Description

IPR031167 is a OBG-type guanine nucleotide-binding (G) domain.

<p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>Within the translation factor-related (TRAFAC) class of P-loop GTPases, the OBG family comprises a group of high-molecular mass GTPases conserved from bacteria to eukaryotes. The OBG family consists of [[cite:PUB00013952]]:</p> <ul> <li>Obg from bacteria and eukaryotes [[cite:PUB00027072], [cite:PUB00022779]].</li> <li>DRG from eukaryotes and archaea. DRG proteins may regulate fundamental cellular processes through RNA binding [[cite:PUB00074840]].</li> <li>Nog1 from eukaryotes and archaea. It is involved in the assembly of the large ribosomal subunit.</li> <li>Yyaf/YchF from bacteria and eukaryotes. It consists of a central G domain, flanked by a coiled-coil domain and a TGS (ThrRS, GTPase, SpoT) domain. Members of this subfamily bind and hydrolyse ATP more efficiently than GTP [[cite:PUB00016351], [cite:PUB00036769]].</li> <li>Ygr210 from archaea and fungi.</li> </ul> <p>The OBG-type G domain has a mononucleotide binding fold typical for the P-loop NTPases. A six-stranded mostly parallel β-sheet is flanked by α-helices on both sides. The OBG-type G domain contains five characteristic sequence motifs, termed G1-G5, involved in nucleotide binding and hydrolysis. The G1/Walker A motif (GXXXXGK(S/T)), also referred to as P-loop, helps to position the triphosphate moiety of the bound nucleotide. The G2 (X(T/S)X) and G3/Walker B (hhhDXXG) motifs are involved in the coordination of a Mg(2)+ ion that is required for nucleotide binding and hydrolysis. Specificity in nucleotide binding is conferred by the G4 motif, which has a (N/T)KXD signature in guanine nucleotide binding P-loop NTPases. The G5 motif ((T/G)(C/S)A) supports guanine base recognition [[cite:PUB00027072], [cite:PUB00022779], [cite:PUB00016351], [cite:PUB00036769]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 31

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: