Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR008936

Source: InterPro

Description

IPR008936 is a Rho GTPase activation protein.

<p>Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyse the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [[cite:PUB00010623]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0007165
Biological process Signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Subterm of
Part of

Associated Lotus transcripts 44

Transcript Name Description Predicted domains Domain count
Lj0g3v0002119.1
– PREDICTED: rho GTPase-activating protein gacA-like isoform X2 [Cicer arietinum] gi|502145805|ref|XP_004506186.1|
Domains
10
Lj0g3v0002119.2
– PREDICTED: rho GTPase-activating protein gacA-like isoform X2 [Cicer arietinum] gi|502145805|ref|XP_004506186.1|
Domains
13
Lj0g3v0002119.3
– PREDICTED: rho GTPase-activating protein gacA-like isoform X2 [Cicer arietinum] gi|502145805|ref|XP_004506186.1|
Domains
10
Lj0g3v0174019.1
– Rac GTPase activating protein 3 [Lotus japonicus] gi|3695063|gb|AAC62626.1|
Domains
13
Lj0g3v0174029.1
– Rac GTPase activating protein 3 [Lotus japonicus] gi|3695063|gb|AAC62626.1|
Domains
14
Lj0g3v0334489.1
– Rac GTPase activating protein, partial [Medicago truncatula] gi|357514407|ref|XP_003627492.1|
Domains
17
Lj1g3v1582540.1
– PREDICTED: uro-adherence factor A-like isoform X1 [Cicer arietinum] gi|502133026|ref|XP_004501625.1|
Domains
10
Lj1g3v1582550.1
– Rho GTPase-activating protein [Medicago truncatula] gi|357465311|ref|XP_003602937.1|
Domains
15
Lj1g3v4717450.1
– Rac GTPase activating protein 1 [Lotus japonicus] gi|3695059|gb|AAC62624.1|
Domains
17
Lj1g3v4717460.1
–
Domains
17
Lj1g3v4764220.1
– Rac GTPase activating protein 3 [Lotus japonicus] gi|3695063|gb|AAC62626.1|
Domains
16
Lj1g3v4764230.1
– Rac GTPase activating protein 3 [Lotus japonicus] gi|3695063|gb|AAC62626.1|
Domains
16
Lj1g3v5060420.1
– Rac GTPase activating protein 2 [Lotus japonicus] gi|3695061|gb|AAC62625.1|
Domains
16
Lj1g3v5060430.1
– Rac GTPase activating protein 2 [Lotus japonicus] gi|3695061|gb|AAC62625.1|
Domains
11
Lj2g3v3022930.1
– PREDICTED: platelet binding protein GspB-like isoform X1 [Cicer arietinum] gi|502098400|ref|XP_004491226.1|
Domains
23
Lj2g3v3022930.2
– PREDICTED: platelet binding protein GspB-like isoform X2 [Cicer arietinum] gi|502098404|ref|XP_004491227.1|
Domains
22
Lj3g3v1182350.1
– PREDICTED: rho GTPase-activating protein 24-like [Cicer arietinum] gi|502083538|ref|XP_004487490.1|
Domains
17
Lj3g3v1182350.2
– PREDICTED: rho GTPase-activating protein 24-like [Cicer arietinum] gi|502083538|ref|XP_004487490.1|
Domains
17
Lj3g3v2993420.1
– PREDICTED: rho GTPase-activating protein 24-like [Cicer arietinum] gi|502083538|ref|XP_004487490.1|
Domains
17
Lj5g3v1681410.1
– PREDICTED: rho GTPase-activating protein 19-like [Cicer arietinum] gi|502117904|ref|XP_004496003.1|
Domains
15
LotjaGi1g1v0050600.1
– Rho GTPase-activating protein; TAIR: AT5G19390.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|Q8RWQ4|RGAP7_ARATH Rho GTPase-activating protein 7; TrEMBL-Plants: tr|A0A1J7HR12|A0A1J7HR12_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0050600
Domains
22
LotjaGi1g1v0050600.2
– Rho GTPase-activating protein; TAIR: AT5G19390.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|Q8RWQ4|RGAP7_ARATH Rho GTPase-activating protein 7; TrEMBL-Plants: tr|A0A1J7HR12|A0A1J7HR12_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0050600
Domains
14
LotjaGi1g1v0050600.3
– Rho GTPase-activating protein; TAIR: AT5G19390.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|Q8RWQ4|RGAP7_ARATH Rho GTPase-activating protein 7; TrEMBL-Plants: tr|A0A1J7HR12|A0A1J7HR12_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0050600
Domains
14
LotjaGi1g1v0050600.4
– Rho GTPase-activating protein; TAIR: AT5G19390.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|Q8RWQ4|RGAP7_ARATH Rho GTPase-activating protein 7; TrEMBL-Plants: tr|A0A1J7HR12|A0A1J7HR12_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0050600
Domains
14
LotjaGi1g1v0050600.5
– Rho GTPase-activating protein; TAIR: AT5G19390.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|Q8RWQ4|RGAP7_ARATH Rho GTPase-activating protein 7; TrEMBL-Plants: tr|A0A1J7HR12|A0A1J7HR12_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0050600
Domains
14
LotjaGi1g1v0348300.1
– Rho GTPase-activating protein; TAIR: AT4G24580.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|F4JQZ3|REN1_ARATH Rho GTPase-activating protein REN1; TrEMBL-Plants: tr|K7KU55|K7KU55_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0348300
Domains
22
LotjaGi1g1v0348300.2
– Rho GTPase-activating protein; TAIR: AT4G24580.1 Rho GTPase activation protein (RhoGAP) with PH domain-containing protein; Swiss-Prot: sp|F4JQZ3|REN1_ARATH Rho GTPase-activating protein REN1; TrEMBL-Plants: tr|K7KU56|K7KU56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0348300
Domains
22
LotjaGi1g1v0394400_LC.1
– Rho GTPase-activating protein; TAIR: AT3G11490.1 rac GTPase activating protein; Swiss-Prot: sp|Q9CAX8|RGAP4_ARATH Rho GTPase-activating protein 4; TrEMBL-Plants: tr|W9QUM2|W9QUM2_9ROSA Rho GTPase-activating protein gacA; Found in the gene: LotjaGi1g1v0394400_LC
Domains
9
LotjaGi1g1v0394400_LC.2
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|W9QUM2|W9QUM2_9ROSA Rho GTPase-activating protein gacA; Found in the gene: LotjaGi1g1v0394400_LC
Domains
9
LotjaGi1g1v0394400_LC.3
– Rho GTPase-activating protein; TAIR: AT3G11490.1 rac GTPase activating protein; Swiss-Prot: sp|Q9CAX8|RGAP4_ARATH Rho GTPase-activating protein 4; TrEMBL-Plants: tr|W9QUM2|W9QUM2_9ROSA Rho GTPase-activating protein gacA; Found in the gene: LotjaGi1g1v0394400_LC
Domains
9
LotjaGi1g1v0675100.1
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|O82458|O82458_LOTJA Rac GTPase activating protein 1; Found in the gene: LotjaGi1g1v0675100
Domains
18
LotjaGi1g1v0743900.1
– Rho GTPase-activating protein; TAIR: AT4G03100.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|F4JI46|RGAP2_ARATH Rho GTPase-activating protein 2; TrEMBL-Plants: tr|O82460|O82460_LOTJA Rac GTPase activating protein 3; Found in the gene: LotjaGi1g1v0743900
Domains
17
LotjaGi1g1v0795800.1
– Rho GTPase-activating protein; TAIR: AT2G46710.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q8GYY5|RGAP3_ARATH Rho GTPase-activating protein 3; TrEMBL-Plants: tr|O82459|O82459_LOTJA Rac GTPase activating protein 2; Found in the gene: LotjaGi1g1v0795800
Domains
17
LotjaGi3g1v0055700.1
– Rho gtpase-activating protein; TAIR: AT5G61530.1 small G protein family protein / RhoGAP family protein; Swiss-Prot: sp|Q3E875|RGAPX_ARATH Uncharacterized Rho GTPase-activating protein At5g61530; TrEMBL-Plants: tr|I1LVH2|I1LVH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055700
Domains
9
LotjaGi3g1v0055700.2
– Rho gtpase-activating protein; TAIR: AT5G61530.1 small G protein family protein / RhoGAP family protein; Swiss-Prot: sp|Q3E875|RGAPX_ARATH Uncharacterized Rho GTPase-activating protein At5g61530; TrEMBL-Plants: tr|I1LVH2|I1LVH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055700
Domains
9
LotjaGi3g1v0055700.3
– Rho gtpase-activating protein; TAIR: AT5G61530.1 small G protein family protein / RhoGAP family protein; Swiss-Prot: sp|Q3E875|RGAPX_ARATH Uncharacterized Rho GTPase-activating protein At5g61530; TrEMBL-Plants: tr|I1LVH2|I1LVH2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055700
Domains
9
LotjaGi3g1v0177500.1
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|G7ITU3|G7ITU3_MEDTR PAK-box/P21-Rho-binding domain Rho GTPase activating protein; Found in the gene: LotjaGi3g1v0177500
Domains
17
LotjaGi3g1v0177500.2
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|G7ITU3|G7ITU3_MEDTR PAK-box/P21-Rho-binding domain Rho GTPase activating protein; Found in the gene: LotjaGi3g1v0177500
Domains
11
LotjaGi3g1v0401300.1
– Rho GTPase-activating protein; TAIR: AT2G46710.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q8GYY5|RGAP3_ARATH Rho GTPase-activating protein 3; TrEMBL-Plants: tr|G7L9Z1|G7L9Z1_MEDTR Rac GTPase activating protein; Found in the gene: LotjaGi3g1v0401300
Domains
18
LotjaGi3g1v0476500.1
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|A0A0L9V664|A0A0L9V664_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0476500
Domains
19
LotjaGi4g1v0178600_LC.1
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|W9QUM2|W9QUM2_9ROSA Rho GTPase-activating protein gacA; Found in the gene: LotjaGi4g1v0178600_LC
Domains
9
LotjaGi4g1v0178600_LC.2
– Rho GTPase-activating protein; TAIR: AT5G22400.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|Q9FMR1|RGAP1_ARATH Rho GTPase-activating protein 1; TrEMBL-Plants: tr|W9QUM2|W9QUM2_9ROSA Rho GTPase-activating protein gacA; Found in the gene: LotjaGi4g1v0178600_LC
Domains
9
LotjaGi5g1v0261200.1
– Rho GTPase-activating protein; TAIR: AT4G03100.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|F4JI46|RGAP2_ARATH Rho GTPase-activating protein 2; TrEMBL-Plants: tr|A0A0L9TWU4|A0A0L9TWU4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0261200
Domains
17
LotjaGi5g1v0261200.2
– Rho GTPase-activating protein; TAIR: AT4G03100.1 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein; Swiss-Prot: sp|F4JI46|RGAP2_ARATH Rho GTPase-activating protein 2; TrEMBL-Plants: tr|K7K8H7|K7K8H7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0261200
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.27