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IPR020045 is a DNA polymerase I-like, H3TH domain.
<p>This entry represents the H3TH (helix-3-turn-helix) domain of the 5'-3' exonuclease (53EXO) of mutli-domain DNA polymerase I and single domain protein homologues. Taq (Thermus aquaticus) DNA polymerase I contains a polymerase domain for synthesizing a new DNA strand and a 53EXO domain for cleaving RNA primers or damaged DNA strands [[cite:PUB00086543], [cite:PUB00019069]]. Taq's 53EXO recognizes and endonucleolytically cleaves a structure-specific DNA substrate that has a bifurcated downstream duplex and an upstream template-primer duplex that overlaps the downstream duplex by 1 bp [[cite:PUB00086542]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: DNA repair protein UVH3-like [Glycine max] gi|356498232|ref|XP_003517957.1| | 20 | ||
| – | PREDICTED: 5'-3' exonuclease-like [Glycine max] gi|356561357|ref|XP_003548949.1| | 6 | ||
| – | Flap endonuclease GEN-like protein [Medicago truncatula] gi|357507117|ref|XP_003623847.1| | 17 | ||
| – | PREDICTED: flap endonuclease GEN-like 2-like [Cicer arietinum] gi|502175270|ref|XP_004515700.1| | 21 | ||
| – | PREDICTED: DNA polymerase I-like isoform X2 [Cicer arietinum] gi|502142965|ref|XP_004505167.1| | 8 | ||
| – | PREDICTED: DNA polymerase I-like isoform X2 [Cicer arietinum] gi|502142965|ref|XP_004505167.1| | 11 | ||
| – | PREDICTED: exonuclease 1-like [Cicer arietinum] gi|502140539|ref|XP_004504251.1| | 24 | ||
| – | PREDICTED: flap endonuclease 1-like isoform X3 [Cicer arietinum] gi|502117445|ref|XP_004495823.1| | 23 | ||
| – | 5'-3' exonuclease; TAIR: AT1G34380.2 5'-3' exonuclease family protein; Swiss-Prot: sp|O67550|EX53_AQUAE 5'-3' exonuclease; TrEMBL-Plants: tr|K7MHK5|K7MHK5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0098200 | 16 | ||
| – | Flap endonuclease Xni; TAIR: AT3G52050.1 5'-3' exonuclease family protein; Swiss-Prot: sp|O52225|DPO1_THEFI DNA polymerase I, thermostable; TrEMBL-Plants: tr|A0A0S3R340|A0A0S3R340_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0069300 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09898 | CDD | 1 | 10.00 |