Description

IPR008254 is a Flavodoxin/nitric oxide synthase.

<p>This domain is found in a number of proteins including flavodoxin and nitric-oxide synthase. Flavodoxins are electron-transfer proteins that function in various electron transport systems. They bind one FMN molecule, which serves as a redox-active prosthetic group [[cite:PUB00000480]] and are functionally interchangeable with ferredoxins. They have been isolated from prokaryotes, cyanobacteria, and some eukaryotic algae. Nitric oxide synthase ([ec:1.14.13.39]) produces nitric oxide from L-arginine and NADPH. Nitric oxide acts as a messenger molecule in the body.</p> <p>The flavodoxin-like domain is an around 170-residue domain with a flavin mononucleotide (FMN)-binding site. It is involved in electron transfer reactions [[cite:PUB00018372], [cite:PUB00018374]].</p> <p>Structure analyses of several flavodoxin-like domains have shown that it is a wound α-β-α fold with a central 5-stranded parallel hydrophobic β-sheet flanked on either side by amphipathic α-helices [[cite:PUB00004914], [cite:PUB00018375], [cite:PUB00018376]]. The FMN is positioned at the tip of the C-terminal side of the β-sheet [[cite:PUB00004914]]. The fold correlates with a highly conserved, repetitive sequence pattern in which hydrophobic residues cluster in β-strands and have a 3-4-residue periodicity in α-helices [[cite:PUB00018374]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 60

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: