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IPR007642 is a RNA polymerase Rpb2, domain 2.
<p>RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. It is also known as the lobe domain [[cite:PUB00008731]]. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, a region known as dispensable region 1 (DRI).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. | ||
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA polymerase beta subunit [Lotus japonicus] gi|13518436|ref|NP_084796.1| | 12 | ||
| – | PREDICTED: DNA-directed RNA polymerase III subunit RPC2-like [Cicer arietinum] gi|502156666|ref|XP_004510587.1| | 14 | ||
| – | PREDICTED: DNA-directed RNA polymerase D subunit 2a-like [Cicer arietinum] gi|502132489|ref|XP_004501385.1| | 12 | ||
| – | PREDICTED: DNA-directed RNA polymerase I subunit RPA2-like [Glycine max] gi|356548837|ref|XP_003542805.1| | 23 | ||
| – | PREDICTED: DNA-directed RNA polymerase II subunit RPB2-like [Glycine max] gi|356530409|ref|XP_003533774.1| | 19 | ||
| – | RNA polymerase beta subunit [Lotus japonicus] gi|13518436|ref|NP_084796.1| | 12 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT3G23780.1 nuclear RNA polymerase D2A; Swiss-Prot: sp|Q9LK40|NRPD2_ARATH DNA-directed RNA polymerases IV and V subunit 2; TrEMBL-Plants: tr|A0A0B2RBE2|A0A0B2RBE2_GLYSO DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi1g1v0377700 | 29 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT5G45140.1 nuclear RNA polymerase C2; Swiss-Prot: sp|F4KD38|NRPC2_ARATH DNA-directed RNA polymerase III subunit 2; TrEMBL-Plants: tr|K7L1D4|K7L1D4_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi2g1v0391800_LC | 12 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT5G45140.1 nuclear RNA polymerase C2; Swiss-Prot: sp|F4KD38|NRPC2_ARATH DNA-directed RNA polymerase III subunit 2; TrEMBL-Plants: tr|K7L1D4|K7L1D4_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi2g1v0391800_LC | 12 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT5G45140.1 nuclear RNA polymerase C2; Swiss-Prot: sp|F4KD38|NRPC2_ARATH DNA-directed RNA polymerase III subunit 2; TrEMBL-Plants: tr|K7L1D4|K7L1D4_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi2g1v0391800_LC | 12 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT5G45140.3 nuclear RNA polymerase C2; Swiss-Prot: sp|F4KD38|NRPC2_ARATH DNA-directed RNA polymerase III subunit 2; TrEMBL-Plants: tr|A0A1J7GZE0|A0A1J7GZE0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0300900_LC | 11 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT1G29940.1 nuclear RNA polymerase A2; Swiss-Prot: sp|F4I366|NRPA2_ARATH DNA-directed RNA polymerase I subunit 2; TrEMBL-Plants: tr|I1M0N3|I1M0N3_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi3g1v0315900 | 28 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT1G29940.1 nuclear RNA polymerase A2; Swiss-Prot: sp|F4I366|NRPA2_ARATH DNA-directed RNA polymerase I subunit 2; TrEMBL-Plants: tr|A0A0R0GQW5|A0A0R0GQW5_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi3g1v0315900 | 28 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT5G45140.1 nuclear RNA polymerase C2; Swiss-Prot: sp|F4KD38|NRPC2_ARATH DNA-directed RNA polymerase III subunit 2; TrEMBL-Plants: tr|K7L1D3|K7L1D3_SOYBN DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi5g1v0334100 | 30 | ||
| – | DNA-directed RNA polymerase subunit beta; TAIR: AT4G21710.1 DNA-directed RNA polymerase family protein; Swiss-Prot: sp|Q42877|RPB2_SOLLC DNA-directed RNA polymerase II subunit RPB2; TrEMBL-Plants: tr|V7BQ99|V7BQ99_PHAVU DNA-directed RNA polymerase subunit beta; Found in the gene: LotjaGi6g1v0332200 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |