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IPR001844

Description

IPR001844 is a Chaperonin Cpn60/GroEL.

<p>The assembly of proteins has been thought to be the sole result of properties inherent in the primary sequence of polypeptides themselves. In some cases, however, structural information from other protein molecules is required for correct folding and subsequent assembly into oligomers [[cite:PUB00004022]]. These `helper' molecules are referred to as molecular chaperones, a subfamily of which are the chaperonins [[cite:PUB00004550]]. They are required for normal cell growth (as demonstrated by the fact that no temperature sensitive mutants for the chaperonin genes can be found in the temperature range 20 to 43 degrees centigrade [[cite:PUB00004022]]), and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions [[cite:PUB00004550]]. This entry represents the 60kDa chaperonin (Cpn60), its bacterial homologue groEL and RuBisCO subunit-binding protein [[cite:PUB00099589]]), which are mainly present in bacteria and eukaryots.</p> <p>The 60kDa form of chaperonin is the immunodominant antigen of patients with Legionnaire's disease [[cite:PUB00001725]], and is thought to play a role in the protection of the Legionella spp. bacteria from oxygen radicals within macrophages. This hypothesis is based on the finding that the cpn60 gene is upregulated in response to hydrogen peroxide, a source of oxygen radicals. Cpn60 has also been found to display strong antigenicity in many bacterial species [[cite:PUB00000632]], and has the potential for inducing immune protection against unrelated bacterial infections. The RuBisCO subunit binding protein (which has been implicated in the assembly of RuBisCO) and cpn60 have been found to be evolutionary homologues, the RuBisCO subunit binding protein having the C-terminal Gly-Gly-Met repeat found in all bacterial cpn60 sequences. Although the precise function of this repeat is unknown, it is thought to be important as it is also found in 70kDa heat-shock proteins [[cite:PUB00001725]]. The crystal structure of Escherichia coli GroEL has been resolved to 2.8A [[cite:PUB00004190]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

Associated Lotus transcripts 32

Transcript Name Description Predicted domains Domain count
PREDICTED: chaperonin CPN60-2, mitochondrial-like [Cicer arietinum] gi|502118056|ref|XP_004496079.1| 15
PREDICTED: chaperonin CPN60-2, mitochondrial-like [Cicer arietinum] gi|502118058|ref|XP_004496080.1| 10
10
PREDICTED: ruBisCO large subunit-binding protein subunit beta, chloroplastic-like [Glycine max] gi|356495746|ref|XP_003516734.1| 9
PREDICTED: ruBisCO large subunit-binding protein subunit beta, chloroplastic-like [Glycine max] gi|356502680|ref|XP_003520145.1| 19
PREDICTED: ruBisCO large subunit-binding protein subunit beta, chloroplastic-like [Glycine max] gi|356495746|ref|XP_003516734.1| 15
PREDICTED: ruBisCO large subunit-binding protein subunit beta, chloroplastic-like [Glycine max] gi|356502680|ref|XP_003520145.1| 17
RecName: Full=RuBisCO large subunit-binding protein subunit beta, chloroplastic; AltName: Full=60 kDa chaperonin subunit beta; AltName: Full=CPN-60 beta; Flags: Precursorgi|806808|gb|AAA66365.1| chaperonin precursor [Pisum sativum] gi|2506277|sp|P08927.2|RUBB_PEA 20
PREDICTED: chaperonin CPN60-like 2, mitochondrial-like [Cicer arietinum] gi|502156248|ref|XP_004510380.1| 11
PREDICTED: chaperonin CPN60-like 2, mitochondrial-like [Glycine max] gi|356526013|ref|XP_003531614.1| 16
PREDICTED: ruBisCO large subunit-binding protein subunit alpha, chloroplastic-like [Cicer arietinum] gi|502145480|ref|XP_004506047.1| 19
RuBisCO large subunit-binding protein subunit alpha [Medicago truncatula] gi|357475213|ref|XP_003607892.1| 15
Chaperonin CPN60-like protein [Medicago truncatula] gi|357442731|ref|XP_003591643.1| 19
60 kDa chaperonin; TAIR: AT1G26230.2 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q9C667|CPNB4_ARATH Chaperonin 60 subunit beta 4, chloroplastic; TrEMBL-Plants: tr|A0A151R5F8|A0A151R5F8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0287400 19
60 kDa chaperonin; TAIR: AT1G26230.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q9C667|CPNB4_ARATH Chaperonin 60 subunit beta 4, chloroplastic; TrEMBL-Plants: tr|A0A151R5F8|A0A151R5F8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0287400 21
60 kDa chaperonin; TAIR: AT1G26230.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q9C667|CPNB4_ARATH Chaperonin 60 subunit beta 4, chloroplastic; TrEMBL-Plants: tr|A0A151R5F8|A0A151R5F8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0287400 19
60 kDa chaperonin; TAIR: AT1G55490.1 chaperonin 60 beta; Swiss-Prot: sp|P08927|RUBB_PEA RuBisCO large subunit-binding protein subunit beta, chloroplastic; TrEMBL-Plants: tr|A0A1J7FWW4|A0A1J7FWW4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0145800 22
60 kDa chaperonin; TAIR: AT1G55490.1 chaperonin 60 beta; Swiss-Prot: sp|P08927|RUBB_PEA RuBisCO large subunit-binding protein subunit beta, chloroplastic; TrEMBL-Plants: tr|A0A1J7FWW4|A0A1J7FWW4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0145800 22
Chaperonin-60 kDa protein; TAIR: AT3G13860.1 heat shock protein 60-3A; Swiss-Prot: sp|Q93ZM7|CH60C_ARATH Chaperonin CPN60-like 2, mitochondrial; TrEMBL-Plants: tr|A0A1J7HWB3|A0A1J7HWB3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0425000 22
60 kDa chaperonin; TAIR: AT2G28000.1 chaperonin-60alpha; Swiss-Prot: sp|P08926|RUBA_PEA RuBisCO large subunit-binding protein subunit alpha, chloroplastic; TrEMBL-Plants: tr|I3SYP8|I3SYP8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0488200 21
60 kDa chaperonin; TAIR: AT5G18820.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q56XV8|CPNA2_ARATH Chaperonin 60 subunit alpha 2, chloroplastic; TrEMBL-Plants: tr|I1KM81|I1KM81_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0083300 17
60 kDa chaperonin; TAIR: AT5G18820.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q56XV8|CPNA2_ARATH Chaperonin 60 subunit alpha 2, chloroplastic; TrEMBL-Plants: tr|G7JJX9|G7JJX9_MEDTR TCP-1/cpn60 chaperonin family protein; Found in the gene: LotjaGi4g1v0083300 16
60 kDa chaperonin; TAIR: AT5G18820.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q56XV8|CPNA2_ARATH Chaperonin 60 subunit alpha 2, chloroplastic; TrEMBL-Plants: tr|G7JJX9|G7JJX9_MEDTR TCP-1/cpn60 chaperonin family protein; Found in the gene: LotjaGi4g1v0083300 16
60 kDa chaperonin; TAIR: AT5G18820.1 TCP-1/cpn60 chaperonin family protein; Swiss-Prot: sp|Q56XV8|CPNA2_ARATH Chaperonin 60 subunit alpha 2, chloroplastic; TrEMBL-Plants: tr|G7JJX9|G7JJX9_MEDTR TCP-1/cpn60 chaperonin family protein; Found in the gene: LotjaGi4g1v0083300 17
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|A0A0B2NVB9|A0A0B2NVB9_GLYSO Chaperonin CPN60-2, mitochondrial; Found in the gene: LotjaGi5g1v0258100 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0258100 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0258100 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0258100 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0262500 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0262500 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0262500 21
60 kDa chaperonin; TAIR: AT3G23990.1 heat shock protein 60; Swiss-Prot: sp|Q05046|CH62_CUCMA Chaperonin CPN60-2, mitochondrial; TrEMBL-Plants: tr|Q1RSH3|Q1RSH3_MEDTR GroEL-like chaperone, ATPase; Found in the gene: LotjaGi5g1v0262500 21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03344 CDD 1 3.13