Description

IPR039429 is a Serine hydroxymethyltransferase-like domain.

<p>Proteins containing this domain include serine hydroxymethyltransferase, alpha-methylserine aldolase and fluorothreonine transaldolase.</p> <p>Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate [[cite:PUB00024584]]. This reaction generates single carbon units for purine, thymidine, and methionine biosynthesis. It belongs to the aspartate aminotransferase superfamily (fold type I) [[cite:PUB00014432]]. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme [[cite:PUB00000663]]. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [[cite:PUB00014432], [cite:PUB00014439]].</p> <p>Fluorothreonine transaldolase catalyzes the final step in 4-fluorothreonine biosynthesis. It mediates a L-threonine/fluoroaceldehyde to 4-fluoro-L-threonine/acetaldehyde crossover reaction. It shares protein sequence similarity with SHMT [[cite:PUB00089683]].</p> <p>Alpha-methylserine aldolase catalyses the reversible interconversion of alpha-methyl-L-serine to L-alanine and formaldehyde [[cite:PUB00155469]]. This enzyme also catalysed alanine racemization.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: