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IPR001807

Description

IPR001807 is a Chloride channel.

<p>Chloride channels (CLCs) constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. They are found in organisms ranging from bacteria to yeasts and plants, and also to animals. Their functions in higher animals likely include the regulation of cell volume, control of electrical excitability and trans-epithelial transport [[cite:PUB00000734]]. Some members are plasma membrane Cl channels, while others are Cl/H exchangers [[cite:PUB00155406]].</p> <p>The first member of the family (CLC-0) was expression-cloned from the electric organ of Torpedo marmorata [[cite:PUB00004085]], and subsequently nine CLC-like proteins have been cloned from mammals. They are thought to function as multimers of two or more identical or homologous subunits, and they have varying tissue distributions and functional properties. To date, CLC-0, CLC-1, CLC-2, CLC-4 and CLC-5 have been demonstrated to form functional Cl-channels; whether the remaining isoforms do so is either contested or unproven. One possible explanation for the difficulty in expressing activatable Cl-channels is that some of the isoforms may function as Cl-channels of intracellular compartments, rather than of the plasma membrane. However, they are all thought to have a similar transmembrane (TM) topology, initial hydropathy analysis suggesting 13 hydrophobic stretches long enough to form putative TM domains [[cite:PUB00004085]]. Recently, the postulated TM topology has been revised, and it now seems likely that the CLCs have 10 (or possibly 12) TM domains, with both N-and C-termini residing in the cytoplasm [[cite:PUB00004913]].</p> <p>A number of human disease-causing mutations have been identified in the genes encoding CLCs. Mutations in CLCN1, the gene encoding CLC-1, the major skeletal muscle Cl-channel, lead to both recessively and dominantly-inherited forms of muscle stiffness or myotonia [[cite:PUB00001999]]. Similarly, mutations in CLCN5, which encodes CLC-5, a renal Cl-channel, lead to several forms of inherited kidney stone disease [[cite:PUB00004230]]. These mutations have been demonstrated to reduce or abolish CLC function.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Biological process Chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Cellular component Membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Biological process Transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Associated Lotus transcripts 41

Transcript Name Description Predicted domains Domain count
PREDICTED: chloride channel protein CLC-b-like [Glycine max] gi|356571521|ref|XP_003553925.1| 22
PREDICTED: chloride channel protein CLC-c-like [Cicer arietinum] gi|502126612|ref|XP_004499372.1| 21
Chloride channel protein CLC-d [Medicago truncatula] gi|357480817|ref|XP_003610694.1| 14
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 20
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 16
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 16
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 14
PREDICTED: chloride channel protein CLC-d-like [Glycine max] gi|356497470|ref|XP_003517583.1| 20
PREDICTED: chloride channel protein CLC-d-like [Glycine max] gi|356497470|ref|XP_003517583.1| 19
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 16
PREDICTED: chloride channel protein CLC-f-like isoform X1 [Cicer arietinum] gi|502127375|ref|XP_004499681.1| 16
PREDICTED: chloride channel protein CLC-b-like [Cicer arietinum] gi|502164637|ref|XP_004513192.1| 14
PREDICTED: chloride channel protein CLC-c-like isoform X1 [Cicer arietinum] gi|502162871|ref|XP_004512643.1| 22
PREDICTED: chloride channel protein CLC-e-like [Glycine max] gi|356554044|ref|XP_003545359.1| 13
PREDICTED: chloride channel protein CLC-e-like [Glycine max] gi|356554044|ref|XP_003545359.1| 20
PREDICTED: chloride channel protein CLC-c-like [Cicer arietinum] gi|502126612|ref|XP_004499372.1| 21
Cl-channel clc-7 [Populus trichocarpa] gi|224120342|ref|XP_002331024.1| 21
Chloride channel protein CLC-c [Medicago truncatula] gi|357445225|ref|XP_003592890.1| 22
PREDICTED: chloride channel protein CLC-e [Vitis vinifera] gi|225428374|ref|XP_002280150.1| 10
Chloride channel protein; TAIR: AT4G35440.1 chloride channel E; Swiss-Prot: sp|Q8GX93|CLCE_ARATH Chloride channel protein CLC-e; TrEMBL-Plants: tr|A0A151R5P9|A0A151R5P9_CAJCA Chloride channel protein; Found in the gene: LotjaGi1g1v0000500 20
Chloride channel protein; TAIR: AT3G27170.1 chloride channel B; Swiss-Prot: sp|P92941|CLCA_ARATH Chloride channel protein CLC-a; TrEMBL-Plants: tr|A0A072TXX8|A0A072TXX8_MEDTR Chloride channel protein; Found in the gene: LotjaGi1g1v0623400 21
Chloride channel protein; TAIR: AT3G27170.1 chloride channel B; Swiss-Prot: sp|P92941|CLCA_ARATH Chloride channel protein CLC-a; TrEMBL-Plants: tr|I1N7R2|I1N7R2_SOYBN Chloride channel protein; Found in the gene: LotjaGi1g1v0623400 22
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|G7KPA0|G7KPA0_MEDTR Chloride channel protein; Found in the gene: LotjaGi2g1v0168400 22
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|G7KPA0|G7KPA0_MEDTR Chloride channel protein; Found in the gene: LotjaGi2g1v0168400 20
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|G7KPA0|G7KPA0_MEDTR Chloride channel protein; Found in the gene: LotjaGi2g1v0168400 19
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|G7KPA0|G7KPA0_MEDTR Chloride channel protein; Found in the gene: LotjaGi2g1v0168400 21
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|G7KPA0|G7KPA0_MEDTR Chloride channel protein; Found in the gene: LotjaGi2g1v0168400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|I1JAU5|I1JAU5_SOYBN Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|K7K5J8|K7K5J8_SOYBN Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|A0A067G541|A0A067G541_CITSI Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|I1JAU5|I1JAU5_SOYBN Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|I1JAU5|I1JAU5_SOYBN Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT5G26240.1 chloride channel D; Swiss-Prot: sp|P92943|CLCD_ARATH Chloride channel protein CLC-d; TrEMBL-Plants: tr|I1JAU5|I1JAU5_SOYBN Chloride channel protein; Found in the gene: LotjaGi2g1v0456400 22
Chloride channel protein; TAIR: AT1G55620.1 chloride channel F; Swiss-Prot: sp|Q8RXR2|CLCF_ARATH Chloride channel protein CLC-f; TrEMBL-Plants: tr|A0A1J7IGG9|A0A1J7IGG9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0294500_LC 17
Chloride channel protein; TAIR: AT1G55620.1 chloride channel F; Swiss-Prot: sp|Q8RXR2|CLCF_ARATH Chloride channel protein CLC-f; TrEMBL-Plants: tr|A0A1J7IGG9|A0A1J7IGG9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0294500_LC 17
Chloride channel protein; TAIR: AT1G55620.2 chloride channel F; Swiss-Prot: sp|Q8RXR2|CLCF_ARATH Chloride channel protein CLC-f; TrEMBL-Plants: tr|A0A072UTF6|A0A072UTF6_MEDTR Chloride channel protein; Found in the gene: LotjaGi3g1v0330300 21
Chloride channel protein; TAIR: AT1G55620.2 chloride channel F; Swiss-Prot: sp|Q8RXR2|CLCF_ARATH Chloride channel protein CLC-f; TrEMBL-Plants: tr|A0A072UTF6|A0A072UTF6_MEDTR Chloride channel protein; Found in the gene: LotjaGi3g1v0330300 21
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|A0A072UTT7|A0A072UTT7_MEDTR Chloride channel protein; Found in the gene: LotjaGi4g1v0001100 21
Chloride channel protein; TAIR: AT5G33280.1 Voltage-gated chloride channel family protein; Swiss-Prot: sp|P60300|CLCG_ARATH Putative chloride channel-like protein CLC-g; TrEMBL-Plants: tr|G7JFF4|G7JFF4_MEDTR Chloride channel protein; Found in the gene: LotjaGi4g1v0277500 20
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|Q1SKZ4|Q1SKZ4_MEDTR Chloride channel protein; Found in the gene: LotjaGi6g1v0328900 22
Chloride channel protein; TAIR: AT5G49890.1 chloride channel C; Swiss-Prot: sp|Q96282|CLCC_ARATH Chloride channel protein CLC-c; TrEMBL-Plants: tr|Q1SKZ4|Q1SKZ4_MEDTR Chloride channel protein; Found in the gene: LotjaGi6g1v0328900 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd04591 CDD 1 2.44