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IPR002490 is a V-type ATPase, V0 complex, 116kDa subunit family.
<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra-and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release [[cite:PUB00020609]]. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [[cite:PUB00020608]].</p> <p>This entry represents the 116kDa subunit (or subunit a) found in the V0 complex of V-ATPases, respectively. The 116kDa subunit is a transmembrane glycoprotein required for the assembly and proton transport activity of the ATPase complex. Several isoforms of the 116kDa subunit exist, providing a potential role in the differential targeting and regulation of the V-ATPase for specific organelles [[cite:PUB00020646]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Proton transmembrane transporter activity | Enables the transfer of a proton from one side of a membrane to the other. | ||
| Cellular component | Proton-transporting V-type ATPase, V0 domain | A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. | ||
| Biological process | Proton transmembrane transport | The directed movement of a proton across a membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356547204|ref|XP_003542006.1| | 3 | ||
| – | PREDICTED: vacuolar proton ATPase a1-like [Cicer arietinum] gi|502082366|ref|XP_004487144.1| | 5 | ||
| – | PREDICTED: vacuolar proton ATPase a1-like [Cicer arietinum] gi|502082366|ref|XP_004487144.1| | 5 | ||
| – | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356558433|ref|XP_003547511.1| | 11 | ||
| – | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356558433|ref|XP_003547511.1| | 8 | ||
| – | 3 | |||
| – | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 13 | ||
| – | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 8 | ||
| – | CM0216.490.nc [Lotus japonicus] gi|164605517|dbj|BAF98583.1| | 5 | ||
| – | V-type proton ATPase 116 kDa subunit a isoform [Medicago truncatula] gi|357473431|ref|XP_003607000.1| | 4 | ||
| – | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356542569|ref|XP_003539739.1| | 9 | ||
| – | PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Glycine max] gi|356542569|ref|XP_003539739.1| | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|A0A151RQM9|A0A151RQM9_CAJCA V-type proton ATPase subunit a; Found in the gene: LotjaGi1g1v0424500 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G21410.1 vacuolar proton ATPase A2; Swiss-Prot: sp|Q9SJT7|VHAA2_ARATH V-type proton ATPase subunit a2; TrEMBL-Plants: tr|I1K7M8|I1K7M8_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi1g1v0424500 | 8 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|I1LR08|I1LR08_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi2g1v0364600 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 8 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 8 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A1J7GFZ0|A0A1J7GFZ0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0364600 | 8 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0R0H303|A0A0R0H303_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi2g1v0364600 | 9 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|K7M9K9|K7M9K9_SOYBN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0S3SGJ3|A0A0S3SGJ3_PHAAN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|A0A0S3SGJ3|A0A0S3SGJ3_PHAAN V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT2G28520.1 vacuolar proton ATPase A1; Swiss-Prot: sp|Q8RWZ7|VHAA1_ARATH V-type proton ATPase subunit a1; TrEMBL-Plants: tr|V7BYX1|V7BYX1_PHAVU V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0273900 | 8 | ||
| – | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|B0BL94|B0BL94_LOTJA V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0512800 | 11 | ||
| – | V-type proton ATPase subunit a; TAIR: AT4G39080.1 vacuolar proton ATPase A3; Swiss-Prot: sp|Q8W4S4|VHAA3_ARATH V-type proton ATPase subunit a3; TrEMBL-Plants: tr|B0BL94|B0BL94_LOTJA V-type proton ATPase subunit a; Found in the gene: LotjaGi3g1v0512800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 4.00 |