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IPR013761 is a Sterile alpha motif/pointed domain superfamily.
<p>Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [[cite:PUB00014041]]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed α-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [[cite:PUB00014042]]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.</p> <p>SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [[cite:PUB00014043]]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [[cite:PUB00014044]]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [[cite:PUB00014045]]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [[cite:PUB00014046]]; p73, a p53 homologue involved in neuronal development [[cite:PUB00014047]]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [[cite:PUB00014048]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Thioredoxin superfamily protein [Theobroma cacao] gi|508709654|gb|EOY01551.1| | 6 | ||
| – | Bicaudal C-like protein [Medicago truncatula] gi|357520541|ref|XP_003630559.1| | 10 | ||
| – | PREDICTED: DNA cross-link repair protein SNM1-like [Cicer arietinum] gi|502132540|ref|XP_004501410.1| | 16 | ||
| – | SAM domain family protein [Medicago truncatula] gi|357502717|ref|XP_003621647.1| | 10 | ||
| – | Sterile alpha motif (SAM) domain-containing protein [Arabidopsis thaliana] gi|18399394|ref|NP_566404.1| | 11 | ||
| – | SAM domain family protein [Medicago truncatula] gi|357464317|ref|XP_003602440.1| | 10 | ||
| – | SAM domain family protein [Medicago truncatula] gi|357486169|ref|XP_003613372.1| | 10 | ||
| – | F17A17.10 protein [Theobroma cacao] gi|508701574|gb|EOX93470.1| | 7 | ||
| – | Sterile alpha motif domain-containing protein isoform 1 [Theobroma cacao] gi|508701987|gb|EOX93883.1| | 11 | ||
| – | Sterile alpha motif domain-containing protein isoform 1 [Theobroma cacao] gi|508701987|gb|EOX93883.1| | 11 | ||
| – | Sterile alpha motif domain-containing protein [Theobroma cacao] gi|508778693|gb|EOY25949.1| | 5 | ||
| – | Bicaudal C-like protein [Medicago truncatula] gi|357520541|ref|XP_003630559.1| | 10 | ||
| – | Uncharacterized protein TCM_038226 [Theobroma cacao] gi|508784000|gb|EOY31256.1| | 7 | ||
| – | Bicaudal C-like protein [Medicago truncatula] gi|357520541|ref|XP_003630559.1| | 10 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G07760.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|P18160|SPLA_DICDI Dual specificity protein kinase splA; TrEMBL-Plants: tr|I3S178|I3S178_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0009700 | 7 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G07760.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|P18160|SPLA_DICDI Dual specificity protein kinase splA; TrEMBL-Plants: tr|I3S178|I3S178_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0009700 | 7 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G07760.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|P18160|SPLA_DICDI Dual specificity protein kinase splA; TrEMBL-Plants: tr|I3S178|I3S178_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0009700 | 7 | ||
| – | Mitochondrial import inner membrane translocase subunit TIM22; TAIR: AT5G24650.1 Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein; Swiss-Prot: sp|Q6NKU9|TI223_ARATH Mitochondrial import inner membrane translocase subunit TIM22-3; TrEMBL-Plants: tr|I1JYE9|I1JYE9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0302500 | 10 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G48800.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q9H694|BICC1_HUMAN Protein bicaudal C homolog 1; TrEMBL-Plants: tr|I1JXP2|I1JXP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0334600 | 11 | ||
| – | DNA cross-link repair 1A protein; TAIR: AT2G45700.1 sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q38961|SNM1_ARATH DNA cross-link repair protein SNM1; TrEMBL-Plants: tr|A0A151QYV3|A0A151QYV3_CAJCA DNA cross-link repair 1A protein; Found in the gene: LotjaGi1g1v0372700 | 21 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G48800.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q24009|BICC_DROME Protein bicaudal C; TrEMBL-Plants: tr|I1KWR9|I1KWR9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529300 | 11 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G11890.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q24009|BICC_DROME Protein bicaudal C; TrEMBL-Plants: tr|I1JQD2|I1JQD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0741900 | 11 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT1G70180.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q6NZC7|S23IP_MOUSE SEC23-interacting protein; TrEMBL-Plants: tr|I3S5V0|I3S5V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0314000 | 10 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT1G15760.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|B0K9P4|PNP_THEP3 Polyribonucleotide nucleotidyltransferase; TrEMBL-Plants: tr|A0A0S3SF79|A0A0S3SF79_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006600 | 6 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G07170.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q9Y6Y8|S23IP_HUMAN SEC23-interacting protein; TrEMBL-Plants: tr|I3T340|I3T340_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0085200 | 11 | ||
| – | SAM domain (Sterile alpha motif) protein, putative; TAIR: AT2G12462.1 sterile alpha motif (SAM) domain protein; Swiss-Prot: sp|Q8N9M1|CS047_HUMAN Uncharacterized protein C19orf47; TrEMBL-Plants: tr|A0A0S3R6H4|A0A0S3R6H4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0280900 | 7 | ||
| – | Sterile alpha motif (SAM) domain-containing protein; TAIR: AT3G48800.1 Sterile alpha motif (SAM) domain-containing protein; Swiss-Prot: sp|Q9IA00|BIC1A_XENLA Protein bicaudal C homolog 1-A; TrEMBL-Plants: tr|G7LI38|G7LI38_MEDTR SAM domain protein; Found in the gene: LotjaGi4g1v0420200 | 11 | ||
| – | SAM domain (Sterile alpha motif) protein, putative; TAIR: AT2G12462.1 sterile alpha motif (SAM) domain protein; Swiss-Prot: sp|A0JPQ7|CS047_RAT Uncharacterized protein C19orf47 homolog; TrEMBL-Plants: tr|A0A1J7H6B8|A0A1J7H6B8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0209500 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.57 |