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IPR005142 is a eRF1 domain 3.
<p>This domain is found in the release factor eRF1 which terminates protein biosynthesis by recognizing stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [[cite:PUB00007747]]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [[cite:PUB00007747]].</p> <p>This domain is also found in other proteins which may also be involved in translation termination but this awaits experimental verification.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: eukaryotic peptide chain release factor subunit 1-3-like [Glycine max] gi|356560043|ref|XP_003548305.1| | 10 | ||
| – | PREDICTED: eukaryotic peptide chain release factor subunit 1-3 [Vitis vinifera] gi|225460446|ref|XP_002271656.1| | 19 | ||
| – | PREDICTED: eukaryotic peptide chain release factor subunit 1-3-like [Cicer arietinum] gi|502106984|ref|XP_004493119.1| | 19 | ||
| – | Pelota-like protein [Medicago truncatula] gi|357510895|ref|XP_003625736.1| | 13 | ||
| – | PREDICTED: eukaryotic peptide chain release factor subunit 1-3-like [Glycine max] gi|356531058|ref|XP_003534095.1| | 19 | ||
| – | PREDICTED: protein pelota-like [Glycine max] gi|356535240|ref|XP_003536156.1| | 15 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I3T2R1|I3T2R1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0637500 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I3T2R1|I3T2R1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0637500 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I3T2R1|I3T2R1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0637500 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I3T2R1|I3T2R1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0637500 | 20 | ||
| – | Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|G7L4Y7|G7L4Y7_MEDTR Eukaryotic release factor 1 (ERF1) family protein; Found in the gene: LotjaGi1g1v0683200 | 18 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I1L3W8|I1L3W8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0182000 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|I1L3W8|I1L3W8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0182000 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|A0A0R0I9D1|A0A0R0I9D1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0182000 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT1G12920.1 eukaryotic release factor 1-2; Swiss-Prot: sp|Q9LPV8|ERF1Y_ARATH Eukaryotic peptide chain release factor subunit 1-2; TrEMBL-Plants: tr|F6I3Y5|F6I3Y5_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0218100 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|A0A0L9VIQ2|A0A0L9VIQ2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015400 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|A0A0L9VIQ2|A0A0L9VIQ2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015400 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|A0A0L9VIQ2|A0A0L9VIQ2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015400 | 20 | ||
| – | Eukaryotic peptide chain release factor subunit 1-1; TAIR: AT3G26618.1 eukaryotic release factor 1-3; Swiss-Prot: sp|P35614|ERF1Z_ARATH Eukaryotic peptide chain release factor subunit 1-3; TrEMBL-Plants: tr|A0A0L9VIQ2|A0A0L9VIQ2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015400 | 20 | ||
| – | Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|V7BDS6|V7BDS6_PHAVU Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100 | 19 | ||
| – | Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100 | 19 | ||
| – | Protein pelota homolog; TAIR: AT4G27650.1 Eukaryotic release factor 1 (eRF1) family protein; Swiss-Prot: sp|Q9ZT87|PEL1_ARATH Protein PELOTA 1; TrEMBL-Plants: tr|A0A151U5G2|A0A151U5G2_CAJCA Protein pelota homolog; Found in the gene: LotjaGi5g1v0204100 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00111 | TIGRFAM | 1 | 4.55 |