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IPR014100

Source: InterPro

Description

IPR014100 is a GTP-binding protein Obg/CgtA.

<p>This entry describes a universal, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure.</p> <p>This is an essential GTPase which binds GTP, GDP and ppGpp with moderate affinity (with a twofold preference for GDP over GTP); shows high guanine nucleotide exchange rate constants for both nucleotides, and has a relatively low GTP hydrolysis rate. Deletion of the N terminus makes a protein that is non-functional in vivo but which retains nucleotide binding and GTPase activity. Required for cell cycle progression from G1 to S phase and for DNA replication [[cite:PUB00034535]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000287
Molecular function Magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
Subterm of
GO:0003924
Molecular function GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Subterm of
GO:0005525
Molecular function GTP binding Interacting selectively and non-covalently with GTP, guanosine triphosphate.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0057889.1
– PREDICTED: GTPase obg-like [Glycine max] gi|356551819|ref|XP_003544271.1|
Domains
19
Lj3g3v0397150.2
– PREDICTED: GTPase obg-like [Cicer arietinum] gi|502115632|ref|XP_004495251.1|
Domains
18
Lj5g3v0144410.1
– PREDICTED: GTPase obg-like [Glycine max] gi|356564323|ref|XP_003550404.1|
Domains
19
Lj6g3v1931780.1
– PREDICTED: GTPase obg-like isoform 1 [Glycine max] gi|356549083|ref|XP_003542927.1|
Domains
32
LotjaGi6g1v0307800.1
– GTPase obg; TAIR: AT5G18570.1 GTP1/OBG family protein; Swiss-Prot: sp|Q8L7L0|OBGC_ARATH GTP-binding protein OBGC, chloroplastic; TrEMBL-Plants: tr|A0A1J7H1V8|A0A1J7H1V8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0307800
Domains
37
LotjaGi6g1v0307800.2
– GTPase obg; TAIR: AT5G18570.1 GTP1/OBG family protein; Swiss-Prot: sp|Q8L7L0|OBGC_ARATH GTP-binding protein OBGC, chloroplastic; TrEMBL-Plants: tr|A0A1J7H1V8|A0A1J7H1V8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0307800
Domains
37

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67