Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
Field | Value |
---|---|
Namespace | Cellular component |
Short description | Elongator holoenzyme complex |
Full defintion | A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. |
Subterm of |
The relationship of GO:0033588 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0033588, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | vw |
PMID | A coordinated codon-dependent regulation of translation by Elongator. Cell Cycle. 2012 Dec 15; 11 (24): 4524–9.PMID: 23165209 More than a decade ago, the purification of the form of the RNA polymerase II (PolII) engaged in elongation led to the discovery of an associated, multi-subunit (Elp1-6) complex named "Elongator" by the Svejstrup lab. Although further evidence supported the original notion that Elongator is involved in transcription, Elongator lacked some of the expected features for a regulator of the elongating PolII. The discovery by the Byström lab, based on genetic dissection, that Elongator is pivotal for tRNA modifications, and that all the reported phenotypes of Elongator mutants are suppressed by the overexpression of two tRNAs added to the confusion. The increasing range of both potential substrates and biological processes regulated by Elongator in higher eukaryotes indicates that the major challenge of the field is to determine the biologically relevant function of Elongator. Our recent proteome-wide study in fission yeast supports a coordinated codon-dependent regulation of translation by Elongator. Here we provide additional analyses extending this hypothesis to budding yeast and worm. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: elongator complex protein 4-like [Glycine max] gi|356504547|ref|XP_003521057.1| | 2 | ||
– | PREDICTED: elongator complex protein 6-like [Cicer arietinum] gi|502103167|ref|XP_004492218.1| | 2 | ||
– | PREDICTED: elongator complex protein 6-like [Cicer arietinum] gi|502103167|ref|XP_004492218.1| | 2 | ||
– | Elongator complex protein [Medicago truncatula] gi|358344187|ref|XP_003636173.1| | 2 | ||
– | PREDICTED: dermal papilla-derived protein 6 homolog [Glycine max] gi|356500866|ref|XP_003519251.1| | 2 | ||
– | PREDICTED: elongator complex protein 4-like isoform X1 [Cicer arietinum] gi|502173415|ref|XP_004515324.1| | 2 | ||
– | PREDICTED: elongator complex protein 1-like isoform X2 [Cicer arietinum] gi|502121382|ref|XP_004497296.1| | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VSS4|A0A072VSS4_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi1g1v0075200 | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi1g1v0075200 | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VSS4|A0A072VSS4_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi1g1v0075200 | 2 | ||
– | AT2G18410-like protein; TAIR: AT2G18410.1 elongator complex protein; Swiss-Prot: sp|F4IQJ2|ELP5_ARATH Elongator complex protein 5; TrEMBL-Plants: tr|K7KA66|K7KA66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0120300 | 2 | ||
– | Elongator complex protein 6; TAIR: AT4G10090.1 elongator protein 6; Swiss-Prot: sp|Q8L9Y2|ELP6_ARATH Elongator complex protein 6; TrEMBL-Plants: tr|C6TH84|C6TH84_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0596800 | 2 | ||
– | Elongator complex protein 4; TAIR: AT3G11220.1 Paxneb protein-like protein; Swiss-Prot: sp|Q9C778|ELP4_ARATH Elongator complex protein 4; TrEMBL-Plants: tr|A0A072TM62|A0A072TM62_MEDTR Elongator complex protein; Found in the gene: LotjaGi2g1v0084000_LC | 2 | ||
– | Elongator complex protein 4; TAIR: AT3G11220.1 Paxneb protein-like protein; Swiss-Prot: sp|Q9C778|ELP4_ARATH Elongator complex protein 4; TrEMBL-Plants: tr|A0A072TKF7|A0A072TKF7_MEDTR Elongator complex protein; Found in the gene: LotjaGi3g1v0068800 | 2 | ||
– | Elongator complex protein 4; TAIR: AT3G11220.1 Paxneb protein-like protein; Swiss-Prot: sp|Q9C778|ELP4_ARATH Elongator complex protein 4; TrEMBL-Plants: tr|A0A072TKF7|A0A072TKF7_MEDTR Elongator complex protein; Found in the gene: LotjaGi3g1v0068800 | 2 | ||
– | Elongator complex protein 4; TAIR: AT3G11220.1 Paxneb protein-like protein; Swiss-Prot: sp|Q9C778|ELP4_ARATH Elongator complex protein 4; TrEMBL-Plants: tr|A0A072TKF7|A0A072TKF7_MEDTR Elongator complex protein; Found in the gene: LotjaGi3g1v0068800 | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VSS4|A0A072VSS4_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|V7BCU8|V7BCU8_PHAVU Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VSS4|A0A072VSS4_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|A0A072VRS1|A0A072VRS1_MEDTR Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 1; TAIR: AT5G13680.1 IKI3 family protein; Swiss-Prot: sp|Q9FNA4|ELP1_ARATH Elongator complex protein 1; TrEMBL-Plants: tr|V7BCU8|V7BCU8_PHAVU Elongator complex protein 1; Found in the gene: LotjaGi5g1v0355700_LC | 2 | ||
– | Elongator complex protein 4; TAIR: AT3G11220.1 Paxneb protein-like protein; Swiss-Prot: sp|Q9C778|ELP4_ARATH Elongator complex protein 4; TrEMBL-Plants: tr|I1LXN7|I1LXN7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0074700 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Elongator holoenzyme complex | 1 | 3.03 |