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IPR008918 is a Helix-hairpin-helix motif, class 2.
<p>The helix-hairpin-helix (HhH) motif is an around 20 amino acids domain present in prokaryotic and eukaryotic non-sequence-specific DNA binding proteins. The HhH motif is similar to, but distinct from, the helix-turn-helix (HtH) and the helix-loop-helix (HLH) motifs. All three motifs have two helices (H1 and H2) connected by a short turn. DNA-binding proteins with a HhH structural motif are involved in non-sequence-specific DNA binding that occurs via the formation of hydrogen bonds between protein backbone nitrogens and DNA phosphate groups. These HhH motifs are observed in DNA repair enzymes and in DNA polymerases. By contrast, proteins with a HtH motif bind DNA in a sequence-specific manner through the binding of H2 with the major groove; these proteins are primarily gene regulatory proteins. DNA-binding proteins with the HLH structural motif are transcriptional regulatory proteins and are principally related to a wide array of developmental processes [[cite:PUB00015243]].</p> <p>Examples of proteins that contain a HhH motif include the eukaryotic/prokaryotic RAD2 family of 5'-3' exonucleases such as T4 RNase H and T5 [[cite:PUB00011713], [cite:PUB00011714]], eukaryotic 5' endonucleases such as FEN-1 (Flap) [[cite:PUB00011712]], and some viral exonucleases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: DNA repair protein UVH3-like [Glycine max] gi|356498232|ref|XP_003517957.1| | 20 | ||
| – | PREDICTED: DNA polymerase I-like isoform X2 [Cicer arietinum] gi|502142965|ref|XP_004505167.1| | 11 | ||
| – | PREDICTED: exonuclease 1-like [Cicer arietinum] gi|502140539|ref|XP_004504251.1| | 24 | ||
| – | PREDICTED: flap endonuclease 1-like isoform X3 [Cicer arietinum] gi|502117445|ref|XP_004495823.1| | 23 | ||
| – | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 20 | ||
| – | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 26 | ||
| – | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 24 | ||
| – | Flap endonuclease Xni; TAIR: AT3G52050.1 5'-3' exonuclease family protein; Swiss-Prot: sp|O52225|DPO1_THEFI DNA polymerase I, thermostable; TrEMBL-Plants: tr|A0A0S3R340|A0A0S3R340_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0069300 | 19 | ||
| – | Flap endonuclease 1; TAIR: AT1G29630.2 5'-3' exonuclease family protein; Swiss-Prot: sp|Q60GC1|EXO1_ORYSJ Exonuclease 1; TrEMBL-Plants: tr|K7L667|K7L667_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0382400 | 25 | ||
| – | Flap endonuclease 1; TAIR: AT5G26680.2 5'-3' exonuclease family protein; Swiss-Prot: sp|C6TEX6|FEN1_SOYBN Flap endonuclease 1; TrEMBL-Plants: tr|I3SAA1|I3SAA1_LOTJA Flap endonuclease 1; Found in the gene: LotjaGi5g1v0234800 | 27 | ||
| – | Flap endonuclease 1; TAIR: AT5G26680.3 5'-3' exonuclease family protein; Swiss-Prot: sp|C6TEX6|FEN1_SOYBN Flap endonuclease 1; TrEMBL-Plants: tr|A0A072VM97|A0A072VM97_MEDTR Flap endonuclease 1; Found in the gene: LotjaGi5g1v0234800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09907 | CDD | 1 | 9.09 |