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IPR000308

Description

IPR000308 is a 14-3-3 protein.

<p>The 14-3-3 proteins are a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells [[cite:PUB00003264], [cite:PUB00007085]]. These are structurally similar phospho-binding proteins that regulate multiple signaling pathways [[cite:PUB00097184]]. There is a high degree of sequence identity and conservation between all the 14-3-3 isotypes, particularly in the regions which form the dimer interface or line the central ligand binding channel of the dimeric molecule. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. The monomer consists of nine helices organised in an antiparallel manner, forming an L-shaped structure. The interior of the L-structure is composed of four helices: H3 and H5, which contain many charged and polar amino acids, and H7 and H9, which contain hydrophobic amino acids. These four helices form the concave amphipathic groove that interacts with target peptides.</p> <p>The 14-3-3 proteins mainly bind proteins containing phosphothreonine or phosphoserine motifs, however exceptions to this rule do exist. Extensive investigation of the 14-3-3 binding site of the mammalian serine/threonine kinase Raf-1 has produced a consensus sequence for 14-3-3-binding, RSxpSxP (in the single-letter amino-acid code, where x denotes any amino acid and p indicates that the next residue is phosphorylated). The 14-3-3 proteins appear to effect intracellular signalling in one of three ways - by direct regulation of the catalytic activity of the bound protein, by regulating interactions between the bound protein and other molecules in the cell by sequestration or modification or by controlling the subcellular localisation of the bound ligand. Proteins appear to initially bind to a single dominant site and then subsequently to many, much weaker secondary interaction sites. The 14-3-3 dimer is capable of changing the conformation of its bound ligand whilst itself undergoing minimal structural alteration.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 54

Transcript Name Description Predicted domains Domain count
PREDICTED: 14-3-3-like protein-like [Glycine max] gi|356515770|ref|XP_003526571.1| 9
14-3-3-like protein [Pisum sativum] gi|4850247|emb|CAB42546.2| 13
14-3-3-like protein [Pisum sativum] gi|4850247|emb|CAB42546.2| 10
14-3-3-like protein [Pisum sativum] gi|4850247|emb|CAB42546.2| 10
PREDICTED: 14-3-3-like protein B-like [Cicer arietinum] gi|502133015|ref|XP_004501620.1| 12
PREDICTED: 14-3-3-like protein-like [Glycine max] gi|356515770|ref|XP_003526571.1| 14
PREDICTED: 14-3-3-like protein A-like [Cicer arietinum] gi|502090111|ref|XP_004489124.1| 14
14-3-3 protein SGF14f [Glycine max] gi|351726463|ref|NP_001238407.1| 15
PREDICTED: 14-3-3-like protein D-like [Cicer arietinum] gi|502089828|ref|XP_004489032.1| 11
13
14-3-3 protein SGF14n [Glycine max] gi|351724401|ref|NP_001238592.1| 11
14-3-3 protein SGF14e [Glycine max] gi|351726936|ref|NP_001238423.1| 15
PREDICTED: 14-3-3-like protein GF14 iota-like [Cicer arietinum] gi|502143504|ref|XP_004505365.1| 14
PREDICTED: 14-3-3-like protein C-like [Glycine max] gi|356525282|ref|XP_003531255.1| 15
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I3S5Q3|I3S5Q3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0142400 15
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I3S5Q3|I3S5Q3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0142400 15
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P42653|1433A_VICFA 14-3-3-like protein A; TrEMBL-Plants: tr|I3S5Q3|I3S5Q3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0142400 15
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P42653|1433A_VICFA 14-3-3-like protein A; TrEMBL-Plants: tr|I3S5Q3|I3S5Q3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0142400 14
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I1K9V8|I1K9V8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0339500 15
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I1K9V9|I1K9V9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0339500 14
14-3-3-like family protein; TAIR: AT5G10450.1 G-box regulating factor 6; Swiss-Prot: sp|Q96451|1433B_SOYBN 14-3-3-like protein B; TrEMBL-Plants: tr|B7FK19|B7FK19_MEDTR Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0348500 15
14-3-3 protein; TAIR: AT5G10450.4 G-box regulating factor 6; Swiss-Prot: sp|Q96451|1433B_SOYBN 14-3-3-like protein B; TrEMBL-Plants: tr|G7J567|G7J567_MEDTR General regulatory factor 2; Found in the gene: LotjaGi1g1v0348500 14
14-3-3 protein; TAIR: AT5G10450.2 G-box regulating factor 6; Swiss-Prot: sp|Q96451|1433B_SOYBN 14-3-3-like protein B; TrEMBL-Plants: tr|G7J567|G7J567_MEDTR General regulatory factor 2; Found in the gene: LotjaGi1g1v0348500 14
14-3-3 protein; TAIR: AT4G09000.1 general regulatory factor 1; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|A0A0R0GRY6|A0A0R0GRY6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0442100_LC 10
14-3-3-like protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I3S2P9|I3S2P9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0542300 14
14-3-3 protein; TAIR: AT1G78300.1 general regulatory factor 2; Swiss-Prot: sp|P46266|1433_PEA 14-3-3-like protein; TrEMBL-Plants: tr|I3S2P9|I3S2P9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0542400 15
14-3-3 family protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|P42652|14334_SOLLC 14-3-3 protein 4; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 15
14-3-3 protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|Q9SP07|1433_LILLO 14-3-3-like protein; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|Q9SP07|1433_LILLO 14-3-3-like protein; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|O49997|1433E_TOBAC 14-3-3-like protein E; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|Q9SP07|1433_LILLO 14-3-3-like protein; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 family protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|Q9SP07|1433_LILLO 14-3-3-like protein; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 protein; TAIR: AT3G02520.1 general regulatory factor 7; Swiss-Prot: sp|Q9SP07|1433_LILLO 14-3-3-like protein; TrEMBL-Plants: tr|I3T321|I3T321_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0551800 14
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|A0A0S3T2T3|A0A0S3T2T3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0295600 16
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|E9KNA7|E9KNA7_SOYBN SGF14e; Found in the gene: LotjaGi2g1v0295600 15
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|E9KNA7|E9KNA7_SOYBN SGF14e; Found in the gene: LotjaGi2g1v0295600 15
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|E9KNA7|E9KNA7_SOYBN SGF14e; Found in the gene: LotjaGi2g1v0295600 15
14-3-3-like protein; TAIR: AT1G34760.1 general regulatory factor 11; Swiss-Prot: sp|Q84J55|14331_ORYSJ 14-3-3-like protein GF14-A; TrEMBL-Plants: tr|A0A0K9RR93|A0A0K9RR93_SPIOL Uncharacterized protein; Found in the gene: LotjaGi2g1v0295600 13
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|E9KNA7|E9KNA7_SOYBN SGF14e; Found in the gene: LotjaGi2g1v0295600 15
14-3-3-like protein; TAIR: AT2G42590.2 general regulatory factor 9; Swiss-Prot: sp|Q96453|1433D_SOYBN 14-3-3-like protein D; TrEMBL-Plants: tr|Q9M5K7|Q9M5K7_SOYBN 14-3-3-like protein; Found in the gene: LotjaGi3g1v0158300 13
14-3-3-like protein; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q96453|1433D_SOYBN 14-3-3-like protein D; TrEMBL-Plants: tr|E9KNA3|E9KNA3_SOYBN SGF14n; Found in the gene: LotjaGi3g1v0158300 11
14-3-3-like protein; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q96453|1433D_SOYBN 14-3-3-like protein D; TrEMBL-Plants: tr|E9KNA3|E9KNA3_SOYBN SGF14n; Found in the gene: LotjaGi3g1v0158300 11
14-3-3 protein-like protein; TAIR: AT2G42590.2 general regulatory factor 9; Swiss-Prot: sp|P42654|1433B_VICFA 14-3-3-like protein B; TrEMBL-Plants: tr|I3SI06|I3SI06_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0450800 16
14-3-3 protein-like protein; TAIR: AT2G42590.2 general regulatory factor 9; Swiss-Prot: sp|P42654|1433B_VICFA 14-3-3-like protein B; TrEMBL-Plants: tr|I3SI06|I3SI06_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0450800 15
14-3-3 protein-like protein; TAIR: AT2G42590.1 general regulatory factor 9; Swiss-Prot: sp|P42654|1433B_VICFA 14-3-3-like protein B; TrEMBL-Plants: tr|I3SI06|I3SI06_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0450800 15
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|I3S2S9|I3S2S9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0087800 16
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|I3S2S9|I3S2S9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0087800 15
14-3-3 protein; TAIR: AT1G22300.3 general regulatory factor 10; Swiss-Prot: sp|P48347|14310_ARATH 14-3-3-like protein GF14 epsilon; TrEMBL-Plants: tr|A0A0K9RR93|A0A0K9RR93_SPIOL Uncharacterized protein; Found in the gene: LotjaGi4g1v0087800 13
14-3-3 protein, putative; TAIR: AT1G26480.1 general regulatory factor 12; Swiss-Prot: sp|Q9C5W6|14312_ARATH 14-3-3-like protein GF14 iota; TrEMBL-Plants: tr|I3S2S9|I3S2S9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0087800 15
14-3-3 protein; TAIR: AT2G42590.1 general regulatory factor 9; Swiss-Prot: sp|Q96452|1433C_SOYBN 14-3-3-like protein C; TrEMBL-Plants: tr|I3SJQ1|I3SJQ1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0377600 16
14-3-3 protein; TAIR: AT2G42590.1 general regulatory factor 9; Swiss-Prot: sp|Q96452|1433C_SOYBN 14-3-3-like protein C; TrEMBL-Plants: tr|I3SJQ1|I3SJQ1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0377600 15
14-3-3 protein; TAIR: AT2G42590.3 general regulatory factor 9; Swiss-Prot: sp|Q96452|1433C_SOYBN 14-3-3-like protein C; TrEMBL-Plants: tr|I3SJQ1|I3SJQ1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0377600 15
14-3-3 protein; TAIR: AT2G42590.1 general regulatory factor 9; Swiss-Prot: sp|Q96452|1433C_SOYBN 14-3-3-like protein C; TrEMBL-Plants: tr|I3SJQ1|I3SJQ1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0377600 15
14-3-3 protein; TAIR: AT2G42590.2 general regulatory factor 9; Swiss-Prot: sp|Q96452|1433C_SOYBN 14-3-3-like protein C; TrEMBL-Plants: tr|I3SJQ1|I3SJQ1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0377600 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF48445 SUPERFAMILY 1 1.85