cyclin-T1-4; TrEMBL-Plants: tr|K7N3F7|K7N3F7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315900 | 12 | ||
| – | Cyclin family protein; TAIR: AT4G19600.1 Cyclin family protein; Swiss-Prot: sp|Q2QQS5|CCT14_ORYSJ Cyclin-T1-4; TrEMBL-Plants: tr|K7N3F7|K7N3F7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315900 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.25 |