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IPR004541 is a Translation elongation factor EFTu/EF1A, bacterial/organelle.
<p>Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [[cite:PUB00033953], [cite:PUB00033952], [cite:PUB00033951]]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.</p> <p>EF-Tu (also known as EF-1alpha or EF1A) is a G-protein. It forms a ternary complex of EF-Tu (EF1A)-GTP-aminoacyltRNA. The binding of aminoacyl-tRNA stimulates GTP hydrolysis by EF-Tu (EF1A), causing a conformational change in EF-Tu (EF1A) that causes EF-Tu (EF1A)-GDP to detach from the ribosome, leaving the aminoacyl-tRNA attached at the A-site. Only the cognate aminoacyl-tRNA can induce the required conformational change in EF-Tu (EF1A) through its tight anticodon-codon binding [[cite:PUB00033960], [cite:PUB00033961]]. EF-Tu (EF1A)-GDP is returned to its active state, EF-Tu (EF1A)-GTP, through the action of another elongation factor, EF1B (also known as EF-Ts or EF-1beta/gamma/delta).</p> <p>This entry represents EF1A (or EF-Tu) proteins found primarily in bacteria, mitochondria and chloroplasts. Eukaryotic and archaeal EF1A ([interpro:IPR004539]) are excluded from this entry. When bound to GTP, EF-Tu can form a complex with any (correctly) aminoacylated tRNA except those for initiation and for selenocysteine, in which case EF-Tu is replaced by other factors [[cite:PUB00027704]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. | ||
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. | ||
| Biological process | Translational elongation | The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: elongation factor Tu, chloroplastic-like [Glycine max] gi|356513781|ref|XP_003525588.1| | 30 | ||
| – | PREDICTED: elongation factor Tu, mitochondrial-like [Glycine max] gi|356572160|ref|XP_003554238.1| | 29 | ||
| – | PREDICTED: elongation factor Tu, chloroplastic-like [Glycine max] gi|356513781|ref|XP_003525588.1| | 25 | ||
| – | Elongation factor Tu; TAIR: AT4G20360.1 RAB GTPase homolog E1B; Swiss-Prot: sp|P46280|EFTU2_SOYBN Elongation factor Tu, chloroplastic; TrEMBL-Plants: tr|K7KMT9|K7KMT9_SOYBN Elongation factor Tu; Found in the gene: LotjaGi1g1v0198100 | 31 | ||
| – | Elongation factor Tu; TAIR: AT4G02930.1 GTP binding Elongation factor Tu family protein; Swiss-Prot: sp|Q9ZT91|EFTM_ARATH Elongation factor Tu, mitochondrial; TrEMBL-Plants: tr|V7CYM1|V7CYM1_PHAVU Elongation factor Tu; Found in the gene: LotjaGi1g1v0730600 | 30 | ||
| – | Elongation factor Tu; TAIR: AT4G20360.1 RAB GTPase homolog E1B; Swiss-Prot: sp|P46280|EFTU2_SOYBN Elongation factor Tu, chloroplastic; TrEMBL-Plants: tr|K7KMT9|K7KMT9_SOYBN Elongation factor Tu; Found in the gene: LotjaGi4g1v0228100 | 32 | ||
| – | Elongation factor Tu; TAIR: AT4G02930.1 GTP binding Elongation factor Tu family protein; Swiss-Prot: sp|Q9ZT91|EFTM_ARATH Elongation factor Tu, mitochondrial; TrEMBL-Plants: tr|A0A151U0N5|A0A151U0N5_CAJCA Elongation factor Tu; Found in the gene: LotjaGi6g1v0300500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03707 | CDD | 1 | 14.29 |