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IPR000692

Source: InterPro

Description

IPR000692 is a rRNA 2'-O-methyltransferase fibrillarin-like.

<p>Fibrillarin (rRNA 2'-O-methyltransferase fibrillarin) is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP) [[cite:PUB00003067], [cite:PUB00004418]]. It is a S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Site specificity is provided by a guide RNA that base pairs with the substrate and methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA [[cite:PUB00100521], [cite:PUB00100520], [cite:PUB00100523], [cite:PUB00001181], [cite:PUB00100522]]. Fibrillarin is associated with U3, U8 and U13 small nuclear RNAs in mammals [[cite:PUB00003067]] and is similar to the yeast NOP1 protein [[cite:PUB00001181]]. It has a well conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensus sequence; and a C-terminal α-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaebacteria.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:0006364
Biological process RRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
Subterm of
Part of
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj0g3v0107099.1
– PREDICTED: rRNA 2'-O-methyltransferase fibrillarin 2-like [Glycine max] gi|356518852|ref|XP_003528091.1|
Domains
13
Lj0g3v0201389.1
– Fibrillarin [Medicago truncatula] gi|357444829|ref|XP_003592692.1|
Domains
13
Lj5g3v0391280.1
– RRNA 2'-O-methyltransferase fibrillarin 2 [Triticum urartu] gi|473947937|gb|EMS50585.1|
Domains
13
LotjaGi1g1v0018400.1
– RRNA 2'-O-methyltransferase fibrillarin 2; TAIR: AT4G25630.1 fibrillarin 2; Swiss-Prot: sp|Q94AH9|MD36A_ARATH Mediator of RNA polymerase II transcription subunit 36a; TrEMBL-Plants: tr|I3SKZ0|I3SKZ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0018400
Domains
15
LotjaGi1g1v0018400.2
– RRNA 2'-O-methyltransferase fibrillarin 2; TAIR: AT4G25630.1 fibrillarin 2; Swiss-Prot: sp|Q94AH9|MD36A_ARATH Mediator of RNA polymerase II transcription subunit 36a; TrEMBL-Plants: tr|I3SKZ0|I3SKZ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0018400
Domains
14
LotjaGi1g1v0018400.3
– RRNA 2'-O-methyltransferase fibrillarin 2; TAIR: AT4G25630.1 fibrillarin 2; Swiss-Prot: sp|Q94AH9|MD36A_ARATH Mediator of RNA polymerase II transcription subunit 36a; TrEMBL-Plants: tr|I3SKZ0|I3SKZ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0018400
Domains
14
LotjaGi2g1v0122000.1
– RRNA 2'-O-methyltransferase fibrillarin 2; TAIR: AT4G25630.1 fibrillarin 2; Swiss-Prot: sp|Q94AH9|MD36A_ARATH Mediator of RNA polymerase II transcription subunit 36a; TrEMBL-Plants: tr|I3SKZ0|I3SKZ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0122000
Domains
15
LotjaGi5g1v0041200.1
– RRNA 2'-O-methyltransferase fibrillarin 2; TAIR: AT5G52470.1 fibrillarin 1; Swiss-Prot: sp|Q9FEF8|MD36B_ARATH Probable mediator of RNA polymerase II transcription subunit 36b; TrEMBL-Plants: tr|A0A072U8T6|A0A072U8T6_MEDTR Mediator of RNA polymerase II transcription subunit 36a; Found in the gene: LotjaGi5g1v0041200
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53335 SUPERFAMILY 1 12.50