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IPR000133 is a ER lumen protein retaining receptor.
<p>Proteins resident in the lumen of the endoplasmic reticulum (ER) contain a C-terminal tetrapeptide, commonly known as Lys-Asp-Glu-Leu (KDEL) in mammals and His-Asp-Glu-Leu (HDEL) in yeast (Saccharomyces cerevisiae) that acts as a signal for their retrieval from subsequent compartments of the secretory pathway. The receptor for this signal is a ~26kDa Golgi membrane protein, initially identified as the ERD2 gene product in S. cerevisiae. The receptor molecule, known variously as the ER lumen protein retaining receptor or the 'KDEL receptor', is believed to cycle between the cis side of the Golgi apparatus and the ER. It has also been characterised in a number of other species, including plants, Plasmodium, Drosophila and mammals. In mammals, 2 highly related forms of the receptor are known.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein retention in ER lumen | The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Molecular function | ER retention sequence binding | Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ER lumen protein retaining receptor-like [Glycine max] gi|356517923|ref|XP_003527635.1| | 9 | ||
| – | PREDICTED: ER lumen protein retaining receptor-like [Glycine max] gi|356508031|ref|XP_003522766.1| | 9 | ||
| – | PREDICTED: ER lumen protein retaining receptor-like [Glycine max] gi|356544080|ref|XP_003540483.1| | 9 | ||
| – | PREDICTED: ER lumen protein retaining receptor-like [Cicer arietinum] gi|502140615|ref|XP_004504277.1| | 16 | ||
| – | ER lumen protein retaining receptor; TAIR: AT1G75760.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|O76767|ERD2_DROME ER lumen protein-retaining receptor; TrEMBL-Plants: tr|I3SZ51|I3SZ51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0429100 | 9 | ||
| – | ER lumen protein retaining receptor; TAIR: AT1G75760.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|Q86JE5|ERD2_DICDI ER lumen protein-retaining receptor; TrEMBL-Plants: tr|I3SZ51|I3SZ51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0429100 | 9 | ||
| – | ER lumen protein retaining receptor; TAIR: AT1G75760.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|Q86JE5|ERD2_DICDI ER lumen protein-retaining receptor; TrEMBL-Plants: tr|I3SZ51|I3SZ51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0429100 | 8 | ||
| – | ER lumen protein retaining receptor; TAIR: AT2G21190.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|Q09473|ERD22_CAEEL Putative ER lumen protein-retaining receptor C28H8.4; TrEMBL-Plants: tr|A0A1J7HPK1|A0A1J7HPK1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0560600 | 9 | ||
| – | ER lumen protein-retaining receptor; TAIR: AT3G25040.1 endoplasmic reticulum retention defective 2B; Swiss-Prot: sp|Q8VWI1|ERD2B_ARATH ER lumen protein-retaining receptor B; TrEMBL-Plants: tr|I3SXL4|I3SXL4_LOTJA ER lumen protein-retaining receptor; Found in the gene: LotjaGi1g1v0588200 | 15 | ||
| – | ER lumen protein-retaining receptor; TAIR: AT3G25040.1 endoplasmic reticulum retention defective 2B; Swiss-Prot: sp|Q8VWI1|ERD2B_ARATH ER lumen protein-retaining receptor B; TrEMBL-Plants: tr|I3SXL4|I3SXL4_LOTJA ER lumen protein-retaining receptor; Found in the gene: LotjaGi1g1v0588200 | 16 | ||
| – | ER lumen protein retaining receptor; TAIR: AT3G25160.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|P35402|ERD2A_ARATH ER lumen protein-retaining receptor A; TrEMBL-Plants: tr|I3SII9|I3SII9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0086600 | 9 | ||
| – | ER lumen protein retaining receptor; TAIR: AT3G25160.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|Q8VWI1|ERD2B_ARATH ER lumen protein-retaining receptor B; TrEMBL-Plants: tr|I3SII9|I3SII9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0086700 | 9 | ||
| – | ER lumen protein retaining receptor; TAIR: AT3G25160.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|Q8VWI1|ERD2B_ARATH ER lumen protein-retaining receptor B; TrEMBL-Plants: tr|I1JM56|I1JM56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0086900 | 9 | ||
| – | ER lumen protein retaining receptor-like protein; TAIR: AT2G21190.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|P48583|ERD2_CAEEL ER lumen protein-retaining receptor; TrEMBL-Plants: tr|I3SDS4|I3SDS4_MEDTR ER lumen protein retaining receptor-like protein; Found in the gene: LotjaGi3g1v0532400 | 9 | ||
| – | ER lumen protein retaining receptor-like protein; TAIR: AT1G75760.3 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|P48583|ERD2_CAEEL ER lumen protein-retaining receptor; TrEMBL-Plants: tr|I3SDS4|I3SDS4_MEDTR ER lumen protein retaining receptor-like protein; Found in the gene: LotjaGi3g1v0532400 | 9 | ||
| – | ER lumen protein-retaining receptor; TAIR: AT1G29330.1 ER lumen protein retaining receptor family protein; Swiss-Prot: sp|P35402|ERD2A_ARATH ER lumen protein-retaining receptor A; TrEMBL-Plants: tr|I1KSH4|I1KSH4_SOYBN ER lumen protein-retaining receptor; Found in the gene: LotjaGi4g1v0380500 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 6.25 |