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IPR001098 is a DNA-directed DNA polymerase, family A, palm domain.
<p>Synonym(s): DNA nucleotidyltransferase (DNA-directed) <p>DNA-directed DNA polymerases([ec:2.7.7.7]) are the key enzymes catalysing the accurate replication of DNA. They require either a small RNA molecule or a protein as a primer for the<i>de novo</i>synthesis of a DNA chain. A number of polymerases belong to this family [[cite:PUB00004955], [cite:PUB00004393], [cite:PUB00004443]].</p> <p>DNA-dependent DNA polymerases can be classified into six main groups based upon phylogenetic relationships with E. coli polymerase I (classA), E. coli polymerase II (class B), E.coli polymerase III (class C), euryarchaeota polymerase II (class D), human polymerase beta (class X), E. coli UmuC/DinB and eukaryotic RAP 30/Xeroderma pigmentosum variant (class Y). The structure of these polymerases resembles in overall morphology a cupped human right hand, with fingers (which bind an incoming nucleotide and interact with the single-stranded template), palm (which harbors the catalytic amino acid residues and also binds an incoming dNTP) and thumb (which binds double-stranded DNA) subdomains [[cite:PUB00092104]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA polymerase [Medicago truncatula] gi|357459413|ref|XP_003599987.1| | 13 | ||
| – | PREDICTED: DNA polymerase I-like [Glycine max] gi|356500355|ref|XP_003518998.1| | 10 | ||
| – | DNA polymerase [Medicago truncatula] gi|357494395|ref|XP_003617486.1| | 6 | ||
| – | PREDICTED: DNA polymerase theta-like [Cicer arietinum] gi|502124469|ref|XP_004498542.1| | 16 | ||
| – | DNA polymerase [Medicago truncatula] gi|357494395|ref|XP_003617486.1| | 12 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7K3G7|G7K3G7_MEDTR PolI-like B DNA polymerase; Found in the gene: LotjaGi1g1v0035300_LC | 10 | ||
| – | DNA helicase; TAIR: AT4G32700.2 MUS308 and mammalian DNA polymerase-like protein; Swiss-Prot: sp|Q588V7|TEB_ARATH Helicase and polymerase-containing protein TEBICHI; TrEMBL-Plants: tr|K7M6P7|K7M6P7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198600 | 33 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 26 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 26 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 14 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J1V4|G7J1V4_MEDTR PolI-like B DNA polymerase; Found in the gene: LotjaGi6g1v0163900 | 20 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0B2NWI0|A0A0B2NWI0_GLYSO DNA polymerase I; Found in the gene: LotjaGi6g1v0163900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |