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IPR039192 is a Glycogen synthase kinase 3, catalytic domain.
<p>Glycogen synthase kinase 3 (GSK3) is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress [[cite:PUB00089271], [cite:PUB00089281]]. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress [[cite:PUB00089269]]. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly [[cite:PUB00089270]].</p> <p>Mammals have two isoforms of GSK3, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini [[cite:PUB00089277]]. They are both involved in axon formation and in Wnt signaling [[cite:PUB00089278], [cite:PUB00089279]]. They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry [[cite:PUB00089280]]. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others [[cite:PUB00089272], [cite:PUB00089276], [cite:PUB00089273]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Protein kinase; TAIR: AT4G00720.1 shaggy-like protein kinase 32; Swiss-Prot: sp|Q96287|KSG8_ARATH Shaggy-related protein kinase theta; TrEMBL-Plants: tr|I1N3I7|I1N3I7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0467900 | 18 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P43288|KSG1_ARATH Shaggy-related protein kinase alpha; TrEMBL-Plants: tr|A0A1J7HK82|A0A1J7HK82_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0749900 | 16 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51137|MSK1_MEDSA Glycogen synthase kinase-3 homolog MsK-1; TrEMBL-Plants: tr|A0A1J7FSZ6|A0A1J7FSZ6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0749900 | 16 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P43288|KSG1_ARATH Shaggy-related protein kinase alpha; TrEMBL-Plants: tr|A0A1J7HK82|A0A1J7HK82_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0749900 | 16 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|G7KTQ8|G7KTQ8_MEDTR Glycogen synthase kinase; Found in the gene: LotjaGi1g1v0756100 | 16 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|G7KTQ8|G7KTQ8_MEDTR Glycogen synthase kinase; Found in the gene: LotjaGi1g1v0756100 | 16 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|G7KTQ8|G7KTQ8_MEDTR Glycogen synthase kinase; Found in the gene: LotjaGi1g1v0756100 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 17 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|G7IM77|G7IM77_MEDTR Shaggy-like kinase dzeta; Found in the gene: LotjaGi3g1v0239700 | 16 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|A0A0L9V5W8|A0A0L9V5W8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0252700 | 17 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|A0A0S3SB02|A0A0S3SB02_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0252700 | 17 | ||
– | Kinase family protein; TAIR: AT2G30980.1 SHAGGY-related protein kinase dZeta; Swiss-Prot: sp|Q39010|KSG6_ARATH Shaggy-related protein kinase zeta; TrEMBL-Plants: tr|I1LSH6|I1LSH6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0252700 | 16 | ||
– | Protein kinase; TAIR: AT1G06390.1 GSK3/SHAGGY-like protein kinase 1; Swiss-Prot: sp|Q39012|KSG9_ARATH Shaggy-related protein kinase iota; TrEMBL-Plants: tr|A0A067FB69|A0A067FB69_CITSI Uncharacterized protein; Found in the gene: LotjaGi3g1v0252700 | 16 | ||
– | Kinase family protein; TAIR: AT4G00720.1 shaggy-like protein kinase 32; Swiss-Prot: sp|Q96287|KSG8_ARATH Shaggy-related protein kinase theta; TrEMBL-Plants: tr|Q53VM1|Q53VM1_LOTJA Ser/Thr protein kinase; Found in the gene: LotjaGi3g1v0377100 | 18 | ||
– | Protein kinase; TAIR: AT3G05840.1 Protein kinase superfamily protein; Swiss-Prot: sp|P51137|MSK1_MEDSA Glycogen synthase kinase-3 homolog MsK-1; TrEMBL-Plants: tr|Q53VM0|Q53VM0_LOTJA Ser/Thr protein kinase; Found in the gene: LotjaGi5g1v0233000 | 17 | ||
– | Protein kinase; TAIR: AT3G05840.1 Protein kinase superfamily protein; Swiss-Prot: sp|P51137|MSK1_MEDSA Glycogen synthase kinase-3 homolog MsK-1; TrEMBL-Plants: tr|Q53VM0|Q53VM0_LOTJA Ser/Thr protein kinase; Found in the gene: LotjaGi5g1v0233000 | 17 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|A0A0B2NY95|A0A0B2NY95_GLYSO Glycogen synthase kinase-3 like MsK-3; Found in the gene: LotjaGi5g1v0241000 | 17 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|A0A0B2NY95|A0A0B2NY95_GLYSO Glycogen synthase kinase-3 like MsK-3; Found in the gene: LotjaGi5g1v0241000 | 17 | ||
– | Protein kinase; TAIR: AT5G26751.1 shaggy-related kinase 11; Swiss-Prot: sp|P51139|MSK3_MEDSA Glycogen synthase kinase-3 homolog MsK-3; TrEMBL-Plants: tr|A0A0R0L0N7|A0A0R0L0N7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0241000 | 17 | ||
– | Kinase family protein; TAIR: AT4G18710.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q39011|KSG7_ARATH Shaggy-related protein kinase eta; TrEMBL-Plants: tr|I3T330|I3T330_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0321300 | 16 | ||
– | Kinase family protein; TAIR: AT4G18710.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q39011|KSG7_ARATH Shaggy-related protein kinase eta; TrEMBL-Plants: tr|I3T330|I3T330_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0321300 | 16 | ||
– | Kinase family protein; TAIR: AT4G18710.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q39011|KSG7_ARATH Shaggy-related protein kinase eta; TrEMBL-Plants: tr|I3T330|I3T330_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0321300 | 16 | ||
– | Kinase family protein; TAIR: AT1G06390.1 GSK3/SHAGGY-like protein kinase 1; Swiss-Prot: sp|Q39011|KSG7_ARATH Shaggy-related protein kinase eta; TrEMBL-Plants: tr|I3T330|I3T330_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0321300 | 16 | ||
– | Kinase family protein; TAIR: AT4G18710.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q39011|KSG7_ARATH Shaggy-related protein kinase eta; TrEMBL-Plants: tr|I3T330|I3T330_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0321300 | 16 | ||
– | Protein kinase; TAIR: AT1G09840.1 shaggy-like protein kinase 41; Swiss-Prot: sp|Q39019|KSG10_ARATH Shaggy-related protein kinase kappa; TrEMBL-Plants: tr|V4T0F2|V4T0F2_9ROSI Uncharacterized protein; Found in the gene: LotjaGi6g1v0364700 | 17 | ||
– | Protein kinase; TAIR: AT1G09840.1 shaggy-like protein kinase 41; Swiss-Prot: sp|Q39019|KSG10_ARATH Shaggy-related protein kinase kappa; TrEMBL-Plants: tr|Q1SL21|Q1SL21_MEDTR Protein kinase; Found in the gene: LotjaGi6g1v0364700 | 14 | ||
– | Protein kinase; TAIR: AT1G09840.1 shaggy-like protein kinase 41; Swiss-Prot: sp|Q39019|KSG10_ARATH Shaggy-related protein kinase kappa; TrEMBL-Plants: tr|Q1SL21|Q1SL21_MEDTR Protein kinase; Found in the gene: LotjaGi6g1v0364700 | 14 | ||
– | Protein kinase; TAIR: AT1G09840.1 shaggy-like protein kinase 41; Swiss-Prot: sp|Q39019|KSG10_ARATH Shaggy-related protein kinase kappa; TrEMBL-Plants: tr|I1LTB4|I1LTB4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0364700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd14137 | CDD | 1 | 3.13 |