Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027267 is a AH/BAR domain superfamily.
<p>This superfamily represents a structural domain which consists of three α-helices, including the arfaptin homology (AH) domain and the BAR (Bin-Amphiphysin-Rvs) domain.</p> <p>The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 [[cite:PUB00018335]] and mammalian 69kDa islet cell autoantigen (ICA69) [[cite:PUB00012613]]. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [[cite:PUB00012612], [cite:PUB00018336]], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The AH domain consists of three α-helices arranged as an extended antiparallel α-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [[cite:PUB00012612], [cite:PUB00018336]].</p> <p>Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis, involved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain, known as the BAR (Bin-Amphiphysin-Rvs) domain, which is required for their<i>in vivo</i>function and their ability to tubulate membranes [[cite:PUB00014978]]. The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic, aromatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise, heterodimerise or, in a few cases, interact with small GTPases.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ADP-ribosylation factor GTPase-activating protein [Medicago truncatula] gi|357520601|ref|XP_003630589.1| | 12 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like [Glycine max] gi|356523716|ref|XP_003530481.1| | 34 | ||
| – | Hydroxyproline-rich glycoprotein family protein [Theobroma cacao] gi|508710989|gb|EOY02886.1| | 8 | ||
| – | PREDICTED: intersectin-1-like isoform X1 [Cicer arietinum] gi|502130808|ref|XP_004500776.1| | 12 | ||
| – | Hydroxyproline-rich glycoprotein family protein [Theobroma cacao] gi|508710989|gb|EOY02886.1| | 6 | ||
| – | Rho guanine nucleotide exchange factor [Medicago truncatula] gi|357484541|ref|XP_003612558.1| | 13 | ||
| – | Sorting nexin-1 [Medicago truncatula] gi|357492829|ref|XP_003616703.1| | 9 | ||
| – | PREDICTED: intersectin-1-like isoform X3 [Cicer arietinum] gi|502149376|ref|XP_004507503.1| | 12 | ||
| – | PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD2-like [Glycine max] gi|356544659|ref|XP_003540765.1| | 32 | ||
| – | PREDICTED: intersectin-2-like [Cicer arietinum] gi|502140518|ref|XP_004504244.1| | 12 | ||
| – | Sorting nexin; TAIR: AT5G58440.1 sorting nexin 2A; Swiss-Prot: sp|Q8L5Z7|SNX2A_ARATH Sorting nexin 2A; TrEMBL-Plants: tr|G7K781|G7K781_MEDTR Sorting nexin 2B; Found in the gene: LotjaGi1g1v0073300 | 17 | ||
| – | Sorting nexin; TAIR: AT5G07120.1 sorting nexin 2B; Swiss-Prot: sp|B9DFS6|SNX2B_ARATH Sorting nexin 2B; TrEMBL-Plants: tr|G7JZQ0|G7JZQ0_MEDTR Sorting nexin 2B; Found in the gene: LotjaGi1g1v0114300 | 18 | ||
| – | Sorting nexin; TAIR: AT5G07120.1 sorting nexin 2B; Swiss-Prot: sp|B9DFS6|SNX2B_ARATH Sorting nexin 2B; TrEMBL-Plants: tr|A0A0L9UWY0|A0A0L9UWY0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0114300 | 18 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|I1JXQ4|I1JXQ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0333600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G13300.1 ARF GTPase-activating protein; Swiss-Prot: sp|Q5W7F2|AGD3_ARATH ADP-ribosylation factor GTPase-activating protein AGD3; TrEMBL-Plants: tr|A0A151TCR5|A0A151TCR5_CAJCA ADP-ribosylation factor GTPase-activating protein AGD3; Found in the gene: LotjaGi1g1v0528600 | 37 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|K7MVM2|K7MVM2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555300 | 9 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|K7MVM2|K7MVM2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555300 | 9 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|G7J7R7|G7J7R7_MEDTR Clathrin-binding protein; Found in the gene: LotjaGi1g1v0563900 | 13 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|G7J7R7|G7J7R7_MEDTR Clathrin-binding protein; Found in the gene: LotjaGi1g1v0563900 | 13 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|V7CU24|V7CU24_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0629500 | 10 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|A0A151SM30|A0A151SM30_CAJCA Uncharacterized protein family; Found in the gene: LotjaGi1g1v0629500 | 8 | ||
| – | Hydroxyproline-rich glycoprotein family protein; TAIR: AT2G33490.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|O22799|Y2349_ARATH Uncharacterized protein At2g33490; TrEMBL-Plants: tr|A0A0L9U6Q1|A0A0L9U6Q1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0629500 | 10 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|I1J846|I1J846_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0345400 | 14 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7HPY7|A0A1J7HPY7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0513900 | 13 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7HPY7|A0A1J7HPY7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0513900 | 13 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G34660.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8VWF1|SH3P2_ARATH SH3 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7HPY7|A0A1J7HPY7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0513900 | 13 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT1G60860.1 ARF-GAP domain 2; Swiss-Prot: sp|Q9C6C3|AGD2_ARATH ADP-ribosylation factor GTPase-activating protein AGD2; TrEMBL-Plants: tr|K7LSS6|K7LSS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0524900 | 35 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G18060.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8L7W0|SH3P3_ARATH SH3 domain-containing protein 3; TrEMBL-Plants: tr|I3SJQ0|I3SJQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0382800 | 13 | ||
| – | SH3 domain-containing protein 1; TAIR: AT4G18060.1 SH3 domain-containing protein; Swiss-Prot: sp|Q8L7W0|SH3P3_ARATH SH3 domain-containing protein 3; TrEMBL-Plants: tr|I3SJQ0|I3SJQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0382800 | 14 | ||
| – | ADP-ribosylation factor GTPase-activating protein; TAIR: AT5G61980.1 ARF-GAP domain 1; Swiss-Prot: sp|Q9FIT8|AGD1_ARATH ADP-ribosylation factor GTPase-activating protein AGD1; TrEMBL-Plants: tr|G7LIT7|G7LIT7_MEDTR ADP-ribosylation factor GTPase-activating protein AGD10; Found in the gene: LotjaGi4g1v0421700 | 36 | ||
| – | Sorting nexin 1; TAIR: AT5G06140.1 sorting nexin 1; Swiss-Prot: sp|Q9FG38|SNX1_ARATH Sorting nexin 1; TrEMBL-Plants: tr|C6TEZ3|C6TEZ3_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0099300 | 19 | ||
| – | Sorting nexin 1; TAIR: AT5G06140.1 sorting nexin 1; Swiss-Prot: sp|Q9FG38|SNX1_ARATH Sorting nexin 1; TrEMBL-Plants: tr|K7K9Q0|K7K9Q0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0099300 | 13 | ||
| – | Sorting nexin 1; TAIR: AT5G06140.1 sorting nexin 1; Swiss-Prot: sp|Q9FG38|SNX1_ARATH Sorting nexin 1; TrEMBL-Plants: tr|C6TEZ3|C6TEZ3_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0099300 | 18 | ||
| – | Sorting nexin 1; TAIR: AT5G06140.1 sorting nexin 1; Swiss-Prot: sp|Q9FG38|SNX1_ARATH Sorting nexin 1; TrEMBL-Plants: tr|A0A0B2SME9|A0A0B2SME9_GLYSO Sorting nexin 1; Found in the gene: LotjaGi5g1v0099300 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 2.86 |