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IPR005747 is a Endonuclease MutS2.
<p>The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair. Homologues of MutS have been found in many species including eukaryotes (MSH 1, 2, 3, 4, 5, and 6 proteins), archaea and bacteria, and together these proteins have been grouped into the MutS family. Although many of these proteins have similar activities to the E. coli MutS, there is significant diversity of function among the MutS family members. Inter-species homologues may have arisen through frequent ancient horizontal gene transfer of MutS (and MutL) from bacteria to archaea and eukaryotes via endosymbiotic ancestors of mitochondria and chloroplasts [[cite:PUB00042615]].</p> <p>This entry represents endonuclease MutS2. MutS2 is a paralogue of MutS and is not involved in DNA mismatch repair but in the suppression of homologous recombination [[cite:PUB00068032], [cite:PUB00068033], [cite:PUB00050421], [cite:PUB00068769]]. It may therefore have a key role in the control of bacterial genetic diversity.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. | ||
| Molecular function | ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. | ||
| Molecular function | Mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. | ||
| Biological process | Negative regulation of DNA recombination | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: mutS2 protein-like isoform X2 [Cicer arietinum] gi|502095766|ref|XP_004490532.1| | 15 | ||
| – | PREDICTED: mutS2 protein-like isoform X2 [Cicer arietinum] gi|502095766|ref|XP_004490532.1| | 16 | ||
| – | PREDICTED: mutS2 protein-like isoform 1 [Glycine max] gi|356521349|ref|XP_003529319.1| | 21 | ||
| – | PREDICTED: mutS2 protein-like isoform 1 [Glycine max] gi|356521349|ref|XP_003529319.1| | 21 | ||
| – | DNA mismatch repair MUTS family protein; TAIR: AT5G54090.1 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1JH75|I1JH75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0127700 | 17 | ||
| – | DNA mismatch repair MUTS family protein; TAIR: AT5G54090.1 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1JH75|I1JH75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0127700 | 17 | ||
| – | DNA mismatch repair protein MutS2; TAIR: AT1G65070.2 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1KLI9|I1KLI9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055400 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |