Description

IPR006408 is a P-type ATPase, subfamily IIB.

<p>This family describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes [[cite:PUB00009617]], out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes [[cite:PUB00009618]]. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects [[cite:PUB00009619]]. The calcium P-type ATPases have been characterised as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump [[cite:PUB00009616]].</p> <p>P-ATPases (also known as E1-E2 ATPases) ([ec:3.6.3.-]) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [[cite:PUB00009616]]. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H⁺, Na⁺, K⁺, Mg²⁺, Ca²⁺, Ag⁺and Ag²⁺, Zn²⁺, Co²⁺, Pb²⁺, Ni²⁺, Cd²⁺, Cu⁺and Cu²⁺. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.</p> <p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 50

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: