Description

IPR000922 is a D-galactoside/L-rhamnose binding SUEL lectin domain.

<p>The D-galactoside binding lectin purified from sea urchin (Anthocidaris crassispina) eggs exists as a disulphide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity [[cite:PUB00006605]]. The sea urchin egg lectin (SUEL) forms a new class of lectins. Although SUEL was first isolated as a D-galactoside binding lectin, it was latter shown that it binds to L-rhamnose preferentially [[cite:PUB00006605], [cite:PUB00006606]]. L-rhamnose and D-galactose share the same hydroxyl group orientation at C2 and C4 of the pyranose ring structure.</p> <p>A cysteine-rich domain homologous to the SUEL protein has been identified in the following proteins [[cite:PUB00006607], [cite:PUB00006608], [cite:PUB00005840]]:</p> <ul><li>Plant beta-galactosidases ([ec:3.2.1.23]) (lactases).</li> <li>Mammalian latrophilin, the calcium independent receptor of alpha-latrotoxin (CIRL). The galactose-binding lectin domain is not required for alpha-latratoxin binding [[cite:PUB00005840]].</li> <li>Human lectomedin-1.</li> <li>Rhamnose-binding lectin (SAL) from catfish (Silurus asotus, Namazu) eggs. This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each domain are completely conserved [[cite:PUB00006606]].</li> <li>The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans.</li> <li>The human KIAA0821 protein.</li></ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 46

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: