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IPR022631 is a S-adenosylmethionine synthetase, conserved site.
<p>Two conserved site signatures are present in S-adenosylmethionine synthetase. The more N-terminal site represents a hexapeptide which is thought to be involved in ATP binding whilst the C-terminal conserved site is an almost perfectly conserved glycine-rich nonapeptide.</p> <P>S-adenosylmethionine synthetase (MAT, [ec:2.5.1.6]) is the enzyme that catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP [[cite:PUB00002572]]. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.</P> <P>In bacteria there is a single isoform of AdoMet synthetase (gene metK), there are two in budding yeast (genes SAM1 and SAM2) and in mammals while in plants there is generally a multigene family.</P> <P>The sequence of AdoMet synthetase is highly conserved throughout isozymes and species. The active sites of both the Escherichia coli and rat liver MAT reside between two subunits, with contributions from side chains of residues from both subunits, resulting in a dimer as the minimal catalytic entity. The side chains that contribute to the ligand binding sites are conserved between the two proteins. In the structures of complexes with the E. coli enzyme, the phosphate groups have the same positions in the (PPi plus Pi) complex and the (ADP plus Pi) complex and are located at the bottom of a deep cavity with the adenosyl group nearer the entrance [[cite:PUB00007175]].</P>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. | ||
Biological process | S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | RecName: Full=S-adenosylmethionine synthase 2; Short=AdoMet synthase 2; AltName: Full=Methionine adenosyltransferase 2; Short=MAT 2gi|38261499|gb|AAR15895.1| S-adenosyl-L-methionine synthetase [Nicotiana tabacum] gi|75292099|sp|Q6SYB9.1|METK2_TOBAC | 14 | ||
– | PREDICTED: S-adenosylmethionine synthase 2-like [Cucumis sativus] gi|449451048|ref|XP_004143274.1| | 12 | ||
– | 12 | |||
– | PREDICTED: S-adenosylmethionine synthase-like [Cicer arietinum] gi|502112841|ref|XP_004494460.1| | 18 | ||
– | RecName: Full=S-adenosylmethionine synthase 2; Short=AdoMet synthase 2; AltName: Full=Methionine adenosyltransferase 2; Short=MAT 2gi|38261499|gb|AAR15895.1| S-adenosyl-L-methionine synthetase [Nicotiana tabacum] gi|75292099|sp|Q6SYB9.1|METK2_TOBAC | 18 | ||
– | S-adenosylmethionine synthetase [Cajanus cajan] gi|374095594|gb|AEY85025.1| | 18 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|A0A0L9TX93|A0A0L9TX93_PHAAN S-adenosylmethionine synthase; Found in the gene: LotjaGi0g1v0002200 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|A0A0L9TX93|A0A0L9TX93_PHAAN S-adenosylmethionine synthase; Found in the gene: LotjaGi0g1v0002200 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|A0A0L9TX93|A0A0L9TX93_PHAAN S-adenosylmethionine synthase; Found in the gene: LotjaGi0g1v0002200 | 18 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q8W3Y4|METK_PHALU S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0118800 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 18 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT2G36880.1 methionine adenosyltransferase 3; Swiss-Prot: sp|Q6SYB9|METK2_TOBAC S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|I3SQ78|I3SQ78_LOTJA S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0688300 | 18 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|Q96552|METK2_CATRO S-adenosylmethionine synthase 2; TrEMBL-Plants: tr|V7D197|V7D197_PHAVU S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0750500 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT4G01850.1 S-adenosylmethionine synthetase 2; Swiss-Prot: sp|A4PU48|METK_MEDTR S-adenosylmethionine synthase; TrEMBL-Plants: tr|G7KUJ1|G7KUJ1_MEDTR S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0755600 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT4G01850.1 S-adenosylmethionine synthetase 2; Swiss-Prot: sp|A4PU48|METK_MEDTR S-adenosylmethionine synthase; TrEMBL-Plants: tr|G7KUJ1|G7KUJ1_MEDTR S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0755600 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT4G01850.1 S-adenosylmethionine synthetase 2; Swiss-Prot: sp|A4PU48|METK_MEDTR S-adenosylmethionine synthase; TrEMBL-Plants: tr|G7KUJ1|G7KUJ1_MEDTR S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0755600 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT4G01850.1 S-adenosylmethionine synthetase 2; Swiss-Prot: sp|A4PU48|METK_MEDTR S-adenosylmethionine synthase; TrEMBL-Plants: tr|G7KUJ1|G7KUJ1_MEDTR S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0755600 | 17 | ||
– | S-adenosylmethionine synthase; TAIR: AT4G01850.1 S-adenosylmethionine synthetase 2; Swiss-Prot: sp|A4PU48|METK_MEDTR S-adenosylmethionine synthase; TrEMBL-Plants: tr|G7KUJ1|G7KUJ1_MEDTR S-adenosylmethionine synthase; Found in the gene: LotjaGi1g1v0755600 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 18 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 26 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 25 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 25 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT1G02500.1 S-adenosylmethionine synthetase 1; Swiss-Prot: sp|P43280|METK1_SOLLC S-adenosylmethionine synthase 1; TrEMBL-Plants: tr|A0A097GX09|A0A097GX09_ROBPS S-adenosylmethionine synthase; Found in the gene: LotjaGi4g1v0312800 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 | ||
– | S-adenosylmethionine synthase; TAIR: AT3G17390.1 S-adenosylmethionine synthetase family protein; Swiss-Prot: sp|A4ULF8|METK_MEDSF S-adenosylmethionine synthase; TrEMBL-Plants: tr|A0A1J7GAD4|A0A1J7GAD4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0216300 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd18079 | CDD | 1 | 2.38 |