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IPR013049 is a Spo11/DNA topoisomerase VI, subunit A, N-terminal.
<p>This entry represents the N-terminal domain found in Spo11, a meiotic recombination protein found in eukaryotes, and in subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [[cite:PUB00007202], [cite:PUB00020804]]. These two types of proteins share structural homology.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Cellular component | Chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. | ||
| Biological process | DNA metabolic process | Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Meiotic recombination protein SPO11 [Medicago truncatula] gi|357494931|ref|XP_003617754.1| | 9 | ||
| – | PREDICTED: meiotic recombination protein SPO11-1-like [Cicer arietinum] gi|502100203|ref|XP_004491659.1| | 11 | ||
| – | Meiotic recombination protein SPO11 [Medicago truncatula] gi|357494931|ref|XP_003617754.1| | 9 | ||
| – | PREDICTED: meiotic recombination protein SPO11-2-like isoform X2 [Cicer arietinum] gi|502159864|ref|XP_004511556.1| | 11 | ||
| – | PREDICTED: meiotic recombination protein SPO11-2-like isoform X2 [Cicer arietinum] gi|502159864|ref|XP_004511556.1| | 10 | ||
| – | PREDICTED: DNA topoisomerase 6 subunit A-like [Cicer arietinum] gi|502121820|ref|XP_004497452.1| | 15 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|A0A061R4D2|A0A061R4D2_9CHLO DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi2g1v0088900_LC | 9 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A; TrEMBL-Plants: tr|A0A061R4D2|A0A061R4D2_9CHLO DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi2g1v0088900_LC | 9 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|G7KC02|G7KC02_MEDTR Meiotic recombination SPO11-like protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.2 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 11 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|I1LGD2|I1LGD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT1G63990.1 sporulation 11-2; Swiss-Prot: sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2; TrEMBL-Plants: tr|K7LMM4|K7LMM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436400 | 13 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A; TrEMBL-Plants: tr|A0A068F783|A0A068F783_LOTJA DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi5g1v0072800 | 17 | ||
| – | DNA topoisomerase 6 subunit A; TAIR: AT5G02820.1 Spo11/DNA topoisomerase VI, subunit A protein; Swiss-Prot: sp|A2XFC1|TOP6A_ORYSI DNA topoisomerase 6 subunit A3; TrEMBL-Plants: tr|I1H6P7|I1H6P7_BRADI DNA topoisomerase 6 subunit A; Found in the gene: LotjaGi6g1v0346800 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00223 | CDD | 1 | 6.67 |