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IPR002125

Source: InterPro

Description

IPR002125 is a Cytidine and deoxycytidylate deaminase domain.

<p>Cytidine deaminase ([ec:3.5.4.5]) (cytidine aminohydrolase) catalyses the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase ([ec:3.5.4.12]) (dCMP deaminase) hydrolyses dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [[cite:PUB00000364], [cite:PUB00002807]]. The deaminases possess either one or two conserved zinc-coordinating (Z) motifs, with the consensus amino acid signature H-x(1)-E-x(24,28)-P-C-x(2,4)-C. This motif is required for catalytic activity. Zinc coordination is mediated by a histidine and two cysteines [[cite:PUB00054844]]. The CMP/dCMP-type deaminase domain consists of a central β-sheet with one or more α-helices on each side [[cite:PUB00021931]].</p> <p>This entry represents the CMP/dCMP-type deaminase domain. Some enzymes, such as riboflavin biosynthesis protein PYRR, have a non-functional deaminase domain that lacks the catalytically essential zinc-binding residues [[cite:PUB00075557]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 26

Transcript Name Description Predicted domains Domain count
Lj0g3v0066279.1
– PREDICTED: guanine deaminase-like isoform X1 [Cicer arietinum] gi|502086321|ref|XP_004488180.1|
Domains
11
Lj0g3v0132579.1
– PREDICTED: riboflavin biosynthesis protein RibD-like [Glycine max] gi|356506247|ref|XP_003521898.1|
Domains
16
Lj0g3v0284819.1
– PREDICTED: deoxycytidylate deaminase-like [Cicer arietinum] gi|502176161|ref|XP_004515811.1|
Domains
19
Lj1g3v2835980.1
– PREDICTED: riboflavin biosynthesis protein RibD-like [Cicer arietinum] gi|502105588|ref|XP_004492842.1|
Domains
28
Lj2g3v0912020.1
– Cytidine deaminase [Medicago truncatula] gi|357501295|ref|XP_003620936.1|
Domains
16
Lj2g3v1192960.1
– PREDICTED: tRNA-specific adenosine deaminase, chloroplastic-like [Glycine max] gi|356502702|ref|XP_003520156.1|
Domains
12
Lj3g3v1294540.1
– PREDICTED: tRNA-specific adenosine deaminase-like protein 3-like [Glycine max] gi|356547101|ref|XP_003541956.1|
Domains
8
Lj4g3v2137110.1
– PREDICTED: tRNA-specific adenosine deaminase 2 [Glycine max] gi|356549373|ref|XP_003543068.1|
Domains
11
Lj4g3v2225630.1
– PREDICTED: tRNA-specific adenosine deaminase-like [Cicer arietinum] gi|502150685|ref|XP_004508073.1|
Domains
11
Lj4g3v3015270.1
– Cytidine deaminase [Medicago truncatula] gi|357520685|ref|XP_003630631.1|
Domains
17
LotjaGi1g1v0486000.1
– Riboflavin biosynthesis protein RibD; TAIR: AT3G47390.2 cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q9STY4|RIBRX_ARATH Riboflavin biosynthesis protein PYRR, chloroplastic; TrEMBL-Plants: tr|A0A1J7G1G5|A0A1J7G1G5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0486000
Domains
30
LotjaGi2g1v0233100.1
– Cytidine deaminase; TAIR: AT2G19570.1 cytidine deaminase 1; Swiss-Prot: sp|O65896|CDA1_ARATH Cytidine deaminase 1; TrEMBL-Plants: tr|A0A1J7HS04|A0A1J7HS04_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233100
Domains
16
LotjaGi2g1v0284200.1
– TRNA-specific adenosine deaminase; TAIR: AT1G68720.1 tRNA arginine adenosine deaminase; Swiss-Prot: sp|Q9S7I0|TADA_ARATH tRNA(adenine(34)) deaminase, chloroplastic; TrEMBL-Plants: tr|K7K815|K7K815_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0284200
Domains
12
LotjaGi3g1v0183700.1
– TRNA-specific adenosine deaminase; TAIR: AT5G24670.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q6PAT0|ADAT3_MOUSE Probable inactive tRNA-specific adenosine deaminase-like protein 3; TrEMBL-Plants: tr|I3SWE8|I3SWE8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0183700
Domains
7
LotjaGi3g1v0183700.2
– TRNA-specific adenosine deaminase; TAIR: AT5G24670.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q6PAT0|ADAT3_MOUSE Probable inactive tRNA-specific adenosine deaminase-like protein 3; TrEMBL-Plants: tr|I3SWE8|I3SWE8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0183700
Domains
7
LotjaGi3g1v0183700.3
– TRNA-specific adenosine deaminase; TAIR: AT5G24670.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q6PAT0|ADAT3_MOUSE Probable inactive tRNA-specific adenosine deaminase-like protein 3; TrEMBL-Plants: tr|I3SWE8|I3SWE8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0183700
Domains
7
LotjaGi4g1v0221700.1
– Deoxycytidylate deaminase; TAIR: AT3G48540.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q5RC69|DCTD_PONAB Deoxycytidylate deaminase; TrEMBL-Plants: tr|I1K0B7|I1K0B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0221700
Domains
20
LotjaGi4g1v0305600.1
– Deaminase-related family protein; TAIR: AT1G48175.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q7Z6V5|ADAT2_HUMAN tRNA-specific adenosine deaminase 2; TrEMBL-Plants: tr|A0A0L9TEI2|A0A0L9TEI2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0305600
Domains
11
LotjaGi4g1v0317000.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|I3SAE1|I3SAE1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0317000
Domains
11
LotjaGi4g1v0317000.2
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|I3SAE1|I3SAE1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0317000
Domains
12
LotjaGi4g1v0345400.1
– Riboflavin biosynthesis protein ribD; TAIR: AT4G20960.1 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|Q8GWP5|RIBD_ARATH Riboflavin biosynthesis protein PYRD, chloroplastic; TrEMBL-Plants: tr|A0A151T5Q7|A0A151T5Q7_CAJCA Riboflavin biosynthesis protein ribD; Found in the gene: LotjaGi4g1v0345400
Domains
16
LotjaGi5g1v0214600.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|A0A0S3SQ64|A0A0S3SQ64_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
16
LotjaGi5g1v0214600.2
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|K7N544|K7N544_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
12
LotjaGi5g1v0214600.3
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|K7N544|K7N544_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0214600
Domains
12
LotjaGi6g1v0218000.1
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|T2DMP6|T2DMP6_PHAVU Cytidine/deoxycytidylate deaminase; Found in the gene: LotjaGi6g1v0218000
Domains
11
LotjaGi6g1v0218000.3
– Deaminase-related family protein; TAIR: AT5G28050.3 Cytidine/deoxycytidylate deaminase family protein; Swiss-Prot: sp|O34598|GUAD_BACSU Guanine deaminase; TrEMBL-Plants: tr|G7IQF5|G7IQF5_MEDTR Cytidine/deoxycytidylate deaminase family protein; Found in the gene: LotjaGi6g1v0218000
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01285 CDD 1 3.85