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IPR004148 is a BAR domain.
<p>Endocytosis and intracellular transport involve several mechanistic steps:</p> <ol> <li>For the internalisation of cargo molecules, the membrane needs to bend to form a vesicular structure, which requires membrane curvature and a rearrangement of the cytoskeleton;</li> <li>Following its formation, the vesicle has to be pinched off the membrane;</li> <li>The cargo has to be subsequently transported through the cell and the vesicle must fuse with the correct cellular compartment.</li> </ol> <p>Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis, involved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain, known as the BAR (Bin-Amphiphysin-Rvs)-domain, which is required for their<i>in vivo</i>function and their ability to tubulate membranes [[cite:PUB00014978]].</p> <p>The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic, aromatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise, heterodimerise or, in a few cases, interact with small GTPases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like [Glycine max] gi|356523716|ref|XP_003530481.1| | 34 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD2-like [Glycine max] gi|356544659|ref|XP_003540765.1| | 32 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|I1JXQ4|I1JXQ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0333600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|V7CU24|V7CU24_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0629500 | 10 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|A0A0L9U6Q1|A0A0L9U6Q1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0629500 | 10 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT1G60860.1 ARF-GAP domain 2; Swiss-Prot: sp|Q9C6C3|AGD2_ARATH ADP-ribosylation factor GTPase-activating protein AGD2; TrEMBL-Plants: tr|K7LSS6|K7LSS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0524900 | 35 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|G7LIT7|G7LIT7_MEDTR ADP-ribosylation factor GTPase-activating protein AGD10; Found in the gene: LotjaGi4g1v0421700 | 36 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |