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IPR001164 is a Arf GTPase activating protein.
<p>Proteins containing this domain include ARF1-directed GTPase-activating protein, the cycle control GTPase activating protein (GAP) GCS1 which is important for the regulation of the ADP ribosylation factor ARF, a member of the Ras superfamily of GTP-binding proteins [[cite:PUB00003022]]. The GTP-bound form of ARF is essential for the maintenance of normal Golgi morphology, it participates in recruitment of coat proteins which are required for budding and fission of membranes. Before the fusion with an acceptor compartment the membrane must be uncoated. This step required the hydrolysis of GTP associated to ARF. These proteins contain a characteristic zinc finger motif (Cys-x2-Cys-x(16,17)-x2-Cys) which displays some similarity to the C4-type GATA zinc finger. The ARFGAP domain display no obvious similarity to other GAP proteins.</p> <p>The 3D structure of the ARFGAP domain of the PYK2-associated protein beta has been solved [[cite:PUB00014900]]. It consists of a three-stranded β-sheet surrounded by 5 α helices. The domain is organised around a central zinc atom which is coordinated by 4 cysteines. The ARFGAP domain is clearly unrelated to the other GAP proteins structures which are exclusively helical. Classical GAP proteins accelerate GTPase activity by supplying an arginine finger to the active site. The crystal structure of ARFGAP bound to ARF revealed that the ARFGAP domain does not supply an arginine to the active site which suggests a more indirect role of the ARFGAP domain in the GTPase hydrolysis [[cite:PUB00014901]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD5-like isoform X3 [Cicer arietinum] gi|502179540|ref|XP_004516449.1| | 8 | ||
| – | Aspartate aminotransferase, partial [Prunus persica] gi|452090864|gb|AGF95103.1| | 7 | ||
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD11-like isoform X3 [Cicer arietinum] gi|502168829|ref|XP_004514475.1| | 16 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like [Glycine max] gi|356511534|ref|XP_003524480.1| | 13 | ||
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD13-like isoform X1 [Cicer arietinum] gi|502080093|ref|XP_004486456.1| | 7 | ||
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD8-like [Glycine max] gi|356526713|ref|XP_003531961.1| | 9 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD1-like [Cicer arietinum] gi|502133396|ref|XP_004501749.1| | 17 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD1-like [Cicer arietinum] gi|502133396|ref|XP_004501749.1| | 26 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like [Glycine max] gi|356523716|ref|XP_003530481.1| | 34 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD7-like [Glycine max] gi|356572329|ref|XP_003554321.1| | 9 | ||
| – | 8 | |||
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD14-like isoform X2 [Cicer arietinum] gi|502163814|ref|XP_004512958.1| | 9 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD2-like [Glycine max] gi|356544659|ref|XP_003540765.1| | 32 | ||
| – | PREDICTED: probable ADP-ribosylation factor GTPase-activating protein AGD14-like isoform X1 [Cicer arietinum] gi|502163481|ref|XP_004512853.1| | 12 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD7-like isoform X1 [Cicer arietinum] gi|502114640|ref|XP_004495006.1| | 9 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|I1JXQ4|I1JXQ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0333600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT3G53710.1 ARF-GAP domain 6; Swiss-Prot: sp|Q9M354|AGD6_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD6; TrEMBL-Plants: tr|I1N9Z5|I1N9Z5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0699400 | 13 | ||
| – | ARF-GAP domain 1; TAIR: AT1G08680.4 ARF GAP-like zinc finger-containing protein ZIGA4; Swiss-Prot: sp|Q8RXE7|AGD14_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD14; TrEMBL-Plants: tr|A0A0B2PC95|A0A0B2PC95_GLYSO Putative ADP-ribosylation factor GTPase-activating protein AGD14; Found in the gene: LotjaGi2g1v0092300 | 13 | ||
| – | Arf GTPase activating protein; TAIR: AT3G17660.1 ARF-GAP domain 15; Swiss-Prot: sp|Q0WQQ1|AGD15_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD15; TrEMBL-Plants: tr|K7LEB1|K7LEB1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0181600 | 12 | ||
| – | ARF-GAP domain 1; TAIR: AT4G13350.1 NSP (nuclear shuttle protein)-interacting GTPase; Swiss-Prot: sp|Q8RXE7|AGD14_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD14; TrEMBL-Plants: tr|K7LER1|K7LER1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0213100 | 13 | ||
| – | Calcium-dependent ARF-type GTPase activating family protein; TAIR: AT3G07940.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q8L7A4|AGD11_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD11; TrEMBL-Plants: tr|K7LQK9|K7LQK9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0111800 | 21 | ||
| – | Calcium-dependent ARF-type GTPase activating family protein; TAIR: AT3G07940.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q8L7A4|AGD11_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD11; TrEMBL-Plants: tr|A0A0B2QNN2|A0A0B2QNN2_GLYSO Putative ADP-ribosylation factor GTPase-activating protein AGD11; Found in the gene: LotjaGi3g1v0111800 | 21 | ||
| – | Arf GTPase activating protein; TAIR: AT3G07940.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q8L7A4|AGD11_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD11; TrEMBL-Plants: tr|V7AJK2|V7AJK2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0320100 | 21 | ||
| – | Arf GTPase activating protein; TAIR: AT5G54310.1 ARF-GAP domain 5; Swiss-Prot: sp|Q9FL69|AGD5_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD5; TrEMBL-Plants: tr|C6T8G3|C6T8G3_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0323000 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT1G60860.1 ARF-GAP domain 2; Swiss-Prot: sp|Q9C6C3|AGD2_ARATH ADP-ribosylation factor GTPase-activating protein AGD2; TrEMBL-Plants: tr|K7LSS6|K7LSS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0524900 | 35 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT4G17890.1 ARF-GAP domain 8; Swiss-Prot: sp|Q8H100|AGD8_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD8; TrEMBL-Plants: tr|I1KX25|I1KX25_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0171100 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT4G17890.1 ARF-GAP domain 8; Swiss-Prot: sp|Q8H100|AGD8_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD8; TrEMBL-Plants: tr|I1KX25|I1KX25_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0171200 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT4G17890.1 ARF-GAP domain 8; Swiss-Prot: sp|Q8H100|AGD8_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD8; TrEMBL-Plants: tr|I1KX26|I1KX26_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0171200 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein AGD12; TAIR: AT4G21160.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q9FVJ3|AGD12_ARATH ADP-ribosylation factor GTPase-activating protein AGD12; TrEMBL-Plants: tr|I1K469|I1K469_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0385500 | 20 | ||
| – | ADP-ribosylation factor GTPase-activating protein AGD12; TAIR: AT4G21160.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q9FVJ3|AGD12_ARATH ADP-ribosylation factor GTPase-activating protein AGD12; TrEMBL-Plants: tr|G7L835|G7L835_MEDTR ADP-ribosylation factor GTPase-activating protein AGD10; Found in the gene: LotjaGi4g1v0385500 | 20 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|I1K6T3|I1K6T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421700 | 28 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|I1K6T3|I1K6T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421700 | 28 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|G7LIT7|G7LIT7_MEDTR ADP-ribosylation factor GTPase-activating protein AGD10; Found in the gene: LotjaGi4g1v0421700 | 36 | ||
| – | ARF-GAP domain 1; TAIR: AT4G13350.1 NSP (nuclear shuttle protein)-interacting GTPase; Swiss-Prot: sp|Q8RXE7|AGD14_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD14; TrEMBL-Plants: tr|I1KQ36|I1KQ36_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0450800 | 13 | ||
| – | ARF-GAP domain 1; TAIR: AT4G32630.1 ArfGap/RecO-like zinc finger domain-containing protein; Swiss-Prot: sp|Q8RXE7|AGD14_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD14; TrEMBL-Plants: tr|K7M6G7|K7M6G7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0063400 | 13 | ||
| – | ARF-GAP domain 1; TAIR: AT4G13350.1 NSP (nuclear shuttle protein)-interacting GTPase; Swiss-Prot: sp|Q8RXE7|AGD14_ARATH Probable ADP-ribosylation factor GTPase-activating protein AGD14; TrEMBL-Plants: tr|K7M6G7|K7M6G7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0063400 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT2G37550.1 ARF-GAP domain 7; Swiss-Prot: sp|O80925|AGD7_ARATH ADP-ribosylation factor GTPase-activating protein AGD7; TrEMBL-Plants: tr|Q2PER6|Q2PER6_TRIPR Putative Asp1; Found in the gene: LotjaGi5g1v0067500 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein AGD12; TAIR: AT4G21160.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q9FVJ3|AGD12_ARATH ADP-ribosylation factor GTPase-activating protein AGD12; TrEMBL-Plants: tr|G7IKU9|G7IKU9_MEDTR ADP-ribosylation factor GTPase-activating protein AGD10; Found in the gene: LotjaGi6g1v0271400 | 20 | ||
| – | ADP-ribosylation factor GTPase-activating protein AGD12; TAIR: AT4G21160.1 Calcium-dependent ARF-type GTPase activating protein family; Swiss-Prot: sp|Q9FVJ3|AGD12_ARATH ADP-ribosylation factor GTPase-activating protein AGD12; TrEMBL-Plants: tr|A0A151T618|A0A151T618_CAJCA ADP-ribosylation factor GTPase-activating protein AGD12; Found in the gene: LotjaGi6g1v0271400 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08204 | CDD | 1 | 2.44 |