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IPR001305

Source: InterPro

Description

IPR001305 is a Heat shock protein DnaJ, cysteine-rich domain.

<p>The hsp70 chaperone machine performs many diverse roles in the cell, including folding of nascent proteins, translocation of polypeptides across organelle membranes, coordinating responses to stress, and targeting selected proteins for degradation. DnaJ is a member of the hsp40 family of molecular chaperones, which is also called the J-protein family, the members of which regulate the activity of hsp70s. DnaJ (hsp40) binds to DnaK (hsp70) and stimulates its ATPase activity, generating the ADP-bound state of DnaK, which interacts stably with the polypeptide substrate [[cite:PUB00033831]]. Besides stimulating the ATPase activity of DnaK through its J-domain, DnaJ also associates with unfolded polypeptide chains and prevents their aggregation [[cite:PUB00014967]].</p> <p>DnaJ consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acid residues, a glycine and phenylalanine-rich domain ('G/F' domain), a central cysteine rich domain (CR-type zinc finger) containing four repeats of a CXXCXGXG motif which can coordinate two zinc atom and a C-terminal domain (CTD) [[cite:PUB00020790]].</p> <p>This entry represents the central cysteine-rich (CR) domain of DnaJ proteins. This central cysteine rich domain (CR-type zinc finger) has an overall V-shaped extended β-hairpin topology and contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DnaJ cysteine rich domain and various hydrophobic peptides has been found [[cite:PUB00019436]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0031072
Molecular function Heat shock protein binding Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
Subterm of
GO:0051082
Molecular function Unfolded protein binding Interacting selectively and non-covalently with an unfolded protein.
Subterm of

Associated Lotus transcripts 49

Transcript Name Description Predicted domains Domain count
Lj0g3v0074139.1
– Chaperone protein dnaJ-related protein [Arabidopsis thaliana] gi|30682394|ref|NP_850052.1|
Domains
5
Lj0g3v0107479.1
– PREDICTED: chaperone protein dnaJ 1, mitochondrial-like [Glycine max] gi|356542391|ref|XP_003539650.1|
Domains
7
Lj0g3v0267619.3
– PREDICTED: chaperone protein DnaJ-like [Glycine max] gi|356522869|ref|XP_003530065.1|
Domains
32
Lj0g3v0267619.4
– PREDICTED: chaperone protein DnaJ-like [Glycine max] gi|356522869|ref|XP_003530065.1|
Domains
18
Lj0g3v0271799.1
– DnaJ/Hsp40 cysteine-rich domain superfamily protein [Theobroma cacao] gi|508782037|gb|EOY29293.1|
Domains
4
Lj0g3v0345969.1
– PREDICTED: chaperone protein DnaJ-like [Glycine max] gi|356525463|ref|XP_003531344.1|
Domains
8
Lj1g3v0246820.1
– PREDICTED: chaperone protein dnaJ 1, mitochondrial-like isoform X2 [Cicer arietinum] gi|502095201|ref|XP_004490397.1|
Domains
26
Lj1g3v0246820.2
– PREDICTED: chaperone protein dnaJ 1, mitochondrial-like isoform X3 [Cicer arietinum] gi|502095205|ref|XP_004490398.1|
Domains
26
Lj1g3v1911740.2
– DnaJ/Hsp40 cysteine-rich domain superfamily protein isoform 3, partial [Theobroma cacao] gi|508782240|gb|EOY29496.1|
Domains
5
Lj1g3v3980450.1
– DnaJ/Hsp40 cysteine-rich domain superfamily protein isoform 1 [Theobroma cacao] gi|508718558|gb|EOY10455.1|
Domains
5
Lj3g3v0044290.1
– PREDICTED: chaperone protein DnaJ-like isoform X1 [Cicer arietinum] gi|502080714|ref|XP_004486655.1|
Domains
34
Lj3g3v0509890.1
– PREDICTED: chaperone protein dnaJ 2-like [Glycine max] gi|356504601|ref|XP_003521084.1|
Domains
24
Lj3g3v0881630.1
– PREDICTED: chaperone protein dnaJ 1, mitochondrial-like [Glycine max] gi|356542391|ref|XP_003539650.1|
Domains
25
Lj3g3v1295690.1
– Seed maturation protein PM37 [Glycine max] gi|351724545|ref|NP_001238341.1|
Domains
15
Lj3g3v1295700.1
–
Domains
15
Lj3g3v2927370.1
– Seed maturation protein PM37 [Glycine max] gi|351724545|ref|NP_001238341.1|
Domains
14
Lj3g3v2927380.1
– Seed maturation protein PM37 [Glycine max] gi|351724545|ref|NP_001238341.1|
Domains
14
Lj3g3v2927380.2
– Seed maturation protein PM37 [Glycine max] gi|351724545|ref|NP_001238341.1|
Domains
12
Lj4g3v0216660.1
– PREDICTED: LOW QUALITY PROTEIN: urease accessory protein UreF-like [Cicer arietinum] gi|502098316|ref|XP_004491206.1|
Domains
3
Lj4g3v1845710.1
– Plastid transcriptionally active 5 isoform 1 [Theobroma cacao] gi|508783723|gb|EOY30979.1|
Domains
8
Lj4g3v1879170.1
– DnaJ/Hsp40 cysteine-rich domain superfamily protein isoform 1 [Theobroma cacao] gi|508783806|gb|EOY31062.1|
Domains
6
Lj4g3v1879170.2
– DnaJ/Hsp40 cysteine-rich domain superfamily protein isoform 1 [Theobroma cacao] gi|508783806|gb|EOY31062.1|
Domains
6
Lj5g3v0175610.1
– PREDICTED: protein disulfide-isomerase LQY1-like [Cicer arietinum] gi|502126271|ref|XP_004499244.1|
Domains
9
Lj5g3v0962370.1
– Protein plastid transcriptionally active 5 [Arabidopsis thaliana] gi|30682566|ref|NP_193103.2|
Domains
15
Lj5g3v2292530.1
– DnaJ/Hsp40 cysteine-rich domain superfamily protein [Theobroma cacao] gi|508785145|gb|EOY32401.1|
Domains
5
Lj5g3v2292530.3
– DnaJ/Hsp40 cysteine-rich domain superfamily protein [Theobroma cacao] gi|508785145|gb|EOY32401.1|
Domains
5
LotjaGi1g1v0140500.1
– Chaperone protein DNAj, putative; TAIR: AT1G28210.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7K9W1|K7K9W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500
Domains
25
LotjaGi1g1v0140500.2
– Chaperone protein DNAj, putative; TAIR: AT1G28210.2 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7K9W1|K7K9W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500
Domains
31
LotjaGi1g1v0140500.3
– Chaperone protein DNAj, putative; TAIR: AT1G28210.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7M7R2|K7M7R2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500
Domains
28
LotjaGi2g1v0114200.1
– Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200
Domains
29
LotjaGi2g1v0114200.2
– Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200
Domains
29
LotjaGi2g1v0114200.3
– Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200
Domains
29
LotjaGi2g1v0193500.1
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193500
Domains
15
LotjaGi2g1v0194000.1
– Chaperone protein DnaJ; TAIR: AT3G17830.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|I1KJ68|I1KJ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0194000
Domains
30
LotjaGi2g1v0194000.2
– Chaperone protein DnaJ; TAIR: AT3G17830.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|I1KJ68|I1KJ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0194000
Domains
34
LotjaGi3g1v0008000.1
– Chaperone protein dnaJ; TAIR: AT1G80030.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|A0A0B2SH79|A0A0B2SH79_GLYSO Chaperone protein DnaJ; Found in the gene: LotjaGi3g1v0008000
Domains
36
LotjaGi3g1v0058000.1
– Chaperone protein DNAj, putative; TAIR: AT5G48030.1 gametophytic factor 2; Swiss-Prot: sp|Q8GWW8|GFA2_ARATH Chaperone protein dnaJ GFA2, mitochondrial; TrEMBL-Plants: tr|A0A151RE69|A0A151RE69_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0058000
Domains
29
LotjaGi3g1v0063600.1
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1JMV0|I1JMV0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600
Domains
29
LotjaGi3g1v0063600.2
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1KJN5|I1KJN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600
Domains
29
LotjaGi3g1v0063600.3
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1JMV0|I1JMV0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600
Domains
29
LotjaGi3g1v0124500.1
– Chaperone protein DNAj, putative; TAIR: AT5G48030.1 gametophytic factor 2; Swiss-Prot: sp|Q8GWW8|GFA2_ARATH Chaperone protein dnaJ GFA2, mitochondrial; TrEMBL-Plants: tr|A0A0L9UJX2|A0A0L9UJX2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0124500
Domains
30
LotjaGi3g1v0184100.1
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100
Domains
29
LotjaGi3g1v0184100.2
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100
Domains
29
LotjaGi3g1v0184100.3
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2VJQ1|A0A0D2VJQ1_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100
Domains
29
LotjaGi3g1v0470700.1
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0470700
Domains
30
LotjaGi3g1v0470700.2
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A151R8Y4|A0A151R8Y4_CAJCA DnaJ protein isogeny ANJ1; Found in the gene: LotjaGi3g1v0470700
Domains
30
LotjaGi3g1v0470700.3
– Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A151R8Y4|A0A151R8Y4_CAJCA DnaJ protein isogeny ANJ1; Found in the gene: LotjaGi3g1v0470700
Domains
30
LotjaGi6g1v0093000_LC.1
– Chaperone protein DnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0093000_LC
Domains
10
LotjaGi6g1v0093400.1
– Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|A0A151S382|A0A151S382_CAJCA Chaperone protein dnaJ; Found in the gene: LotjaGi6g1v0093400
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd10747 CDD 1 2.04