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IPR000116 is a High mobility group protein HMGA.
<p>This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [[cite:PUB00074434]].</p> <p>The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [[cite:PUB00074432]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. | ||
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | HMG-Y-related protein A [Medicago truncatula] gi|357460891|ref|XP_003600727.1| | 17 | ||
| – | AT-hook protein 1 [Zea mays] gi|226532898|ref|NP_001149717.1| | 16 | ||
| – | High mobility group protein [Canavalia gladiata] gi|1181589|dbj|BAA11766.1| | 17 | ||
| – | HMGI/Y [Pisum sativum] gi|899367|emb|CAA61747.1| | 17 | ||
| – | HMG-Y-related protein A; TAIR: AT1G14900.1 high mobility group A; Swiss-Prot: sp|Q00423|HMGYA_SOYBN HMG-Y-related protein A; TrEMBL-Plants: tr|A0A1J7HLR9|A0A1J7HLR9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0092300 | 18 | ||
| – | AT hook motif DNA-binding family protein; TAIR: AT2G33620.1 AT hook motif DNA-binding family protein; Swiss-Prot: sp|O22812|AHL10_ARATH AT-hook motif nuclear-localized protein 10; TrEMBL-Plants: tr|V7AUS6|V7AUS6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0569400 | 19 | ||
| – | Histone H1; TAIR: AT1G48620.1 high mobility group A5; Swiss-Prot: sp|Q9FYS5|HMGYA_MAIZE HMG-Y-related protein A; TrEMBL-Plants: tr|V7CTB3|V7CTB3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0198500 | 17 | ||
| – | Transcription factor jumonji domain-containing protein, putative isoform 2; TAIR: AT3G18035.2 winged-helix DNA-binding transcription factor family protein; Swiss-Prot: sp|P52927|HMGA2_MOUSE High mobility group protein HMGI-C; TrEMBL-Plants: tr|A0A061G1U9|A0A061G1U9_THECC Transcription factor jumonji domain-containing protein, putative isoform 1; Found in the gene: LotjaGi3g1v0261700_LC | 2 | ||
| – | HMG-Y-related protein A; TAIR: AT1G14900.1 high mobility group A; Swiss-Prot: sp|Q00423|HMGYA_SOYBN HMG-Y-related protein A; TrEMBL-Plants: tr|A0A1J7HLR9|A0A1J7HLR9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0056500 | 18 | ||
| – | HMG-Y-related A; TAIR: AT1G14900.1 high mobility group A; Swiss-Prot: sp|Q00423|HMGYA_SOYBN HMG-Y-related protein A; TrEMBL-Plants: tr|G7J9E3|G7J9E3_MEDTR Linker histone H1 and h5 family protein; Found in the gene: LotjaGi6g1v0056600 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |