Description

IPR039421 is a Type 1 protein exporter.

<p>Proteins in this entry are required for type I protein secretion and have an N-terminal ABC transporter type 1 transmembrane domain and a C-terminal P-loop containing nucleoside triphosphate hydrolase domain. The transmembrane domain forms a pore in the inner membrane and the ATP-binding domain is responsible for energy generation. Sequences are mainly from bacteria, but there are homologues from eukaryotes and archaea. Proteins in this entry include the following:</p> <ul><li>Lipid A export ATP-binding/permease protein MsbA, which is required for lipid A and possibly glycerophospholipid transport, and for biogenesis of the outer membrane in bacteria [[cite:PUB00053164]]</li> <li>Beta-(1-->2)glucan export ATP-binding/permease protein NdvA from nitrogen-fixing bacteria, which is required for beta-(1-->2)glucan export, essential for nodule formation in legume roots [[cite:PUB00060286]]</li> <li>Iron-sulfur clusters transporter ATM1, a yeast mitochondrial protein that exports Fe/S cluster-containing protein precursors and other mitochondrially synthesized proteins to the cytoplasm [[cite:PUB00089675]]. The mammalian equivalents are the ATP-binding cassette sub-family B members 6, 7, 8 and 9, which are required for the transport of heme and porphyrin from the cytoplasm to the mitochondrion [[cite:PUB00072084]]</li> <li>Leukotoxin translocation ATP-binding protein LktB, required for leukotoxin export in<i>Mannheimia haemolytica</i></li> <li>Multidrug resistance protein 1, which exports xenobiotics, such as cytotoxic drugs, out of cells leading to tumour cell resistance to multiple drugs [[cite:PUB00089676]]. The bacterial equivalents include multidrug resistance-like ATP-binding protein MdlA</li> <li>Alpha-hemolysin translocation ATP-binding protein HlyB from<i>E. coli</i>, a component of the ABC transporter complex HlyBD required for the export of hemolysin [[cite:PUB00089677]]</li> <li>Phosphatidylcholine translocator ABCB4, required for lipid secretion in the bile, transporting phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes [[cite:PUB00089678]]</li> <li>Bile salt export pump, required for the secretion of bile salts into the canaliculus of hepatocytes [[cite:PUB00089679]]</li> <li>Antigen peptide transporter 1, which is required for the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules [[cite:PUB00089680]]</li> <li>P-glycoprotein 14 which exports polar lipids into the developing pharyngeal cuticle to protect against xenobiotic insult [[cite:PUB00154511]]. PGP-14 has an internal duplication and two copies of the constituent domains.</li></ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 82