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IPR039429

Description

IPR039429 is a Serine hydroxymethyltransferase-like domain.

<p>Proteins containing this domain include serine hydroxymethyltransferase, alpha-methylserine aldolase and fluorothreonine transaldolase.</p> <p>Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate [[cite:PUB00024584]]. This reaction generates single carbon units for purine, thymidine, and methionine biosynthesis. It belongs to the aspartate aminotransferase superfamily (fold type I) [[cite:PUB00014432]]. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme [[cite:PUB00000663]]. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [[cite:PUB00014432], [cite:PUB00014439]].</p> <p>Fluorothreonine transaldolase catalyzes the final step in 4-fluorothreonine biosynthesis. It mediates a L-threonine/fluoroaceldehyde to 4-fluoro-L-threonine/acetaldehyde crossover reaction. It shares protein sequence similarity with SHMT [[cite:PUB00089683]].</p> <p>Alpha-methylserine aldolase catalyses the reversible interconversion of alpha-methyl-L-serine to L-alanine and formaldehyde [[cite:PUB00155469]]. This enzyme also catalysed alanine racemization.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 20

Transcript Name Description Predicted domains Domain count
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J2Q8|A0A0R4J2Q8_SOYBN Serine hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0134500 17
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J2Q8|A0A0R4J2Q8_SOYBN Serine hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0134500 17
Serine hydroxymethyltransferase; TAIR: AT1G36370.1 serine hydroxymethyltransferase 7; Swiss-Prot: sp|Q84WV0|GLYC7_ARATH Serine hydroxymethyltransferase 7; TrEMBL-Plants: tr|G7J467|G7J467_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0249100 16
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 16
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 16
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 15
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 16
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 15
Serine hydroxymethyltransferase; TAIR: AT4G37930.1 serine transhydroxymethyltransferase 1; Swiss-Prot: sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SY17|I3SY17_LOTJA Serine hydroxymethyltransferase; Found in the gene: LotjaGi2g1v0330200 15
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|A0A1B1RUN9|A0A1B1RUN9_GLYSO Serine hydroxymethyltransferase; Found in the gene: LotjaGi4g1v0371600 16
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|A0A1B1RUN9|A0A1B1RUN9_GLYSO Serine hydroxymethyltransferase; Found in the gene: LotjaGi4g1v0371600 16
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|A0A1B1RUN9|A0A1B1RUN9_GLYSO Serine hydroxymethyltransferase; Found in the gene: LotjaGi4g1v0371600 16
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|G7JAR7|G7JAR7_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0040700 16
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|G7JAR7|G7JAR7_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0040700 16
Serine hydroxymethyltransferase; TAIR: AT4G13930.1 serine hydroxymethyltransferase 4; Swiss-Prot: sp|O23254|GLYC4_ARATH Serine hydroxymethyltransferase 4; TrEMBL-Plants: tr|I3SEQ9|I3SEQ9_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0040700 15
Serine hydroxymethyltransferase; TAIR: AT4G32520.1 serine hydroxymethyltransferase 3; Swiss-Prot: sp|Q94JQ3|GLYP3_ARATH Serine hydroxymethyltransferase 3, chloroplastic; TrEMBL-Plants: tr|V7BSE7|V7BSE7_PHAVU Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0314300 16
Serine hydroxymethyltransferase; TAIR: AT4G32520.1 serine hydroxymethyltransferase 3; Swiss-Prot: sp|Q94JQ3|GLYP3_ARATH Serine hydroxymethyltransferase 3, chloroplastic; TrEMBL-Plants: tr|A0A0R0H289|A0A0R0H289_SOYBN Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0314300 16
Serine hydroxymethyltransferase; TAIR: AT1G22020.1 serine hydroxymethyltransferase 6; Swiss-Prot: sp|Q9LM59|GLYC6_ARATH Serine hydroxymethyltransferase 6; TrEMBL-Plants: tr|G7IPE1|G7IPE1_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0361500 16
Serine hydroxymethyltransferase; TAIR: AT1G22020.1 serine hydroxymethyltransferase 6; Swiss-Prot: sp|Q9LM59|GLYC6_ARATH Serine hydroxymethyltransferase 6; TrEMBL-Plants: tr|G7IPE1|G7IPE1_MEDTR Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0361500 15
Serine hydroxymethyltransferase; TAIR: AT1G22020.1 serine hydroxymethyltransferase 6; Swiss-Prot: sp|Q9LM59|GLYC6_ARATH Serine hydroxymethyltransferase 6; TrEMBL-Plants: tr|A0A0R0IP64|A0A0R0IP64_SOYBN Serine hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0361500 16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 5.00