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IPR004837

Source: InterPro

Description

IPR004837 is a Sodium/calcium exchanger membrane region.

<p>The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [[cite:PUB00005133]]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [[cite:PUB00005133]]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [[cite:PUB00002973]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016021
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Subterm of
GO:0055085
Biological process Transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
Subterm of

Associated Lotus transcripts 33

Transcript Name Description Predicted domains Domain count
Lj0g3v0072889.1
– Sodium/calcium exchanger family protein / calcium-binding EF hand family protein isoform 1 [Theobroma cacao] gi|508721276|gb|EOY13173.1|
Domains
18
Lj0g3v0072889.2
– Sodium/calcium exchanger family protein / calcium-binding EF hand family protein isoform 1 [Theobroma cacao] gi|508721276|gb|EOY13173.1|
Domains
23
Lj0g3v0087469.1
– PREDICTED: cation/calcium exchanger 3-like [Glycine max] gi|356573879|ref|XP_003555083.1|
Domains
8
Lj0g3v0092169.1
– PREDICTED: cation/calcium exchanger 2-like [Cicer arietinum] gi|502091852|ref|XP_004489652.1|
Domains
8
Lj0g3v0133059.1
– Sodium/calcium exchanger family protein / calcium-binding EF hand family protein isoform 2 [Theobroma cacao] gi|508721277|gb|EOY13174.1|
Domains
24
Lj0g3v0306909.1
– PREDICTED: vacuolar cation/proton exchanger 2-like [Glycine max] gi|356556151|ref|XP_003546390.1|
Domains
10
Lj1g3v2315450.1
– PREDICTED: vacuolar cation/proton exchanger 3-like [Glycine max] gi|356521008|ref|XP_003529150.1|
Domains
12
Lj1g3v3979370.1
– PREDICTED: cation/calcium exchanger 4-like [Glycine max] gi|356571781|ref|XP_003554051.1|
Domains
8
Lj1g3v3980440.1
– Cation/calcium exchanger [Medicago truncatula] gi|357508857|ref|XP_003624717.1|
Domains
8
Lj1g3v4931780.1
– PREDICTED: cation/calcium exchanger 5-like isoform X1 [Cicer arietinum] gi|502113376|ref|XP_004494630.1|
Domains
8
Lj2g3v2256320.1
– PREDICTED: vacuolar cation/proton exchanger 1-like [Glycine max] gi|356498943|ref|XP_003518305.1|
Domains
8
Lj3g3v2576760.1
– PREDICTED: cation/calcium exchanger 4-like [Glycine max] gi|356558954|ref|XP_003547767.1|
Domains
9
Lj5g3v1616840.1
– PREDICTED: magnesium/proton exchanger-like isoform X1 [Cicer arietinum] gi|502117788|ref|XP_004495946.1|
Domains
7
Lj6g3v0658950.1
– PREDICTED: vacuolar cation/proton exchanger 5-like [Glycine max] gi|356524415|ref|XP_003530824.1|
Domains
12
Lj6g3v0658950.2
– PREDICTED: vacuolar cation/proton exchanger 5-like [Glycine max] gi|356524415|ref|XP_003530824.1|
Domains
8
LotjaGi1g1v0120600.1
– Vacuolar cation/proton exchanger, putative; TAIR: AT2G38170.1 cation exchanger 1; Swiss-Prot: sp|Q39253|CAX1_ARATH Vacuolar cation/proton exchanger 1; TrEMBL-Plants: tr|I1JHC6|I1JHC6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0120600
Domains
15
LotjaGi1g1v0120600.2
– Vacuolar cation/proton exchanger, putative; TAIR: AT2G38170.3 cation exchanger 1; Swiss-Prot: sp|Q39253|CAX1_ARATH Vacuolar cation/proton exchanger 1; TrEMBL-Plants: tr|I1JHC6|I1JHC6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0120600
Domains
15
LotjaGi1g1v0440900.1
– Vacuolar cation/proton exchanger, putative; TAIR: AT3G51860.1 cation exchanger 3; Swiss-Prot: sp|Q93Z81|CAX3_ARATH Vacuolar cation/proton exchanger 3; TrEMBL-Plants: tr|I1KKE4|I1KKE4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0440900
Domains
14
LotjaGi1g1v0648400.1
– Cation calcium exchanger; TAIR: AT5G17860.1 calcium exchanger 7; Swiss-Prot: sp|Q9FKP1|CCX1_ARATH Cation/calcium exchanger 1; TrEMBL-Plants: tr|I1N8E0|I1N8E0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0648400
Domains
10
LotjaGi1g1v0648500.1
– Cation calcium exchanger; TAIR: AT5G17850.1 Sodium/calcium exchanger family protein; Swiss-Prot: sp|Q9FKP2|CCX2_ARATH Cation/calcium exchanger 2; TrEMBL-Plants: tr|A0A0L9U817|A0A0L9U817_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0648500
Domains
9
LotjaGi1g1v0774600.1
– Cation calcium exchanger; TAIR: AT1G08960.1 cation exchanger 11; Swiss-Prot: sp|O04034|CCX5_ARATH Cation/calcium exchanger 5; TrEMBL-Plants: tr|I1JRE5|I1JRE5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0774600
Domains
10
LotjaGi2g1v0110900.1
– Cation calcium exchanger; TAIR: AT5G17850.1 Sodium/calcium exchanger family protein; Swiss-Prot: sp|Q9FKP2|CCX2_ARATH Cation/calcium exchanger 2; TrEMBL-Plants: tr|A0A072U845|A0A072U845_MEDTR Cation calcium exchanger; Found in the gene: LotjaGi2g1v0110900
Domains
10
LotjaGi2g1v0111000.1
– Cation calcium exchanger; TAIR: AT5G17860.1 calcium exchanger 7; Swiss-Prot: sp|Q9FKP1|CCX1_ARATH Cation/calcium exchanger 1; TrEMBL-Plants: tr|V7C2F1|V7C2F1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0111000
Domains
9
LotjaGi3g1v0002000.1
– Vacuolar cation/proton exchanger, putative; TAIR: AT3G13320.1 cation exchanger 2; Swiss-Prot: sp|Q5KQN0|CAX2_ORYSJ Vacuolar cation/proton exchanger 2; TrEMBL-Plants: tr|A0A151S6K9|A0A151S6K9_CAJCA Vacuolar cation/proton exchanger 2; Found in the gene: LotjaGi3g1v0002000
Domains
14
LotjaGi3g1v0002000.2
– Vacuolar cation/proton exchanger, putative; TAIR: AT3G13320.1 cation exchanger 2; Swiss-Prot: sp|Q5KQN0|CAX2_ORYSJ Vacuolar cation/proton exchanger 2; TrEMBL-Plants: tr|A0A151S6K9|A0A151S6K9_CAJCA Vacuolar cation/proton exchanger 2; Found in the gene: LotjaGi3g1v0002000
Domains
14
LotjaGi3g1v0002000.3
– Vacuolar cation/proton exchanger, putative; TAIR: AT3G13320.1 cation exchanger 2; Swiss-Prot: sp|Q5KQN0|CAX2_ORYSJ Vacuolar cation/proton exchanger 2; TrEMBL-Plants: tr|A0A151S6K9|A0A151S6K9_CAJCA Vacuolar cation/proton exchanger 2; Found in the gene: LotjaGi3g1v0002000
Domains
14
LotjaGi3g1v0154400.1
– Calcium ion binding protein, putative; TAIR: AT1G53210.1 sodium/calcium exchanger family protein / calcium-binding EF hand family protein; Swiss-Prot: sp|Q8L783|CAX5_ARATH Vacuolar cation/proton exchanger 5; TrEMBL-Plants: tr|V7BXV4|V7BXV4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0154400
Domains
23
LotjaGi3g1v0154800.1
– Calcium binding family protein; TAIR: AT1G53210.1 sodium/calcium exchanger family protein / calcium-binding EF hand family protein; Swiss-Prot: sp|Q9N1R0|CABP1_BOVIN Calcium-binding protein 1; TrEMBL-Plants: tr|K7M290|K7M290_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0154800
Domains
27
LotjaGi3g1v0413000.1
– Cation calcium exchanger; TAIR: AT1G54115.1 cation calcium exchanger 4; Swiss-Prot: sp|Q9SYG9|CCX4_ARATH Cation/calcium exchanger 4; TrEMBL-Plants: tr|A0A0B2S5Q2|A0A0B2S5Q2_GLYSO Cation/calcium exchanger 4; Found in the gene: LotjaGi3g1v0413000
Domains
10
LotjaGi5g1v0250200.1
– Sodium/calcium exchanger 1; TAIR: AT2G47600.1 magnesium/proton exchanger; Swiss-Prot: sp|O22252|MHX_ARATH Magnesium/proton exchanger; TrEMBL-Plants: tr|V7BEQ2|V7BEQ2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0250200
Domains
9
LotjaGi5g1v0250200.2
– Sodium/calcium exchanger 1; TAIR: AT2G47600.1 magnesium/proton exchanger; Swiss-Prot: sp|O22252|MHX_ARATH Magnesium/proton exchanger; TrEMBL-Plants: tr|V7BEQ2|V7BEQ2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0250200
Domains
9
LotjaGi6g1v0137700.1
– Vacuolar cation/proton exchanger, putative; TAIR: AT1G55730.1 cation exchanger 5; Swiss-Prot: sp|Q8L783|CAX5_ARATH Vacuolar cation/proton exchanger 5; TrEMBL-Plants: tr|K7LAF5|K7LAF5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0137700
Domains
14
LotjaGi6g1v0137700.2
– Vacuolar cation/proton exchanger, putative; TAIR: AT1G55730.1 cation exchanger 5; Swiss-Prot: sp|Q8L783|CAX5_ARATH Vacuolar cation/proton exchanger 5; TrEMBL-Plants: tr|K7LAF5|K7LAF5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0137700
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 3.03