Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR036410 is a Heat shock protein DnaJ, cysteine-rich domain superfamily.
<p>The hsp70 chaperone machine performs many diverse roles in the cell, including folding of nascent proteins, translocation of polypeptides across organelle membranes, coordinating responses to stress, and targeting selected proteins for degradation. DnaJ is a member of the hsp40 family of molecular chaperones, which is also called the J-protein family, the members of which regulate the activity of hsp70s. DnaJ (hsp40) binds to DnaK (hsp70) and stimulates its ATPase activity, generating the ADP-bound state of DnaK, which interacts stably with the polypeptide substrate [[cite:PUB00033831]]. Besides stimulating the ATPase activity of DnaK through its J-domain, DnaJ also associates with unfolded polypeptide chains and prevents their aggregation [[cite:PUB00014967]].</p> <p>DnaJ consists of an N-terminal conserved domain (called 'J' domain) of about 70 amino acid residues, a glycine and phenylalanine-rich domain ('G/F' domain), a central cysteine rich domain (CR-type zinc finger) containing four repeats of a CXXCXGXG motif which can coordinate two zinc atom and a C-terminal domain (CTD) [[cite:PUB00020790]].</p> <p>This entry represents the central cysteine-rich (CR) domain of DnaJ proteins. This central cysteine rich domain (CR-type zinc finger) has an overall V-shaped extended β-hairpin topology and contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DnaJ cysteine rich domain and various hydrophobic peptides has been found [[cite:PUB00019436]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Chaperone protein dnaJ-like; TAIR: AT3G17668.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q8GSJ6|LQY1_ARATH Protein disulfide-isomerase LQY1, chloroplastic; TrEMBL-Plants: tr|K7KB52|K7KB52_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0054200 | 4 | ||
| – | Chaperone DnaJ; TAIR: AT5G02160.1 transmembrane protein; Swiss-Prot: sp|P47265|DNAJ_MYCGE Chaperone protein DnaJ; TrEMBL-Plants: tr|I3SFD1|I3SFD1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0087600 | 7 | ||
| – | Chaperone protein DNAj, putative; TAIR: AT1G28210.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7K9W1|K7K9W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500 | 25 | ||
| – | Chaperone protein DNAj, putative; TAIR: AT1G28210.2 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7K9W1|K7K9W1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500 | 31 | ||
| – | Chaperone protein DNAj, putative; TAIR: AT1G28210.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q38813|DNAJ1_ARATH Chaperone protein dnaJ 1, mitochondrial; TrEMBL-Plants: tr|K7M7R2|K7M7R2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0140500 | 28 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G24860.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q8GSJ6|LQY1_ARATH Protein disulfide-isomerase LQY1, chloroplastic; TrEMBL-Plants: tr|I1K8L3|I1K8L3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0375700 | 4 | ||
| – | Chaperone DnaJ; TAIR: AT3G47650.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|A6WX07|DNAJ_OCHA4 Chaperone protein DnaJ; TrEMBL-Plants: tr|I3SGK9|I3SGK9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0384300 | 4 | ||
| – | Chaperone protein dnaJ-like protein; TAIR: AT2G24395.1 chaperone protein dnaJ-like protein; Swiss-Prot: sp|Q9RDD7|DNAJ2_STRCO Chaperone protein DnaJ 2; TrEMBL-Plants: tr|V7AY57|V7AY57_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0397500 | 2 | ||
| – | Chaperone protein DnaJ; TAIR: AT5G17840.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q73Q15|DNAJ_TREDE Chaperone protein DnaJ; TrEMBL-Plants: tr|I3SWM8|I3SWM8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0648600 | 4 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200 | 29 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200 | 29 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0114200 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193500 | 15 | ||
| – | Chaperone protein DnaJ; TAIR: AT3G17830.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|I1KJ68|I1KJ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0194000 | 30 | ||
| – | Chaperone protein DnaJ; TAIR: AT3G17830.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|I1KJ68|I1KJ68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0194000 | 34 | ||
| – | Chaperone protein dnaJ; TAIR: AT1G80030.1 Molecular chaperone Hsp40/DnaJ family protein; Swiss-Prot: sp|Q8DKR7|DNAJ_THEEB Chaperone protein DnaJ; TrEMBL-Plants: tr|A0A0B2SH79|A0A0B2SH79_GLYSO Chaperone protein DnaJ; Found in the gene: LotjaGi3g1v0008000 | 36 | ||
| – | Chaperone protein DNAj, putative; TAIR: AT5G48030.1 gametophytic factor 2; Swiss-Prot: sp|Q8GWW8|GFA2_ARATH Chaperone protein dnaJ GFA2, mitochondrial; TrEMBL-Plants: tr|A0A151RE69|A0A151RE69_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0058000 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1JMV0|I1JMV0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1KJN5|I1KJN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P42825|DNAJ2_ARATH Chaperone protein dnaJ 2; TrEMBL-Plants: tr|I1JMV0|I1JMV0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0063600 | 29 | ||
| – | Chaperone protein DNAj, putative; TAIR: AT5G48030.1 gametophytic factor 2; Swiss-Prot: sp|Q8GWW8|GFA2_ARATH Chaperone protein dnaJ GFA2, mitochondrial; TrEMBL-Plants: tr|A0A0L9UJX2|A0A0L9UJX2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0124500 | 30 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|P43644|DNJH_ATRNU DnaJ protein homolog ANJ1; TrEMBL-Plants: tr|A0A0D2VJQ1|A0A0D2VJQ1_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0184100 | 29 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A0D2PQJ2|A0A0D2PQJ2_GOSRA Uncharacterized protein; Found in the gene: LotjaGi3g1v0470700 | 30 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A151R8Y4|A0A151R8Y4_CAJCA DnaJ protein isogeny ANJ1; Found in the gene: LotjaGi3g1v0470700 | 30 | ||
| – | Chaperone protein dnaJ, putative; TAIR: AT5G22060.1 DNAJ homologue 2; Swiss-Prot: sp|Q04960|DNJH_CUCSA DnaJ protein homolog; TrEMBL-Plants: tr|A0A151R8Y4|A0A151R8Y4_CAJCA DnaJ protein isogeny ANJ1; Found in the gene: LotjaGi3g1v0470700 | 30 | ||
| – | Chaperone DnaJ; TAIR: AT3G45050.2 transmembrane protein; Swiss-Prot: sp|Q8DI39|UVRC_THEEB UvrABC system protein C; TrEMBL-Plants: tr|C6TFV3|C6TFV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0487500 | 6 | ||
| – | Chaperone protein DnaJ; TAIR: AT1G75125.1 plastid transcriptionally active protein; Swiss-Prot: sp|Q8C3L1|SSUH2_MOUSE Protein SSUH2 homolog; TrEMBL-Plants: tr|I3T872|I3T872_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0268000 | 8 | ||
| – | Chaperone DnaJ; TAIR: AT3G47650.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q5UP23|YR260_MIMIV DnaJ-like protein R260; TrEMBL-Plants: tr|I3T896|I3T896_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0270500 | 5 | ||
| – | Chaperone protein dnaJ; TAIR: AT1G75690.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q8GSJ6|LQY1_ARATH Protein disulfide-isomerase LQY1, chloroplastic; TrEMBL-Plants: tr|I3S1G6|I3S1G6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0006900 | 9 | ||
| – | Chaperone protein dnaJ; TAIR: AT1G75690.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|Q8GSJ6|LQY1_ARATH Protein disulfide-isomerase LQY1, chloroplastic; TrEMBL-Plants: tr|I3S1G6|I3S1G6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0006900 | 8 | ||
| – | Chaperone protein dnaJ-like protein; TAIR: AT4G13670.1 plastid transcriptionally active 5; Swiss-Prot: sp|L7N653|CWLM_MYCTU N-acetylmuramoyl-L-alanine amidase CwlM; TrEMBL-Plants: tr|K7N4K1|K7N4K1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0163300 | 16 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G34860.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein; Swiss-Prot: sp|O64750|EDA3_ARATH Protein EMBRYO SAC DEVELOPMENT ARREST 3, chloroplastic; TrEMBL-Plants: tr|I3SKJ0|I3SKJ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0361100 | 4 | ||
| – | Chaperone protein DnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|I1KT02|I1KT02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0093000_LC | 10 | ||
| – | Chaperone protein dnaJ; TAIR: AT2G22360.1 DNAJ heat shock family protein; Swiss-Prot: sp|Q9SJZ7|DNJA6_ARATH Chaperone protein dnaJ A6, chloroplastic; TrEMBL-Plants: tr|A0A151S382|A0A151S382_CAJCA Chaperone protein dnaJ; Found in the gene: LotjaGi6g1v0093400 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd10747 | CDD | 1 | 2.78 |