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IPR000738 is a WHEP-TRS domain.
<p>A conserved domain of 46 amino acids, called WHEP-TRS has been shown [[cite:PUB00001214]] to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl-tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl-tRNA synthetases [[cite:PUB00002829]]. The structure of a human WHEP-TRS domain has been solved and consists of two helices arranged in a helix-turn-helix [[cite:PUB00013215]]. The WHEP-TRS domain may play a role in the association of tRNA-synthetases into multienzyme complexes [[cite:PUB00033807]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminoacyl-tRNA ligase activity | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | TRNA aminoacylation for protein translation | The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glycine--tRNA ligase 1, mitochondrial-like [Cicer arietinum] gi|502127199|ref|XP_004499600.1| | 32 | ||
| – | PREDICTED: asparagine--tRNA ligase, cytoplasmic 1-like [Cicer arietinum] gi|502138744|ref|XP_004503515.1| | 18 | ||
| – | PREDICTED: asparagine--tRNA ligase, cytoplasmic 1-like [Cicer arietinum] gi|502138744|ref|XP_004503515.1| | 28 | ||
| – | Glycine--tRNA ligase; TAIR: AT1G29880.1 glycyl-tRNA synthetase / glycine-tRNA ligase; Swiss-Prot: sp|O23627|SYGM1_ARATH Glycine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A072U6L4|A0A072U6L4_MEDTR Glycyl-tRNA synthetase/glycine-tRNA ligase; Found in the gene: LotjaGi1g1v0551900 | 35 | ||
| – | Asparagine--tRNA ligase; TAIR: AT5G56680.1 Class II aminoacyl-tRNA and biotin synthetases superfamily protein; Swiss-Prot: sp|Q9SW96|SYNC1_ARATH Asparagine--tRNA ligase, cytoplasmic 1; TrEMBL-Plants: tr|V7CQ72|V7CQ72_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0442400 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04318 | CDD | 1 | 20.00 |