Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR015633 is a E2F Family.
<p>The E2F family of transcription factors plays a crucial role in the control of cell cycle [[cite:PUB00096666], [cite:PUB00096667]] and action of tumour suppressor proteins. This family consists of eight members and is divided into activators (E2F1-3) and repressors (E2F4-8) depending on cellular context, target gene and cofactors [[cite:PUB00096666]]. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA-binding domain, a dimerisation domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumour suppressor protein association domain which is embedded within the transactivation domain [[cite:PUB00008097]]. Classical E2Fs (E2F1-6) contain one DNA-binding domain which form heterodimers with DP proteins; atypical family members, E2F7 and E2F8, possess two DNA-binding domains, form homodimers or heterodimers, thus regulating transcription in a DP-independent manner [[cite:PUB00096666]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: E2F transcription factor-like E2FE-like [Glycine max] gi|356516714|ref|XP_003527038.1| | 10 | ||
| – | PREDICTED: transcription factor E2FB-like [Glycine max] gi|356539215|ref|XP_003538095.1| | 6 | ||
| – | PREDICTED: transcription factor E2FB-like [Glycine max] gi|356539215|ref|XP_003538095.1| | 15 | ||
| – | PREDICTED: transcription factor E2FC-like [Glycine max] gi|356509584|ref|XP_003523527.1| | 8 | ||
| – | PREDICTED: transcription factor E2FC-like isoform X1 [Cicer arietinum] gi|502131315|ref|XP_004500945.1| | 6 | ||
| – | PREDICTED: transcription factor E2FB-like isoform X2 [Cicer arietinum] gi|502145866|ref|XP_004506214.1| | 15 | ||
| – | PREDICTED: transcription factor E2FB-like isoform X2 [Cicer arietinum] gi|502145866|ref|XP_004506214.1| | 15 | ||
| – | PREDICTED: E2F transcription factor-like E2FE-like isoform X1 [Cicer arietinum] gi|502152216|ref|XP_004508820.1| | 10 | ||
| – | PREDICTED: transcription factor E2FA-like [Cicer arietinum] gi|502122297|ref|XP_004497676.1| | 15 | ||
| – | E2F transcription factor; TAIR: AT3G48160.2 DP-E2F-like 1; Swiss-Prot: sp|Q8LSZ4|E2FE_ARATH E2F transcription factor-like E2FE; TrEMBL-Plants: tr|A0A0S3RGB4|A0A0S3RGB4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0184200 | 11 | ||
| – | Transcription factor; TAIR: AT1G47870.1 winged-helix DNA-binding transcription factor family protein; Swiss-Prot: sp|Q9FV70|E2FC_ARATH Transcription factor E2FC; TrEMBL-Plants: tr|A0A151TCJ9|A0A151TCJ9_CAJCA Transcription factor E2F4; Found in the gene: LotjaGi1g1v0428700 | 17 | ||
| – | Transcription factor; TAIR: AT5G22220.2 E2F transcription factor 1; Swiss-Prot: sp|Q9FV71|E2FB_ARATH Transcription factor E2FB; TrEMBL-Plants: tr|K7LQ43|K7LQ43_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0181200 | 17 | ||
| – | Transcription factor; TAIR: AT5G22220.2 E2F transcription factor 1; Swiss-Prot: sp|Q9FV71|E2FB_ARATH Transcription factor E2FB; TrEMBL-Plants: tr|K7LQ43|K7LQ43_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0472800 | 17 | ||
| – | E2F transcription factor; TAIR: AT3G48160.2 DP-E2F-like 1; Swiss-Prot: sp|Q8LSZ4|E2FE_ARATH E2F transcription factor-like E2FE; TrEMBL-Plants: tr|A0A151R8W6|A0A151R8W6_CAJCA Transcription factor E2F7; Found in the gene: LotjaGi4g1v0236800 | 11 | ||
| – | E2F transcription factor; TAIR: AT2G36010.3 E2F transcription factor 3; Swiss-Prot: sp|Q9FNY0|E2FA_ARATH Transcription factor E2FA; TrEMBL-Plants: tr|G7IE33|G7IE33_MEDTR E2F transcription factor; Found in the gene: LotjaGi5g1v0102600 | 4 | ||
| – | Transcription factor; TAIR: AT2G36010.1 E2F transcription factor 3; Swiss-Prot: sp|Q9FNY0|E2FA_ARATH Transcription factor E2FA; TrEMBL-Plants: tr|V7BL69|V7BL69_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0102600 | 17 | ||
| – | Transcription factor; TAIR: AT2G36010.1 E2F transcription factor 3; Swiss-Prot: sp|Q9FNY0|E2FA_ARATH Transcription factor E2FA; TrEMBL-Plants: tr|A0A0B2P0M7|A0A0B2P0M7_GLYSO Transcription factor E2FA; Found in the gene: LotjaGi5g1v0102600 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.88 |