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IPR002298 is a DNA polymerase A.
<p>DNA carries the biological information that instructs cells how to exist in an ordered fashion. Accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing DNA chain, using a complementary DNA as template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used. DNA-dependent DNA polymerases have been grouped into families, denoted A, B and X, on the basis of sequence similarities [[cite:PUB00004647], [cite:PUB00004955]]. Members of family A, which includes bacterial and bacteriophage polymerases, share significant similarity to Escherichia coli polymerase I; hence family A is also known as the pol I family. The bacterial polymerases also contain an exonuclease activity, which is coded for in the N-terminal portion. Three motifs, A, B and C [[cite:PUB00004955]], are seen to be conserved across all DNA polymerases, with motifs A and C also seen in RNA polymerases. They are centred on invariant residues, and their structural significance was implied from the Klenow (E. coli) structure. Motif A contains a strictly-conserved aspartate at the junction of a β-strand and an α-helix; motif B contains an α-helix with positive charges; and motif C has a doublet of negative charges, located in a β-turn-beta secondary structure [[cite:PUB00004955]].</p> <p>This entry represents the DNA-polymerase A family.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. | ||
| Biological process | DNA-dependent DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA polymerase [Medicago truncatula] gi|357459413|ref|XP_003599987.1| | 13 | ||
| – | PREDICTED: DNA polymerase I-like [Glycine max] gi|356500355|ref|XP_003518998.1| | 10 | ||
| – | PREDICTED: DNA polymerase theta-like [Cicer arietinum] gi|502124469|ref|XP_004498542.1| | 16 | ||
| – | DNA polymerase [Medicago truncatula] gi|357494395|ref|XP_003617486.1| | 12 | ||
| – | DNA polymerase; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0B2PWM4|A0A0B2PWM4_GLYSO DNA polymerase I; Found in the gene: LotjaGi1g1v0034300_LC | 5 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7K3G7|G7K3G7_MEDTR PolI-like B DNA polymerase; Found in the gene: LotjaGi1g1v0035300_LC | 10 | ||
| – | DNA helicase; TAIR: AT4G32700.2 MUS308 and mammalian DNA polymerase-like protein; Swiss-Prot: sp|Q588V7|TEB_ARATH Helicase and polymerase-containing protein TEBICHI; TrEMBL-Plants: tr|K7M6P7|K7M6P7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198600 | 33 | ||
| – | 5'-3' exonuclease; TAIR: AT1G34380.2 5'-3' exonuclease family protein; Swiss-Prot: sp|O67550|EX53_AQUAE 5'-3' exonuclease; TrEMBL-Plants: tr|K7MHK5|K7MHK5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0098200 | 16 | ||
| – | Flap endonuclease Xni; TAIR: AT3G52050.1 5'-3' exonuclease family protein; Swiss-Prot: sp|O52225|DPO1_THEFI DNA polymerase I, thermostable; TrEMBL-Plants: tr|A0A0S3R340|A0A0S3R340_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0069300 | 19 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 26 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 26 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151U285|A0A151U285_CAJCA DNA polymerase I; Found in the gene: LotjaGi4g1v0197800 | 14 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7J1V4|G7J1V4_MEDTR PolI-like B DNA polymerase; Found in the gene: LotjaGi6g1v0163900 | 20 | ||
| – | DNA polymerase I; TAIR: AT1G50840.1 polymerase gamma 2; Swiss-Prot: sp|F4I6M1|POLIA_ARATH DNA polymerase I A, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0B2NWI0|A0A0B2NWI0_GLYSO DNA polymerase I; Found in the gene: LotjaGi6g1v0163900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.14 |