Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR009637

Source: InterPro

Description

IPR009637 is a Transmembrane protein GPR107/GPR108-like.

<p>This entry represents a group of transmembrane proteins, including mammalian GPR107, GPR108, TMEM87A and TMEM87B which have been collectively termed lung seven transmembrane receptor or LUSTR and are evolutionary related. Together with GPR180, TMEM145, TMEM181, and WLS, they have been described as GOST proteins (for GOLD domain seven-transmembrane helix proteins) given they share the same domain architecture consisting of a GOLD domain atop of a membrane-spanning seven-transmembrane helix domain [[cite:PUB00151072]].</p> <p>GPR107 and GPR108 localize to the Golgi and have suggested roles in protein trafficking [[cite:PUB00151072], [cite:PUB00077130]]. GPR107 is implicated in the transport of Pseudomonas aeruginosa Exotoxin A, Campylobacter jejuni cytolethal distending toxin (CDT), and ricin, while GPR107 knockout cells display deficits in receptor-mediated endocytosis and recycling [[cite:PUB00151075]]. GPR108 is critical for the transduction of a majority of AAV serotypes [[cite:PUB00151074], [cite:PUB00151076]]. It may play a potential role in the regulation of Toll-like receptor-mediated signaling [[cite:PUB00151073]].</p> <p>This entry also includes proteins from fungi and plants [[cite:PUB00077131]]. The plant proteins in this entry, including CAND6 and CAND7, are predicted to be G-protein coupled receptors [[cite:PUB00093391]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016021
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Subterm of

Associated Lotus transcripts 27

Transcript Name Description Predicted domains Domain count
Lj0g3v0214579.1
– PREDICTED: protein GPR107-like [Cicer arietinum] gi|502110573|ref|XP_004493910.1|
Domains
8
Lj0g3v0274109.1
– PREDICTED: transmembrane protein 87A-like isoform X1 [Cicer arietinum] gi|502095649|ref|XP_004490504.1|
Domains
9
Lj0g3v0362149.1
– Protein GPR107 [Medicago truncatula] gi|357510519|ref|XP_003625548.1|
Domains
8
Lj3g3v0439840.1
– PREDICTED: transmembrane protein 87B-like [Glycine max] gi|356520814|ref|XP_003529055.1|
Domains
14
Lj3g3v2576540.1
– PREDICTED: transmembrane protein 87A-like [Cicer arietinum] gi|502156540|ref|XP_004510525.1|
Domains
16
Lj3g3v2576540.2
– PREDICTED: transmembrane protein 87A-like [Cicer arietinum] gi|502156540|ref|XP_004510525.1|
Domains
15
Lj5g3v0615360.1
– PREDICTED: protein GPR107-like [Cicer arietinum] gi|502114546|ref|XP_004494982.1|
Domains
16
Lj6g3v0227580.1
– PREDICTED: protein GPR107-like [Cicer arietinum] gi|502134274|ref|XP_004502059.1|
Domains
13
Lj6g3v0227590.1
– PREDICTED: protein GPR107-like [Cicer arietinum] gi|502134274|ref|XP_004502059.1|
Domains
13
Lj6g3v2257820.1
– PREDICTED: transmembrane protein 87A-like [Glycine max] gi|356558534|ref|XP_003547560.1|
Domains
15
LotjaGi1g1v0132100.1
– Transmembrane protein 87A; TAIR: AT1G61670.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q28EW0|TM87A_XENTR Transmembrane protein 87A; TrEMBL-Plants: tr|A0A1J7HRF5|A0A1J7HRF5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0132100
Domains
8
LotjaGi1g1v0132100.2
– Transmembrane protein 87A; TAIR: AT1G61670.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q28EW0|TM87A_XENTR Transmembrane protein 87A; TrEMBL-Plants: tr|A0A1J7HRF5|A0A1J7HRF5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0132100
Domains
9
LotjaGi1g1v0132100.3
– Transmembrane protein 87A; TAIR: AT1G61670.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BKU8|TM87B_MOUSE Transmembrane protein 87B; TrEMBL-Plants: tr|A0A1J7HRF5|A0A1J7HRF5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0132100
Domains
9
LotjaGi1g1v0696300.1
– Lung seven transmembrane receptor family protein; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|V7CX63|V7CX63_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0696300
Domains
15
LotjaGi1g1v0696300.2
– Lung seven transmembrane receptor family protein; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|V7CX63|V7CX63_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0696300
Domains
15
LotjaGi3g1v0051000.1
– Transmembrane protein 87A; TAIR: AT1G61670.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q96K49|TM87B_HUMAN Transmembrane protein 87B; TrEMBL-Plants: tr|K7L1C5|K7L1C5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0051000
Domains
13
LotjaGi3g1v0289400_LC.1
– Lung seven transmembrane receptor family protein; TAIR: AT3G09570.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q5VW38|GP107_HUMAN Protein GPR107; TrEMBL-Plants: tr|G7L0Q1|G7L0Q1_MEDTR Lung seven transmembrane receptor family protein; Found in the gene: LotjaGi3g1v0289400_LC
Domains
12
LotjaGi3g1v0368500.1
– Transmembrane protein, putative; TAIR: AT1G52155.1 transmembrane protein; Swiss-Prot: sp|A6ZZS6|PTM1_YEAS7 Membrane protein PTM1; TrEMBL-Plants: tr|G7LFW9|G7LFW9_MEDTR Transmembrane protein, putative; Found in the gene: LotjaGi3g1v0368500
Domains
7
LotjaGi3g1v0412100.1
– Transmembrane protein 87A; TAIR: AT1G72480.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q28EW0|TM87A_XENTR Transmembrane protein 87A; TrEMBL-Plants: tr|I1MK24|I1MK24_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0412100
Domains
15
LotjaGi3g1v0412100.2
– Transmembrane protein 87A; TAIR: AT1G72480.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q28EW0|TM87A_XENTR Transmembrane protein 87A; TrEMBL-Plants: tr|I1MK24|I1MK24_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0412100
Domains
9
LotjaGi3g1v0412100.3
– Transmembrane protein 87A; TAIR: AT1G72480.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q28EW0|TM87A_XENTR Transmembrane protein 87A; TrEMBL-Plants: tr|I1MK24|I1MK24_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0412100
Domains
15
LotjaGi5g1v0071300.1
– Lung seven transmembrane receptor, putative; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|V7BF79|V7BF79_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0071300
Domains
15
LotjaGi5g1v0071300.2
– Lung seven transmembrane receptor, putative; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|V7BF79|V7BF79_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0071300
Domains
15
LotjaGi5g1v0071300.3
– Lung seven transmembrane receptor, putative; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|V7BF79|V7BF79_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0071300
Domains
15
LotjaGi5g1v0071300.4
– Lung seven transmembrane receptor, putative; TAIR: AT5G18520.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|A0A103XH29|A0A103XH29_CYNCS Transmembrane receptor, eukaryota; Found in the gene: LotjaGi5g1v0071300
Domains
15
LotjaGi6g1v0032700.1
– Lung seven transmembrane receptor family protein; TAIR: AT5G42090.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BUV8|GP107_MOUSE Protein GPR107; TrEMBL-Plants: tr|A0A151R1T1|A0A151R1T1_CAJCA Protein GPR107 family; Found in the gene: LotjaGi6g1v0032700
Domains
13
LotjaGi6g1v0358200.1
– Transmembrane protein 87A; TAIR: AT2G01070.1 Lung seven transmembrane receptor family protein; Swiss-Prot: sp|Q8BKU8|TM87B_MOUSE Transmembrane protein 87B; TrEMBL-Plants: tr|A0A151T806|A0A151T806_CAJCA Transmembrane protein 87B; Found in the gene: LotjaGi6g1v0358200
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 3.70