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IPR013128 is a Peptidase C1A.
<p>This group of cysteine peptidases belong to MEROPS peptidase family C1, sub-family C1A (papain family, clan CA). It includes related cysteine proteinases such as actinidin [[cite:PUB00000685]]. This entry also includes proteins classed as non-peptidase homologues such as the catalytically inactive tubulointerstitial nephritis antigen (TIN-Ag) [[cite:PUB00101803]]. These have either been shown experimentally to lack peptidase activity or lack one or more of the active site residues.</p> <p>The papain family has a wide variety of activities, including broad-range (papain) and narrow-range endo-peptidases, aminopeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity [[cite:PUB00003577]]. Members of the papain family are widespread, found in baculovirus [[cite:PUB00000522]], eubacteria, yeast, and practically all protozoa, plants and mammals [[cite:PUB00003577]]. The proteins are typically lysosomal or secreted, and proteolytic cleavage of the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals [[cite:PUB00000287]]. Papain-like cysteine proteinases are essentially synthesised as inactive proenzymes (zymogens) with N-terminal propeptide regions. The activation process of these enzymes includes the removal of propeptide regions. The propeptide regions serve a variety of functions in vivo and in vitro. The pro-region is required for the proper folding of the newly synthesised enzyme, the inactivation of the peptidase domain and stabilisation of the enzyme against denaturing at neutral to alkaline pH conditions. Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme to lysosomes. Among the most notable features of propeptides is their ability to inhibit the activity of their cognate enzymes and that certain propeptides exhibit high selectivity for inhibition of the peptidases from which they originate [[cite:PUB00015451]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cysteine proteinase [Lotus japonicus] gi|144905112|dbj|BAF56429.1| | 16 | ||
| – | PREDICTED: cathepsin B-like [Glycine max] gi|356572872|ref|XP_003554589.1| | 24 | ||
| – | Senescence-associated gene 12 [Theobroma cacao] gi|508702326|gb|EOX94222.1| | 24 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: xylem cysteine proteinase 1-like [Cicer arietinum] gi|502078248|ref|XP_004485885.1| | 26 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|409190991|gb|AFV30165.1| | 15 | ||
| – | PREDICTED: KDEL-tailed cysteine endopeptidase CEP2-like [Cicer arietinum] gi|502143938|ref|XP_004505522.1| | 14 | ||
| – | PREDICTED: cysteine proteinase 15A [Glycine max] gi|356564325|ref|XP_003550405.1| | 15 | ||
| – | PREDICTED: cysteine proteinase 15A [Glycine max] gi|356564325|ref|XP_003550405.1| | 11 | ||
| – | 13 | |||
| – | PREDICTED: KDEL-tailed cysteine endopeptidase CEP2-like [Cicer arietinum] gi|502143938|ref|XP_004505522.1| | 16 | ||
| – | PREDICTED: cysteine proteinase RD21a-like [Fragaria vesca subsp]. vesca] gi|470110251|ref|XP_004291399.1| | 7 | ||
| – | Cysteine proteinase precursor [Glycine max] gi|351721126|ref|NP_001237199.1| | 27 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905116|dbj|BAF56430.1| | 13 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905116|dbj|BAF56430.1| | 27 | ||
| – | Papain-like cysteine proteinase-like protein 1 [Lotus japonicus] gi|33945877|emb|CAE45588.1| | 11 | ||
| – | PREDICTED: vignain-like [Glycine max] gi|356515086|ref|XP_003526232.1| | 13 | ||
| – | PREDICTED: cysteine proteinase RD21a-like isoform X1 [Cicer arietinum] gi|502120445|ref|XP_004496965.1| | 4 | ||
| – | PREDICTED: cysteine proteinase RD21a-like [Cicer arietinum] gi|502125689|ref|XP_004499026.1| | 20 | ||
| – | PREDICTED: cysteine proteinase RD21a-like [Glycine max] gi|356563584|ref|XP_003550041.1| | 17 | ||
| – | PREDICTED: oryzain alpha chain-like [Cicer arietinum] gi|502131381|ref|XP_004500967.1| | 32 | ||
| – | PREDICTED: cysteine proteinase RD19a-like [Glycine max] gi|356509908|ref|XP_003523684.1| | 27 | ||
| – | PREDICTED: xylem cysteine proteinase 2-like [Glycine max] gi|356517188|ref|XP_003527271.1| | 25 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905108|dbj|BAF56428.1| | 19 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905116|dbj|BAF56430.1| | 16 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905108|dbj|BAF56428.1| | 19 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905108|dbj|BAF56428.1| | 20 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905116|dbj|BAF56430.1| | 19 | ||
| – | PREDICTED: cathepsin B-like [Glycine max] gi|356505709|ref|XP_003521632.1| | 14 | ||
| – | CM0216.510.nc [Lotus japonicus] gi|164605519|dbj|BAF98585.1| | 26 | ||
| – | CM0216.500.nc [Lotus japonicus] gi|164605518|dbj|BAF98584.1| | 25 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|409190991|gb|AFV30165.1| | 26 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|144905104|dbj|BAF56427.1| | 26 | ||
| – | Cysteine proteinase [Lotus japonicus] gi|409190991|gb|AFV30165.1| | 8 | ||
| – | PREDICTED: vignain-like [Glycine max] gi|356563155|ref|XP_003549830.1| | 24 | ||
| – | PREDICTED: vignain-like [Glycine max] gi|356563155|ref|XP_003549830.1| | 27 | ||
| – | Cysteine protease [Medicago sativa] gi|94420703|gb|ABF18679.1| | 24 | ||
| – | PREDICTED: cysteine proteinase RD21a-like [Cicer arietinum] gi|502125689|ref|XP_004499026.1| | 30 | ||
| – | Cysteine proteinase precursor [Phaseolus vulgaris] gi|2511695|emb|CAB17077.1| | 9 | ||
| – | PREDICTED: cysteine proteinase RD21a-like isoform X1 [Cicer arietinum] gi|502120445|ref|XP_004496965.1| | 30 | ||
| – | PREDICTED: oryzain alpha chain-like [Cicer arietinum] gi|502131381|ref|XP_004500967.1| | 7 | ||
| – | Cysteine proteinase [Medicago truncatula] gi|357446993|ref|XP_003593772.1| | 26 | ||
| – | Cysteine proteinase [Medicago truncatula] gi|357446993|ref|XP_003593772.1| | 16 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: xylem cysteine proteinase 1-like [Cicer arietinum] gi|502078248|ref|XP_004485885.1| | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 2.33 |