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IPR016192

Source: InterPro

Description

IPR016192 is a APOBEC/CMP deaminase, zinc-binding.

<p>Cytidine deaminase ([ec:3.5.4.5]) (cytidine aminohydrolase) catalyzes the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase ([ec:3.5.4.12]) (dCMP deaminase) hydrolyzes dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [[cite:PUB00000364], [cite:PUB00002807]]. These two enzymes do not share any sequence similarity with the exception of a region that contains three conserved histidine and cysteine residues which are thought to be involved in the binding of the catalytic zinc ion.</p> <p>Such a region is also found in other proteins [[cite:PUB00005022], [cite:PUB00005412]]:</p> <ul> <li>Yeast cytosine deaminase ([ec:3.5.4.1]) (gene FCY1) which transforms cytosine into uracil.</li> <li>Mammalian apolipoprotein B mRNA editing protein, responsible for the postranscriptional editing of a CAA codon into a UAA (stop) codon in the APOB mRNA.</li> <li>Riboflavin biosynthesis protein ribG, which converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate.</li> <li>Bacillus cereus blasticidin-S deaminase ([ec:3.5.4.23]), which catalyzes the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.</li> <li>Bacillus subtilis protein comEB. This protein is required for the binding and uptake of transforming DNA.</li> <li>B. subtilis hypothetical protein yaaJ.</li> <li>Escherichia coli hypothetical protein yfhC.</li> <li>Yeast hypothetical protein YJL035c.</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of
GO:0016787
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
Subterm of

Associated Lotus transcripts 18

Transcript Name Description Predicted domains Domain count
Lj0g3v0066279.1
– PREDICTED: guanine deaminase-like isoform X1 [Cicer arietinum] gi|502086321|ref|XP_004488180.1|
Domains
11
Lj0g3v0132579.1
– PREDICTED: riboflavin biosynthesis protein RibD-like [Glycine max] gi|356506247|ref|XP_003521898.1|
Domains
16
Lj0g3v0284819.1
– PREDICTED: deoxycytidylate deaminase-like [Cicer arietinum] gi|502176161|ref|XP_004515811.1|
Domains
19
Lj2g3v0912020.1
– Cytidine deaminase [Medicago truncatula] gi|357501295|ref|XP_003620936.1|
Domains
16
Lj4g3v2137110.1
– PREDICTED: tRNA-specific adenosine deaminase 2 [Glycine max] gi|356549373|ref|XP_003543068.1|
Domains
11
Lj4g3v2225630.1
– PREDICTED: tRNA-specific adenosine deaminase-like [Cicer arietinum] gi|502150685|ref|XP_004508073.1|
Domains
11
Lj4g3v3015270.1
– Cytidine deaminase [Medicago truncatula] gi|357520685|ref|XP_003630631.1|
Domains
17
LotjaGi2g1v0233100.1
– Cytidine deaminase; TAIR: AT2G19570.1 cytidine deaminase 1; Swiss-Prot: sp|O65896|CDA1_ARATH Cytidine deaminase 1; TrEMBL-Plants: tr|A0A1J7HS04|A0A1J7HS04_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233100
Domains
16
LotjaGi4g1v0221700.1
– Deoxycytidylate deaminase; TAIR: AT3G48540.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q5RC69|DCTD_PONAB Deoxycytidylate deaminase; TrEMBL-Plants: tr|I1K0B7|I1K0B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0221700
Domains
20
LotjaGi4g1v0305600.1
– Deaminase-related family protein; TAIR: AT1G48175.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q7Z6V5|ADAT2_HUMAN tRNA-specific adenosine deaminase 2; TrEMBL-Plants: tr|A0A0L9TEI2|A0A0L9TEI2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0305600
Domains
11
LotjaGi4g1v0317000.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|I3SAE1|I3SAE1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0317000
Domains
11
LotjaGi4g1v0317000.2
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|I3SAE1|I3SAE1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0317000
Domains
12
LotjaGi4g1v0345400.1
– Riboflavin biosynthesis protein ribD; TAIR: AT4G20960.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q8GWP5|RIBD_ARATH Riboflavin biosynthesis protein PYRD, chloroplastic; TrEMBL-Plants: tr|A0A151T5Q7|A0A151T5Q7_CAJCA Riboflavin biosynthesis protein ribD; Found in the gene: LotjaGi4g1v0345400
Domains
16
LotjaGi5g1v0214600.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|A0A0S3SQ64|A0A0S3SQ64_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
16
LotjaGi5g1v0214600.2
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|K7N544|K7N544_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
12
LotjaGi5g1v0214600.3
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|K7N544|K7N544_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
12
LotjaGi6g1v0218000.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|T2DMP6|T2DMP6_PHAVU Cytidine/deoxycytidylate deaminase; Found in the gene: LotjaGi6g1v0218000
Domains
11
LotjaGi6g1v0218000.3
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|G7IQF5|G7IQF5_MEDTR Cytidine/deoxycytidylate deaminase family protein; Found in the gene: LotjaGi6g1v0218000
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01285 CDD 1 5.56