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IPR006639 is a Presenilin/signal peptide peptidase.
<p>Presenilin 1 (PSN1) and presenilin 2 (PSN2) are membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. They undergo tightly regulated endolytic processing to generate stable PSN C-terminal and N-terminal fragments that form the catalytic core of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors [[cite:PUB00066713]].</p> <p>Presenelins are related to the signal peptide peptidase (SPP) family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides. However, the SPPs work as single polypeptides. SPP catalyses intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. In humans, SPP activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognised by the immune system, and are required in the processing of the hepatitis C virus core protein [[cite:PUB00020020], [cite:PUB00066714]].</p> <p>This group of aspartic peptidases belong to MEROPS peptidase family A22 (presenilin family, clan AD).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: signal peptide peptidase-like 2B-like [Glycine max] gi|356568398|ref|XP_003552398.1| | 20 | ||
| – | PREDICTED: presenilin-like protein At1g08700-like [Cicer arietinum] gi|502107407|ref|XP_004493253.1| | 13 | ||
| – | PREDICTED: signal peptide peptidase-like 2B-like [Glycine max] gi|356497238|ref|XP_003517469.1| | 20 | ||
| – | PREDICTED: signal peptide peptidase-like [Cicer arietinum] gi|502131994|ref|XP_004501187.1| | 9 | ||
| – | PREDICTED: signal peptide peptidase-like 2B-like [Glycine max] gi|356527443|ref|XP_003532320.1| | 21 | ||
| – | PREDICTED: signal peptide peptidase-like 4-like isoform X1 [Cicer arietinum] gi|502157171|ref|XP_004510782.1| | 20 | ||
| – | PREDICTED: presenilin-like protein At2g29900-like [Cicer arietinum] gi|502151907|ref|XP_004508672.1| | 12 | ||
| – | PREDICTED: signal peptide peptidase-like 3-like [Glycine max] gi|356575974|ref|XP_003556110.1| | 10 | ||
| – | PREDICTED: signal peptide peptidase-like 5-like isoform X1 [Cicer arietinum] gi|502121709|ref|XP_004497418.1| | 21 | ||
| – | PREDICTED: signal peptide peptidase-like 5-like isoform X1 [Cicer arietinum] gi|502121709|ref|XP_004497418.1| | 10 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G03120.1 signal peptide peptidase; Swiss-Prot: sp|O81062|SIP_ARATH Signal peptide peptidase; TrEMBL-Plants: tr|I3S2E3|I3S2E3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0399600 | 11 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G03120.1 signal peptide peptidase; Swiss-Prot: sp|O81062|SIP_ARATH Signal peptide peptidase; TrEMBL-Plants: tr|I3T5V7|I3T5V7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0399600 | 11 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G03120.1 signal peptide peptidase; Swiss-Prot: sp|O81062|SIP_ARATH Signal peptide peptidase; TrEMBL-Plants: tr|I3T5V7|I3T5V7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0399600 | 11 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G03120.1 signal peptide peptidase; Swiss-Prot: sp|O81062|SIP_ARATH Signal peptide peptidase; TrEMBL-Plants: tr|I3S2E3|I3S2E3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0399600 | 15 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G03120.1 signal peptide peptidase; Swiss-Prot: sp|O81062|SIP_ARATH Signal peptide peptidase; TrEMBL-Plants: tr|I3S2E3|I3S2E3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0399600 | 11 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G01650.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 4; Swiss-Prot: sp|Q0WMJ8|SIPL4_ARATH Signal peptide peptidase-like 4; TrEMBL-Plants: tr|A0A0B2NQL8|A0A0B2NQL8_GLYSO Signal peptide peptidase-like 2B; Found in the gene: LotjaGi1g1v0477200 | 19 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G05820.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 5; Swiss-Prot: sp|Q9MA44|SIPL5_ARATH Signal peptide peptidase-like 5; TrEMBL-Plants: tr|V7AZT9|V7AZT9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0554700 | 20 | ||
| – | Presenilin; TAIR: AT1G08700.1 Presenilin-1; Swiss-Prot: sp|O64668|PSNA_ARATH Presenilin-like protein At1g08700; TrEMBL-Plants: tr|A0A1J7GS47|A0A1J7GS47_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0651100 | 15 | ||
| – | Presenilin; TAIR: AT1G08700.1 Presenilin-1; Swiss-Prot: sp|O64668|PSNA_ARATH Presenilin-like protein At1g08700; TrEMBL-Plants: tr|A0A1J7GS47|A0A1J7GS47_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0651100 | 15 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G63690.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 2; Swiss-Prot: sp|Q8W469|SIPL2_ARATH Signal peptide peptidase-like 2; TrEMBL-Plants: tr|A0A0B2QVP2|A0A0B2QVP2_GLYSO Signal peptide peptidase-like 2B; Found in the gene: LotjaGi2g1v0158900 | 20 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G01650.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 4; Swiss-Prot: sp|Q0WMJ8|SIPL4_ARATH Signal peptide peptidase-like 4; TrEMBL-Plants: tr|G7LBR2|G7LBR2_MEDTR Signal peptide peptidase-like protein; Found in the gene: LotjaGi3g1v0384000 | 20 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G01650.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 4; Swiss-Prot: sp|Q0WMJ8|SIPL4_ARATH Signal peptide peptidase-like 4; TrEMBL-Plants: tr|I1KI95|I1KI95_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0384000 | 15 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G01650.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 4; Swiss-Prot: sp|Q0WMJ8|SIPL4_ARATH Signal peptide peptidase-like 4; TrEMBL-Plants: tr|I1KI95|I1KI95_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0384000 | 15 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT1G63690.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 2; Swiss-Prot: sp|Q8W469|SIPL2_ARATH Signal peptide peptidase-like 2; TrEMBL-Plants: tr|I1JK76|I1JK76_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0384000 | 11 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT4G33410.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 1; Swiss-Prot: sp|Q93Z32|SIPL1_ARATH Signal peptide peptidase-like 1; TrEMBL-Plants: tr|A0A0L9TZP0|A0A0L9TZP0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0299500 | 10 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT4G33410.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 1; Swiss-Prot: sp|Q93Z32|SIPL1_ARATH Signal peptide peptidase-like 1; TrEMBL-Plants: tr|A0A0L9TZP0|A0A0L9TZP0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0299500 | 10 | ||
| – | Signal peptide peptidase-like protein; TAIR: AT2G43070.1 SIGNAL PEPTIDE PEPTIDASE-LIKE 3; Swiss-Prot: sp|Q53P98|SIPL2_ORYSJ Signal peptide peptidase-like 2; TrEMBL-Plants: tr|A0A072VS87|A0A072VS87_MEDTR Signal peptide peptidase-like protein; Found in the gene: LotjaGi5g1v0365200 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 3.70 |