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IPR004140

Source: InterPro

Description

IPR004140 is a Exocyst complex component Exo70.

<p>The Exo70 protein forms one subunit of the exocyst complex (consist of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 in budding yeast). First discovered in Saccharomyces cerevisiae [[cite:PUB00007377]], it is evolutionarily conserved in eukaryotes. It mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for membrane fusion. It also plays a role in cell polarisation, primary ciliogenesis, cytokinesis, pathogen invasion, tumourigenesis and metastasis [[cite:PUB00100048]]. It is a member of the the Complex Associated with Tethering Containing Helical Rods (CATCHRs) family which also includes Conserved Oligomeric Golgi complex (COG) and Golgi-Associated Retrograde Protein complex (GARP) and DSL1 complexes, all evolutionarily related and share structural features consisting of α-helical bundles at the C terminus and coiled-coil region at the N terminus [[cite:PUB00100048], [cite:PUB00007380], [cite:PUB00100047], [cite:PUB00100078]]. Exo70 interacts with phospholipids the Rho3 GTPase [[cite:PUB00007378], [cite:PUB00033660]]. This interaction with Rho3 mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud) [[cite:PUB00007379]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000145
Cellular component Exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
Subterm of
GO:0006887
Biological process Exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Subterm of

Associated Lotus transcripts 50

Transcript Name Description Predicted domains Domain count
Lj0g3v0078039.1
– Exocyst complex component [Medicago truncatula] gi|357491281|ref|XP_003615928.1|
Domains
6
Lj0g3v0078049.1
– Exocyst complex component [Medicago truncatula] gi|357491281|ref|XP_003615928.1|
Domains
6
Lj0g3v0080899.1
–
Domains
3
Lj0g3v0083399.1
– Exocyst complex component [Medicago truncatula] gi|357437557|ref|XP_003589054.1|
Domains
8
Lj0g3v0214899.1
– PREDICTED: exocyst complex component 7-like [Glycine max] gi|356502247|ref|XP_003519931.1|
Domains
7
Lj0g3v0214909.1
– PREDICTED: exocyst complex component 7-like [Glycine max] gi|356502247|ref|XP_003519931.1|
Domains
7
Lj0g3v0291869.1
– Exocyst complex component [Medicago truncatula] gi|357477099|ref|XP_003608835.1|
Domains
7
Lj0g3v0294369.1
– Exocyst subunit exo70 family protein A2 isoform 2 [Theobroma cacao] gi|508716560|gb|EOY08457.1|
Domains
6
Lj0g3v0294369.2
– PREDICTED: exocyst complex component 7-like isoform 1 [Glycine max] gi|356550590|ref|XP_003543668.1|
Domains
6
Lj0g3v0298809.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502118127|ref|XP_004496114.1|
Domains
10
Lj0g3v0305379.1
– Exocyst complex component [Medicago truncatula] gi|357491191|ref|XP_003615883.1|
Domains
6
Lj0g3v0313429.1
– Exocyst complex component [Medicago truncatula] gi|357472627|ref|XP_003606598.1|
Domains
6
Lj1g3v3022340.1
–
Domains
8
Lj1g3v3891950.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502102704|ref|XP_004492158.1|
Domains
7
Lj1g3v4578460.1
– Exocyst subunit exo70 family protein H4 [Theobroma cacao] gi|508715738|gb|EOY07635.1|
Domains
6
Lj1g3v4969950.1
– Exocyst complex component [Medicago truncatula] gi|357454067|ref|XP_003597314.1|
Domains
6
Lj2g3v1647670.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502096226|ref|XP_004490667.1|
Domains
6
Lj2g3v1659230.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502096226|ref|XP_004490667.1|
Domains
8
Lj2g3v2314840.1
–
Domains
7
Lj2g3v2314840.2
–
Domains
14
Lj2g3v2314850.1
– Leucine zipper protein [Medicago truncatula] gi|357491217|ref|XP_003615896.1|
Domains
21
Lj2g3v2364680.1
– Leucine zipper protein [Medicago truncatula] gi|357491253|ref|XP_003615914.1|
Domains
7
Lj2g3v2364680.2
– Exocyst complex component [Medicago truncatula] gi|357491281|ref|XP_003615928.1|
Domains
12
Lj2g3v2364710.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502096226|ref|XP_004490667.1|
Domains
6
Lj3g3v2043280.1
– PREDICTED: exocyst complex component 7-like [Vitis vinifera] gi|225429756|ref|XP_002280486.1|
Domains
6
Lj3g3v2576530.1
– PREDICTED: exocyst complex component 7-like [Cicer arietinum] gi|502156542|ref|XP_004510526.1|
Domains
7
Lj3g3v2863540.1
– Exocyst subunit exo70 family protein G1 [Theobroma cacao] gi|508781976|gb|EOY29232.1|
Domains
8
Lj4g3v1388270.1
– Exocyst complex component [Medicago truncatula] gi|357477099|ref|XP_003608835.1|
Domains
7
Lj5g3v1697800.1
– Exocyst complex component EXO70 [Medicago truncatula] gi|357442821|ref|XP_003591688.1|
Domains
7
Lj5g3v1697800.2
– Exocyst complex component EXO70 [Medicago truncatula] gi|357442821|ref|XP_003591688.1|
Domains
6
LotjaGi1g1v0112400.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A0R0GS25|A0A0R0GS25_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0112400
Domains
11
LotjaGi1g1v0112500.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A0B2QH88|A0A0B2QH88_GLYSO Exocyst complex component 7; Found in the gene: LotjaGi1g1v0112500
Domains
8
LotjaGi1g1v0112600.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|G7JZR6|G7JZR6_MEDTR Exocyst subunit exo70 family protein; Found in the gene: LotjaGi1g1v0112600
Domains
15
LotjaGi1g1v0112700.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A151U109|A0A151U109_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi1g1v0112700
Domains
7
LotjaGi1g1v0116800.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|G7JZR6|G7JZR6_MEDTR Exocyst subunit exo70 family protein; Found in the gene: LotjaGi1g1v0116800
Domains
15
LotjaGi1g1v0512500.1
– Exocyst complex component, putative; TAIR: AT3G29400.1 exocyst subunit exo70 family protein E1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A151TCH8|A0A151TCH8_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi1g1v0512500
Domains
8
LotjaGi1g1v0512500.2
– Exocyst complex component, putative; TAIR: AT3G29400.1 exocyst subunit exo70 family protein E1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A151TCH8|A0A151TCH8_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi1g1v0512500
Domains
8
LotjaGi1g1v0696800.1
– Exocyst complex component, putative; TAIR: AT3G09520.1 exocyst subunit exo70 family protein H4; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|I1NA18|I1NA18_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0696800
Domains
8
LotjaGi2g1v0103800.1
– Exocyst complex component, putative; TAIR: AT5G13990.1 exocyst subunit exo70 family protein C2; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A151QWD5|A0A151QWD5_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi2g1v0103800
Domains
9
LotjaGi2g1v0367600.1
– Exocyst complex component, putative; TAIR: AT5G59730.2 exocyst subunit exo70 family protein H7; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|I1LK82|I1LK82_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0367600
Domains
7
LotjaGi2g1v0376400.1
– Exocyst complex component, putative; TAIR: AT5G58430.1 exocyst subunit exo70 family protein B1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A151U109|A0A151U109_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi2g1v0376400
Domains
9
LotjaGi3g1v0278900.1
– Exocyst complex component, putative; TAIR: AT5G59730.2 exocyst subunit exo70 family protein H7; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|A0A151SUV6|A0A151SUV6_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi3g1v0278900
Domains
8
LotjaGi3g1v0412200.1
– Exocyst complex component, putative; TAIR: AT1G72470.1 exocyst subunit exo70 family protein D1; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|A0A1J7GPX5|A0A1J7GPX5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0412200
Domains
8
LotjaGi3g1v0412200.2
– Exocyst complex component, putative; TAIR: AT1G72470.1 exocyst subunit exo70 family protein D1; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|A0A1J7GPX5|A0A1J7GPX5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0412200
Domains
8
LotjaGi4g1v0222100.1
– Exocyst complex component, putative; TAIR: AT5G50380.1 exocyst subunit exo70 family protein F1; Swiss-Prot: sp|Q9FGH9|E70B1_ARATH Exocyst complex component EXO70B1; TrEMBL-Plants: tr|A0A0L9TR87|A0A0L9TR87_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0222100
Domains
7
LotjaGi5g1v0034000.1
– Exocyst complex component 7; TAIR: AT4G31540.1 exocyst subunit exo70 family protein G1; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|G7IBC1|G7IBC1_MEDTR Exocyst subunit exo70 family protein; Found in the gene: LotjaGi5g1v0034000
Domains
9
LotjaGi5g1v0066500.1
– Exocyst complex component 7; TAIR: AT4G31540.1 exocyst subunit exo70 family protein G1; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|G7I5R5|G7I5R5_MEDTR Exocyst complex exo70-like protein; Found in the gene: LotjaGi5g1v0066500
Domains
8
LotjaGi5g1v0104800.1
– Exocyst complex component, putative; TAIR: AT5G52340.1 exocyst subunit exo70 family protein A2; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|A0A151RD29|A0A151RD29_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi5g1v0104800
Domains
7
LotjaGi5g1v0104800.2
– Exocyst complex component, putative; TAIR: AT5G52340.1 exocyst subunit exo70 family protein A2; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|A0A151RD29|A0A151RD29_CAJCA Exocyst complex component 7; Found in the gene: LotjaGi5g1v0104800
Domains
7
LotjaGi5g1v0255400.1
– Exocyst complex component, putative; TAIR: AT5G03540.1 exocyst subunit exo70 family protein A1; Swiss-Prot: sp|Q9LZD3|E70A1_ARATH Exocyst complex component EXO70A1; TrEMBL-Plants: tr|G7I413|G7I413_MEDTR Exocyst subunit exo70 family protein; Found in the gene: LotjaGi5g1v0255400
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.00