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IPR039189 is a CTD phosphatase Fcp1.
<p>This entry represents Fcp1 and its homologues, including CTDP1 from humans and CPL1/2/3/4/5 from Arabidopsis. They are carboxy-terminal domain (CTD) phosphatases. CPL1 has been shown to interact with two NMD (nonsense-mediated decay) factors, eIF4AIII and UPF3, and is involved in the dephosphorylation of eIF4AIII [[cite:PUB00089263]]. CPL4 functions as a pol II CTD phosphatase and has been shown to dephosphorylate both Ser2- and Ser5-PO(4) of CTD in vitro [[cite:PUB00089264]]. Budding yeast Fcp1 has been shown to dephosphorylate RNA polymerase (RNAP) II subunit, and this interaction is modulated by the Pin1 protein [[cite:PUB00089265]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA polymerase II CTD heptapeptide repeat phosphatase activity | Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate. | ||
| Biological process | Dephosphorylation of RNA polymerase II C-terminal domain | The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA polymerase II C-terminal domain phosphatase-like 2; TAIR: AT5G01270.1 carboxyl-terminal domain (ctd) phosphatase-like 2; Swiss-Prot: sp|Q5YDB5|CPL2_ARATH RNA polymerase II C-terminal domain phosphatase-like 2; TrEMBL-Plants: tr|K7L1T3|K7L1T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0439500 | 18 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT2G33540.1 C-terminal domain phosphatase-like 3; Swiss-Prot: sp|Q8LL04|CPL3_ARATH RNA polymerase II C-terminal domain phosphatase-like 3; TrEMBL-Plants: tr|I1KWR8|I1KWR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529200 | 24 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A072UR90|A0A072UR90_MEDTR Carboxy-terminal domain phosphatase-like protein; Found in the gene: LotjaGi1g1v0661000 | 14 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like 1; TAIR: AT4G21670.1 C-terminal domain phosphatase-like 1; Swiss-Prot: sp|Q5YDB6|CPL1_ARATH RNA polymerase II C-terminal domain phosphatase-like 1; TrEMBL-Plants: tr|A0A0S3QZI5|A0A0S3QZI5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0054200 | 18 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.3 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A151SFP9|A0A151SFP9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0286500 | 14 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|V7BX02|V7BX02_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100 | 23 | ||
| – | RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A0L9TRV4|A0A0L9TRV4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd17729 | CDD | 1 | 14.29 |