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IPR005512 is a PRONE domain.
<p>In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and atRac in Arabidopsis thaliana belong to the Rho family of Ras-related GTP-binding proteins that turn on signalling pathways by switching from a GDP-bound inactive to a GTP-bound active conformation. Activation depends on guanine nucleotide exchange factors (GEFs) that catalyse the otherwise slow GDP dissociation for subsequent GTP binding. The plant-specific RopGEFs represent a unique family of exchange factor that display no homology to any known RhoGEFs from animals and fungi. They comprise a highly conserved catalytic domain termed PRONE (plant-specific Rop nucleotide exchanger) with exclusive substrate specificity for members of the Rop family. The PRONE domain has been shown to be necessary and sufficient to promote nucleotide release from Rop [[cite:PUB00043712], [cite:PUB00043713], [cite:PUB00043714]].</p> <p>The PRONE domain can be divided into three highly conserved subdomains separated by two short stretches of variable amino acid residues [[cite:PUB00043712], [cite:PUB00043713]]. It is approximately 370 residues in length and displays an almost all α-helical structure except for a β-turn that protrudes from the main body of the molecule. The overall structure of the PRONE domain can be divided into two subdomains, the first one including helices alpha1-5 and alpha13, the second alpha6-12 [[cite:PUB00042041], [cite:PUB00043714]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Rho guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Cicer arietinum] gi|502147590|ref|XP_004506840.1| | 6 | ||
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Cicer arietinum] gi|502147590|ref|XP_004506840.1| | 6 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: rop guanine nucleotide exchange factor 1-like [Glycine max] gi|356553808|ref|XP_003545244.1| | 6 | ||
| – | Rop guanine nucleotide exchange factor [Medicago truncatula] gi|357492475|ref|XP_003616526.1| | 5 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 1-like [Glycine max] gi|356559061|ref|XP_003547820.1| | 7 | ||
| – | Rop guanine nucleotide exchange factor [Medicago truncatula] gi|357492475|ref|XP_003616526.1| | 6 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 2-like isoform 1 [Glycine max] gi|356568388|ref|XP_003552393.1| | 7 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 2-like isoform 2 [Glycine max] gi|356568390|ref|XP_003552394.1| | 6 | ||
| – | RopGEF7b [Medicago truncatula] gi|332688647|gb|AEE89676.1| | 6 | ||
| – | Rop guanine nucleotide exchange factor [Medicago truncatula] gi|357500637|ref|XP_003620607.1| | 5 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 1-like [Glycine max] gi|356496475|ref|XP_003517093.1| | 5 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 1-like [Glycine max] gi|356496475|ref|XP_003517093.1| | 6 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 1-like [Glycine max] gi|356539905|ref|XP_003538433.1| | 6 | ||
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Glycine max] gi|356557277|ref|XP_003546944.1| | 7 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: rop guanine nucleotide exchange factor 2-like [Glycine max] gi|356520430|ref|XP_003528865.1| | 7 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 2-like [Glycine max] gi|356504716|ref|XP_003521141.1| | 6 | ||
| – | PREDICTED: rop guanine nucleotide exchange factor 1-like isoform 1 [Glycine max] gi|356544030|ref|XP_003540459.1| | 6 | ||
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Cicer arietinum] gi|502147590|ref|XP_004506840.1| | 5 | ||
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Glycine max] gi|356523072|ref|XP_003530166.1| | 5 | ||
| – | PREDICTED: rho guanine nucleotide exchange factor 8-like [Glycine max] gi|356523072|ref|XP_003530166.1| | 5 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G05940.1 ROP guanine nucleotide exchange factor 5; Swiss-Prot: sp|F4K295|ROGF5_ARATH Rop guanine nucleotide exchange factor 5; TrEMBL-Plants: tr|A0A1J7GUE4|A0A1J7GUE4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0084000 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G05940.1 ROP guanine nucleotide exchange factor 5; Swiss-Prot: sp|F4K295|ROGF5_ARATH Rop guanine nucleotide exchange factor 5; TrEMBL-Plants: tr|A0A0B2QH98|A0A0B2QH98_GLYSO Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi1g1v0084000 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G05940.1 ROP guanine nucleotide exchange factor 5; Swiss-Prot: sp|F4K295|ROGF5_ARATH Rop guanine nucleotide exchange factor 5; TrEMBL-Plants: tr|A0A151R4W2|A0A151R4W2_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi1g1v0084500_LC | 7 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G02010.1 RHO guanyl-nucleotide exchange factor 7; Swiss-Prot: sp|Q9LZN0|ROGF7_ARATH Rop guanine nucleotide exchange factor 7; TrEMBL-Plants: tr|A0A151U163|A0A151U163_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi1g1v0084700_LC | 7 | ||
| – | Rop guanine nucleotide exchange factor-like protein; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|I1KGN8|I1KGN8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0391700_LC | 7 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G01700.1 RHO guanyl-nucleotide exchange factor 2; Swiss-Prot: sp|Q9LQ89|ROGF2_ARATH Rop guanine nucleotide exchange factor 2; TrEMBL-Plants: tr|A0A151TAZ6|A0A151TAZ6_CAJCA Rop guanine nucleotide exchange factor 2; Found in the gene: LotjaGi1g1v0476400 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G01700.2 RHO guanyl-nucleotide exchange factor 2; Swiss-Prot: sp|Q9LQ89|ROGF2_ARATH Rop guanine nucleotide exchange factor 2; TrEMBL-Plants: tr|A0A0L9U3X8|A0A0L9U3X8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0476400 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G01700.1 RHO guanyl-nucleotide exchange factor 2; Swiss-Prot: sp|Q9LQ89|ROGF2_ARATH Rop guanine nucleotide exchange factor 2; TrEMBL-Plants: tr|A0A151TAZ6|A0A151TAZ6_CAJCA Rop guanine nucleotide exchange factor 2; Found in the gene: LotjaGi1g1v0476400 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT4G00460.2 RHO guanyl-nucleotide exchange factor 3; Swiss-Prot: sp|A4IJ27|ROGF3_ARATH Rop guanine nucleotide exchange factor 3; TrEMBL-Plants: tr|K7MU94|K7MU94_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0476400 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G01700.1 RHO guanyl-nucleotide exchange factor 2; Swiss-Prot: sp|Q9LQ89|ROGF2_ARATH Rop guanine nucleotide exchange factor 2; TrEMBL-Plants: tr|A0A151TAZ6|A0A151TAZ6_CAJCA Rop guanine nucleotide exchange factor 2; Found in the gene: LotjaGi1g1v0476400 | 9 | ||
| – | Rop guanine nucleotide exchange factor-like protein; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|I1KGN8|I1KGN8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0496100_LC | 7 | ||
| – | Rop guanine nucleotide exchange factor-like protein; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|K7M904|K7M904_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0496100_LC | 7 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G02010.1 RHO guanyl-nucleotide exchange factor 7; Swiss-Prot: sp|Q9LZN0|ROGF7_ARATH Rop guanine nucleotide exchange factor 7; TrEMBL-Plants: tr|A0A151QTL3|A0A151QTL3_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi1g1v0577200 | 8 | ||
| – | Rop guanine nucleotide exchange factor; TAIR: AT3G24620.1 RHO guanyl-nucleotide exchange factor 8; Swiss-Prot: sp|Q9LV40|ROGF8_ARATH Rho guanine nucleotide exchange factor 8; TrEMBL-Plants: tr|I1KIP8|I1KIP8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0218300 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G31650.2 RHO guanyl-nucleotide exchange factor 14; Swiss-Prot: sp|Q56WM6|ROGFE_ARATH Rop guanine nucleotide exchange factor 14; TrEMBL-Plants: tr|K7K403|K7K403_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0347200 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G31650.2 RHO guanyl-nucleotide exchange factor 14; Swiss-Prot: sp|Q56WM6|ROGFE_ARATH Rop guanine nucleotide exchange factor 14; TrEMBL-Plants: tr|K7K403|K7K403_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0347200 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G31650.1 RHO guanyl-nucleotide exchange factor 14; Swiss-Prot: sp|Q56WM6|ROGFE_ARATH Rop guanine nucleotide exchange factor 14; TrEMBL-Plants: tr|K7K403|K7K403_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0347200 | 7 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G31650.2 RHO guanyl-nucleotide exchange factor 14; Swiss-Prot: sp|Q56WM6|ROGFE_ARATH Rop guanine nucleotide exchange factor 14; TrEMBL-Plants: tr|K7K403|K7K403_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0347200 | 8 | ||
| – | Rop guanine nucleotide exchange factor-like protein; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|K7M904|K7M904_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0018200 | 10 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G02010.1 RHO guanyl-nucleotide exchange factor 7; Swiss-Prot: sp|Q9LZN0|ROGF7_ARATH Rop guanine nucleotide exchange factor 7; TrEMBL-Plants: tr|A0A151SMC0|A0A151SMC0_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi3g1v0222000 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G02010.1 RHO guanyl-nucleotide exchange factor 7; Swiss-Prot: sp|Q9LZN0|ROGF7_ARATH Rop guanine nucleotide exchange factor 7; TrEMBL-Plants: tr|A0A151SMC0|A0A151SMC0_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi3g1v0222000 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G02010.1 RHO guanyl-nucleotide exchange factor 7; Swiss-Prot: sp|Q9LZN0|ROGF7_ARATH Rop guanine nucleotide exchange factor 7; TrEMBL-Plants: tr|A0A151SMC0|A0A151SMC0_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi3g1v0222000 | 9 | ||
| – | Rop guanine nucleotide exchange factor-like protein; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|V7AQ39|V7AQ39_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0366900 | 10 | ||
| – | Rop guanine nucleotide exchange factor; TAIR: AT1G79860.1 RHO guanyl-nucleotide exchange factor 12; Swiss-Prot: sp|Q9CA89|ROGFC_ARATH Rop guanine nucleotide exchange factor 12; TrEMBL-Plants: tr|V7AQ39|V7AQ39_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0366900 | 8 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT4G00460.2 RHO guanyl-nucleotide exchange factor 3; Swiss-Prot: sp|A4IJ27|ROGF3_ARATH Rop guanine nucleotide exchange factor 3; TrEMBL-Plants: tr|V7AS76|V7AS76_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0383300 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT4G00460.2 RHO guanyl-nucleotide exchange factor 3; Swiss-Prot: sp|A4IJ27|ROGF3_ARATH Rop guanine nucleotide exchange factor 3; TrEMBL-Plants: tr|V7AS76|V7AS76_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0383300 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT4G00460.2 RHO guanyl-nucleotide exchange factor 3; Swiss-Prot: sp|A4IJ27|ROGF3_ARATH Rop guanine nucleotide exchange factor 3; TrEMBL-Plants: tr|V7AS76|V7AS76_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0383300 | 8 | ||
| – | Rop guanine nucleotide exchange factor; TAIR: AT4G38430.1 rho guanyl-nucleotide exchange factor 1; Swiss-Prot: sp|Q93ZY2|ROGF1_ARATH Rop guanine nucleotide exchange factor 1; TrEMBL-Plants: tr|A0A0S3SE88|A0A0S3SE88_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0533000 | 8 | ||
| – | Rop guanine nucleotide exchange factor; TAIR: AT4G38430.1 rho guanyl-nucleotide exchange factor 1; Swiss-Prot: sp|Q93ZY2|ROGF1_ARATH Rop guanine nucleotide exchange factor 1; TrEMBL-Plants: tr|A0A0S3SE88|A0A0S3SE88_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0533000 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT1G31650.1 RHO guanyl-nucleotide exchange factor 14; Swiss-Prot: sp|Q56WM6|ROGFE_ARATH Rop guanine nucleotide exchange factor 14; TrEMBL-Plants: tr|K7MGA4|K7MGA4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0142800 | 9 | ||
| – | Rop guanine nucleotide exchange factor, putative; TAIR: AT5G05940.1 ROP guanine nucleotide exchange factor 5; Swiss-Prot: sp|F4K295|ROGF5_ARATH Rop guanine nucleotide exchange factor 5; TrEMBL-Plants: tr|A0A151R4W2|A0A151R4W2_CAJCA Rop guanine nucleotide exchange factor 1; Found in the gene: LotjaGi6g1v0068200 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 1.96 |